Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Benon Asiimwe Byamugisha
ID:
COVID-19 and Antimicrobial Resistance in East Africa: impact and response (CARE)
REFNo: HS1519ES

To establish how community members have received and responded to health messages on COVID-19,To examine how the COVID-19 crisis is affecting patient treatment seeking, drug use, and understanding of illness, and how this is affecting the wider landscape of AMR,To the establish antibiotic provision landscape from the perspective of drug sellers, pharmacists, traditional medicine providers, and formal healthcare workers,To investigate how COVID-19 may be modifying patients’ treatment seeking behaviour, their usage of medicines/ABs and affecting access to and provision of ABs in the therapy landscape in Uganda,
Uganda 2021-07-22 2024-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mauro Giacomazzi
ID:
Effectiveness of the Whole School System Approach in Fostering Critical Thinking among Learners in Ugandan Secondary Schools
REFNo: SS931ES

Main objective To investigate how the whole school system approach to critical thinking contributes to the development of leaners’ cognitive abilities in Ugandan secondary schools. Specific objectives (i) To establish the meaning of critical thinking in the Ugandan context. (ii) To explore how teachers can improve their teaching and learning through the critical thinking activation approach. (iii) To explore how critical thinking can be appropriately assessed in the Ugandan secondary school context. (iv) To establish the extent to which the whole school system approach contributes to the development of critical thinking abilities of Ugandan secondary school learners. (v) To establish individual, school and home related factors that influence critical thinking abilities of Ugandan secondary school learners. (vi) To explore the strategies that Ugandan secondary school teachers use in preparing and delivering critical thinking augmented lessons.
Italy 2021-07-22 2024-07-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
The role of prolonged exposure to parasitemia in the high morbidity in children with Sickle cell anaemia in Uganda
REFNo: HS1496ES

Primary Aims
1. To determine the rate of parasite clearance during artesunate therapy in children with sickle cell anaemia compared to children without SCA.
We hypothesize that children with SCA will experience parasite clearance half-life times exceeding the WHO-defined standard of 5 hours when treated with artemisinins for P. falciparum malaria, whereas children without SCA will not experience this delayed parasite clearance.

2. To determine the association between parasite clearance rate and risk of vaso-occlusive crisis, severe anaemia, and any hospitalisation in children with SCA.
We hypothesize that prolonged parasite clearance will correlate with increased risk of SCA-related sequelae.

3. To determine the association between kidney and splenic function and parasite clearance half-life during artesunate treatment for malaria.
We hypothesize that impaired renal function (estimated creatinine clearance) and splenic function (presence of Howell-Jolly bodies) will correlate with increased parasite clearance half-life.

Secondary Aims
1. To determine the incidence of treatment failure (new clinical malaria within a 28-day follow-up period after microscopy-confirmed parasite clearance) after artemisinin combination therapy for malaria
2. To detect and measure the prevalence of parasite genetic markers of artemisinin resistance in Jinja

Uganda 2021-07-21 2024-07-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
James Nyonyintono Mwangwa
ID: UNCST-2023-R005636
Feasibility of Use of the PATH bCPAP Kit including Oxygen Blenders in a Neonatal Population in Uganda
REFNo: HS650ES

Primary Objectives: 1. To assess the operational feasibility of using the PATH bCPAP kit including, when appropriate, in-line oxygen blending on neonatal patients. 2. To assess the usability and acceptability of the PATH bCPAP kit with oxygen blenders by healthcare workers. Secondary Objective: 1. To report clinical characteristics, demographics and outcomes of patients treated with the PATH bCPAP kit and blenders in a newborn care unit in rural Uganda.
Uganda 2021-07-19 2024-07-19 Medical and Health Sciences Non-degree Award
Esther Buregyeya
ID: UNCST-2020-R014116
Using a behavioural approach to design an antimicrobial stewardship intervention in healthcare facilities in Kampala, Mukono and Luwero Districts, Uganda
REFNo: HS1303ES

1. To explore the barriers to and facilitators for rational use of antibiotics and setting up AMS programs in HCFs in Uganda.
2. To develop, pilot an AMS behavioural intervention and assess its acceptability, feasibility and effect to foster appropriate antibiotic prescription in HCFs in Uganda.
3. To assess the cost of the intervention in fostering rational use of antibiotics in Uganda.

Uganda 2021-07-16 2024-07-16 Medical and Health Sciences Non-degree Award
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