Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Andrew Katumba
ID:
A Machine Learning-aided Platform for Point-of-Care Pregnancy Risk Assessment from 2D Ultrasound
REFNo: HS4144ES

1. To develop a predictive ML model based on ultrasound, clinical, and demographic data to categorize pregnancy risk and enable the community health worker to make appropriate and timely intervention recommendations.
2. To integrate the ML model in the image processing pipeline of a hand-held portable ultrasound system.
3. To pilot and evaluate the efficacy of the predictive and diagnostic models in managing high-risk pregnancies.

 Uganda 2024-06-21 17:54:02 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Martin Bikorwomuhangi
ID:
INCIDENCE, INDICATIONS AND SHORT-TERM OUTCOMES OF NON-CONVENTIONAL INTRA-ABDOMINAL DRAINS AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: SS2689ES

4.To determine the association between different types of non-conventional intra-abdominal drains and short-term outcomes among patients who undergo intra-abdominal surgery at Surgical ward MRRH,3.To describe the different short-term outcomes among patients with non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,2.To document the various indications of non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,1.To determine the incidence of non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,To determine the incidence, indications and short-term outcomes of non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,
 Uganda 2024-06-21 17:53:08 2027-06-21 Social Science and Humanities Non-Clinical Trial Degree Award
Stevens Bechange
ID: UNCST-2022-R009190
 Eye Health Systems Assessment – Uganda
REFNo: HS4368ES

Examine how the above components of the eye health system recognise and address the needs of groups identified as vulnerable to exclusion from services,Assess the available eye care infrastructure,Assess the information system for eye health,Determine available medical products, vaccines and technologies for eye care,Determine available human resources for eye health,Describe eye care service delivery ,Assess the health financing mechanisms in operation,Describe the governance and leadership function ,The overall objective of this study is to examine and document the strengths and weaknesses of all components of the eye health care delivery system and health system linkages – thus providing a basis for targeted programmatic work to strengthen the eye health systems infrastructure and improving outcomes for eye conditions in Uganda.,
 Uganda 2024-06-21 17:51:54 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
George Kasule William
ID: UNCST-2023-R006891
 EVALUATION OF NON-SPUTUM-BASED DIAGNOSTICS AND BIOMARKERS FOR DETECTION OF M. TUBERCULOSIS AMONG CHILDREN AND PEOPLE LIVING WITH HIV
REFNo: HS4344ES

To assess literature review of Mycobacterium tuberculosis biomarkers in non-invasively collected non-sputum samples of the Oral-Gut and Nasal pharynx parts of humans. To determine the diagnostic performance of novel stool-based biomarkers for detecting tuberculosis in children and among PLHIV using stool samples.To determine the diagnostic performance of breath-based biomarkers for detecting tuberculosis in children and among PLHIV.To determine the diagnostic performance of novel urine-based biomarkers for detecting tuberculosis in children and among PLHIV.To explore health workers’ and policymakers’ perceptions on the use of non-sputum-based assays for detecting tuberculosis in children and among PLHIV in Uganda.
 Uganda 2024-06-21 17:50:21 2027-06-21 Medical and Health Sciences Non-Clinical Trial Degree Award
Rose Nabirye Chalo
ID: UNCST-2020-R014645
 DEVELOPMENT OF AN INTER-PROFESSIONAL EDUCATIONAL PROGRAMME FOR THE ASSESSMENT OF MENTAL HEALTH OF PREGNANT TEENAGERS
REFNo: SS2691ES

The proposed project seeks to promote inter-professional education by developing an educational programme that will be used for inter-professional training of students in the health professions on the mental health assessment of pregnant teenagers.,
 Uganda 2024-06-21 17:48:53 2027-06-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Daniel Iraguha Ndungutse
ID: UNCST-2024-R003686
 DETECTION OF PAROXYSMAL ATRIAL FIBRILLATION AMONG RHEUMATIC HEART DISEASE REGISTRY PATIENTS AT THE UGANDA HEART INSTITUTE, A PREVENTIVE STRATEGY AGAINST STROKE
REFNo: HS4389ES

