Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Shevin  Jacob Thomas
ID:
AN OBSERVATIONAL STUDY TO ASSESS THE UTILITY OF BEDSIDE ULTRASOUND SCAN IN SEPSIS TREATMENT AMONG HOSPITALIZED ADULTS IN UGANDA
REFNo: HS1499ES

General objective: To describe the potential utility of bedside ultrasound scanning in evaluating adult patients with suspected sepsis admitted to hospitals in Uganda Specific objectives: 1. Estimate the proportion of patients admitted to the medical emergency unit with suspected sepsis who have ultrasound findings consistent with intravascular fluid depletion. 2. Estimate the proportion of patients admitted to the medical emergency unit with suspected sepsis who have ultrasound findings suggestive of intolerance to high volume intravenous fluid. 3. Estimate the proportion of patients admitted to the medical emergency unit with suspected sepsis who have ultrasound findings that identify a potential source of infection. 4. Determine the feasibility of delivering POCUS to evaluate non-pregnant adult patients with sepsis by clinicians who are not specialized in radiology.
USA 2021-07-16 2024-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 Determination of Adequate TUberculosis Regimen in Adults and adolescents hospitalised with HIV-associated severe immune suppression (Acronym: DATURA).
REFNo: HS1487ES

Primary objective: To estimate the impact of an intensified initial phase of tuberculosis (TB) treatment on mortality at 48 weeks among HIV-infected adults and adolescents hospitalised for TB with CD4 ≤ 100 cells/μL in comparison with the standard TB regimen. Secondary objectives: To estimate the impact of an intensified initial phase of TB treatment, in comparison with the standard TB regimen, on: ¥ Mortality at weeks 8 and 24 ¥ Adverse events, including: - All grade 3-4 events - Selected grade 2 events of interest - Drug-related adverse events - AIDS defining illnesses - Paradoxical TB-associated immune reconstitution inflammatory syndrome (IRIS) ¥ TB treatment success ¥ TB recurrence ¥ Antiretroviral treatment (ART) response in terms of virological success and immunological response ¥ Adherence to TB treatment and ART ¥ Peak plasma concentrations of rifampicin and isoniazid (and its N-acetyl-metabolite) at day 3, day 7 and week. ¥ Plasma concentrations of efavirenz and dolutegravir at week 4 (i.e. 2 weeks after the onset of ART)
Uganda 2021-07-16 2024-07-16 Medical and Health Sciences Clinical Trial Non-degree Award
Davis Ntulume Roland
ID:
A Cross Sectional Study on Exploring the Lifestyle of Makerere University Staff With an Aim of developing a Bespoke Healthy Living Program for people in Academia
REFNo: HS1500ES

Our main goal is to identify and understand the key factors that attribute a typical working day of Makerere University and inhibitors of following a heathy living programme and use this feedback
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to design a contextually appropriate and bespoke programme for adoption in the field of academia and other sectors at large. This will be achieved in the following sub aims:
1. To establish the dietary and physical activity patterns of overweight and obese staff at Makerere University College of Health Sciences staff.
2. To support overweight and obese individuals to adopt an energy restricted diet and weekly physical exercise while establishing the behavioural and social determinants of compliance to the programme.
3. To establish the effect of change on food and activity body weight and health status and recommend a bespoke healthy living programme that puts into consideration the routine, perceptions and inhibitors to living a healthy lifestyle that works for Academic staff nationwide.
 Uganda 2021-07-16 2024-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jude Ssempebwa
ID:
COVID-19 and the Youth Question in Africa: Piloting a Vertically Integrated Social Accountability and Advocacy Framework in the IGAD Region (COYOQA)
REFNo: SS921ES

1. To carry out a comprehensive gender analysis of the current social mobilization of youth in informing, co-designing and supporting COVID-19 pandemic emergency preparedness and response, capacity, key gaps and support needs among IGAD Member States (Ethiopia, Kenya and Uganda).
2. To build the capacity of male and female Youth Volunteers for Behavior Change (YOV4BC) in emergency preparedness, response (disaster risk reduction and management) and building resilience to impacts of COVID-19 so that they are well informed, resourced and educated about COVID-19 and its prevention measures.
3. To partner with the youth to take action within their communities through developing and institutionalizing a standardized and harmonized COVID-19 Vertically Integrated Social Accountability and Advocacy Framework for monitoring the IGAD Regional Response Strategy(IRRS) for COVID-19 Pandemic in Kenya, Uganda and Ethiopia.
4. To investigate and track gender differentiated sectoral socio-economic impacts of COVID-19 on youth and their communities and document community perceptions and response strategies.
5. To facilitate meaningful policy engagement between male and female youth and policy makers through enhanced national, sub-national and regional knowledge sharing platforms.

 Uganda 2021-07-16 2024-07-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Roselline Achola
ID:
Decision making about Family Planning use by refugee and host populations in Adjumani district, Uganda
REFNo: SS809ES

1.To explore decision making processes for FP use by refugee and host population in Adjumani district
2.To establish factors associated with FP use by women and men in the refugee and host populations in Adjumani
3.To develop and evaluate an intervention to increase FP use by refugee and host populations

Uganda 2021-07-15 2024-07-15 Social Science and Humanities Non-Clinical Trial Degree Award
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