• To determine the prevalence of paroxysmal
atrial fibrillation using ambulatory ECG
monitoring among participants with severe
RHD in the Uganda Heart registry
• To determine factors associated with
paroxysmal atrial fibrillation among
participants with severe RHD in the Uganda
RHD registry

 Uganda 2024-06-21 17:47:52 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Izudi
ID: UNCST-2019-R000469
 Integrating Tuberculosis Treatment into Community Pharmacies to improve TB/HIV outcomes in Uganda: the Community Pharmacy Tuberculosis Treatment (COPHAT) study
REFNo: HS4397ES

To evaluate the implementation and preliminary effectiveness of integrating TB treatment into community pharmacies among people with TB/HIV.,To adapt a person-centered strategy for integrating TB treatment into community pharmacies using a human-centered design methodology.,To explore the barriers and facilitators to integrating TB treatment into community pharmacies among people with TB/HIV.,The main objective of this Community Pharmacy Tuberculosis Treatment (COPHAT) study is to develop and pilot an implementation strategy focused on integrating TB treatment into community pharmacies among people with TB/HIV in Kampala, Uganda. ,
 Uganda 2024-06-21 17:46:35 2027-06-21 Medical and Health Sciences Clinical Trial Non-degree Award
JUSTINE MUKALERE
ID:
CONNECTING COMMUNITIES TO HEALTH SYSTEMS THROUGH VILLAGE HEALTH TEAMS: A TECHNOLOGY-ENABLED FRAMEWORK. A CASE OF BUGWERI, BULAMBULI, KIBUKU DISTRICTS
REFNo: SIR284ES

iii. To evaluate the designed framework to establish its applicability in connecting communities to health systems.,ii. To design a technology-enabled framework that will connect villages to health systems through Village Health Teams,i. To study the challenges faced by Village Health Teams in Kibuku, Bulambuli and Bugweri districts based on the existing framework and generate requirements,To enhance the connectivity between communities and the health systems through Village Health Teams based on a technology-enabled framework.,
 Uganda 2024-06-21 17:45:14 2027-06-21 Engineering and Technology Non-Clinical Trial Degree Award
Leticia Kyohangirwe
ID: UNCST-2024-R004144
 Determining the effect of psychiatric disorders on clinical outcomes among adolescents with HIV in Uganda over a one-year period.
REFNo: HS4120ES

The overall objective is to determine effect of psychiatric disorders on clinical outcomes among adolescents with HIV in Uganda using a longitudinal analysis approach.
 Uganda 2024-06-19 15:57:59 2027-06-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kearsley Stewart
ID: UNCST-2021-R011830
 Addressing Sickle Cell Disease in Uganda: A Multi-Sectoral Approach
REFNo: HS4276ES

Aim 3: We aim to assess the current digital capacity (smart mobile phone access, internet access, data security, access to data) of KHCIV sickle cell patients, their caregivers, and KHCIV clinic staff in order to understand their preparedness for using mobile applications to improve sickle cell disease care. We seek to identify facilitators and barriers to uptake of mHealth tools and interventions, including Nanbar Health for patients and SCD Toolbox for KHCIV providers. In addition, we aim to determine the feasibility of using the Nanbar Health and SCD Toolbox mobile applications in Kalangala District and propose solutions for adaptation to enhance sickle cell care and improve outcomes beyond Kalangala District for others in Uganda. ,Aim 2: We aim to improve clinical monitoring of home-based adherence to hydroxyurea by exploring the feasibility and acceptability of using a rapid point-of-care electrophoresis sickle cell test (Gazelle) to monitor fetal hemoglobin for sickle cell patients taking hydroxyurea at their quarterly clinic visits to KHCIV. In addition, we aim to understand the facilitators and barriers to successful home-based adherence to hydroxyurea through a home visit to interview patient and caregivers about their adherence-related behaviors and observe conditions in the home that directly influence adherence to hydroxyurea, such as pill storage. ,Aim 1: We aim to explore the facilitators and barriers to uptake of newborn screening at KHCIV at a time when the Government of Uganda is scaling up newborn sickle cell testing across the country. We will describe the challenges for staff at a remote government health care facility to scale up newborn sickle cell testing. We will study parental perspectives on newborn sickle cell testing and their experiences with the current standard-of-care (dried blood spots) sent by KHCIV to the Central Public Health Laboratory in Kampala.,This study aims to reduce the burden of SCD in Uganda through a multi-sectoral study of the facilitators and barriers to: scale-up of universal newborn screening, adherence to treatments such as hydroxyurea, and improved access to sickle cell health education through mHealth digital apps. ,
 USA 2024-06-18 11:20:00 2027-06-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
 The Rakai Orphans in Communities (ROC)
REFNo: SS2744ES

The specific aims are to:
1. Define, over time, the potentially changing impact of orphanhood on HIV risk factors and HIV infection among AYA from RCCS Rounds 6-23 (1999-2027).
2. Explore issues related to mechanism and measurement to better understand the population burden of orphanhood among AYA. Key issues include 1-timing of orphaning (i.e., age they became an orphan), 2-influence of orphanhood vs. parental absence from the household, 3-the burden of orphanhood over time among children 0-14 years, and 4-validating the route of transmission (behavioral vs. perinatal) among adolescents first entering the RCCS.
3. Through life history interviews, explore the mechanisms by which orphanhood and age at orphaning may influence HIV risk among AYA and adolescent social outcomes and to assess how programs can be tailored to meet the needs of this vulnerable population. Interviews will be conducted with youth and their adult caretakers; each should be able to differentially report on events and circumstances of the orphaning period.
4. Estimate the economic impact of declining HIV-related orphanhood on youth, families, and communities. In a cost-benefit analysis, we will examine benefits of declining orphanhood (decreased adult mortality, decreased orphanhood, increased educational status, decreased HIV infection among youth) and costs (costs for ART, MMC).
Uganda 2024-06-17 11:41:08 2027-06-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
John Ekure
ID:
LONG-TERM OUTCOMES OF THE MANAGEMENT OF OPEN FRACTURES AT KUMI ORTHOPAEDIC CENTER: A RETROSPECTIVE AND PROSPECTIVE LONGITUDINAL STUDY
REFNo: HS3238ES

To prospectively determine the long-term outcomes of management of open fractures of long bones at KOC from Sept 2023 to Sept 2033.,To retrospectively determine the long-term outcomes of the management of open fractures of long bones at Kumi Orthopaedic Center from 2010 to 2022.,to retrospectively and prospectively determine the long-term outcomes of the management of open fractures of long bones using surgical techniques at Kumi Orthopaedic Center.,
 Uganda 2024-06-12 15:43:48 2027-06-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Philip  Tibenderana
ID:
Spatiotemporal assessment of roof-harvested rainwater quality in Kigezi Highlands
REFNo: SIR259ES

iii) Establish a correlation matrix between retention time and water quality,ii) Determine the level of purity of roof-harvested rainwater from different rooftops and tank materials as compared with the WHO and Uganda drinking water standards;,i) Evaluate the physical, chemical and bacteriological water quality of the samples of harvested and stored rainwater,The overall objective ofTo investigate the spatiotemporal variability in quality of roof-harvested rainwater in Kigezi Highlands, Uganda.,
 Uganda 2024-06-12 15:41:10 2027-06-12 Engineering and Technology Non-Clinical Trial Non-degree Award
Aaron Sandel
ID:
Deep bonding: A new science of affect in wild primates
REFNo: NS805ES

Initiate a new paradigm for studying relationships in wild primates through the scientific study of “emotions” or affective states. Study three key species for investigating social bonds: chimpanzees and baboons in Kibale National Park and gorillas in Bwindi Impenetrable National Park. We will combine behaviour, hormones, and psychophysiology methods. This builds on my long-term study of chimpanzees at Ngogo (The development of social bonds in male chimpanzees).
 USA 2024-06-12 15:39:23 2027-06-12 Natural Sciences Non-Clinical Trial Non-degree Award
George Mukose
ID:
Public-Private Partneships Stopgap and the Performance of Universasl Secondary Educstion in Uganda
REFNo: SS2217ES

To evaluate the performance of Universal Seconadry Education under Public-Private Partnerships Stopgap,Explore the perceptions of stakeholders about the Perfomance of Universal Secondary Education under the Public-Private Partnerships stopgap,Assess the relevamce of the Public-Private Partnerships stopgap under Universal Secondary Education in Kamuli District,Evaluate how the Public-Private Partnerships stopgapaffected equity under the Universal Secondary Education in Kamuli District,Analyse the influence of the Public-Private Partnerships stopgap on the quality of Universal Secondary Education in Kamuli District,Examine the extent to which the Public-Private Partnerships stopgap affected access to Universal Secondary Education,
 Uganda 2024-06-12 15:38:30 2027-06-12 Social Science and Humanities Non-Clinical Trial Degree Award
Catherine Carlson
ID: UNCST-2023-R007222
 Sharing HaRT in New Expanses (SHINE)
REFNo: SS2002ES

Understand potential barriers and facilitators to future implementation and scale-up.,Explore participant characteristics (e.g., age, trafficking history, food security) that may moderate the intervention effectiveness.,Determine effectiveness of the Move with HaRT intervention on PTSD, depression, and anxiety symptoms among survivors of human trafficking in Uganda,To evaluate the mental health impact of Move with HaRT with human trafficking survivors in Uganda.,
 USA 2024-06-12 15:35:44 2027-06-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Alison Elliott
ID: UNCST-2023-R006524
 VAnguard community survey: exploring interrelationships between structural, social, and biological determinants of vaccine impact in Kenya and Uganda
REFNo: SS2309ES

Goal To investigate structural, social and biological determinants that hinder vaccine impact in vulnerable communities in Uganda and Kenya. Specific objectives 1. To explore structural and social determinants that hinder vaccine impact in vulnerable communities. 2. To assess the effect of biological determinants on the proxy markers of vaccine impact in vulnerable communities 3. To explore the interrelationships between structural, social and biological determinants and their combined influence on proxy markers of vaccine impact in vulnerable communities
UK 2024-06-12 15:33:11 2027-06-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Job Morukileng
ID:
Analysis of the causes and trends of deaths in Kampala City Authority Mortuary: A 5-year retrospective study 2019-2023
REFNo: HS4358ES

2. To describe the causes of deaths in Kampala city mortuary from January 2019 to December 2023.,To describe the trends of deaths in KCCA mortuary from January 2019 to December 2023,To describe the trends and causes of deaths in Kampala Capital City Authority mortuary from 2019-2023,
 Uganda 2024-06-12 15:28:21 2027-06-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
John Kamulegeya
ID: UNCST-2024-R004775
 Understanding School Health Service Provision in Uganda RefNo:IDI-REC-2024-94:
REFNo: HS4331ES

To generate evidence-based recommendations for strengthening the school health service activities, vaccination screening and HPV vaccination delivery in Uganda,To identify facilitators and barriers to HPV vaccination uptake in school-based settings amongst school administrators/teachers, healthcare workers and parents/caregivers, including key behavioral, system and social drivers and barriers.,To identify rationale for, facilitators and barriers to school-based vaccination checks and implementation of catch-up vaccination following these checks,To describe the implementation of school-based vaccination checks among a sample of primary and secondary schools in Uganda.,To generate evidence on facilitators and barriers to planning, implementation and monitoring of school health service activities.,To identify and describe best practices for cross-sectoral collaboration,To document roles of key stakeholders in school-based preventative health activities, including Community Service Organizations ,To understand the current delivery of recommended preventative school health service activities in Uganda, including provision of vaccination, health screening and health education,To understand the extent of implementation, facilitators and barriers to the current school health services in Uganda in order to generate evidence-based recommendations to inform implementation of priority activities, especially school-based vaccination checks and HPV vaccination delivery. ,
 Uganda 2024-06-12 14:28:43 2027-06-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Marion Mugisha Mutabazi
ID:
RESEARCH & LEARNING PARTNERSHIP FOR EARLY CHILDHOOD DEVELOPMENT (ECD) AND LIVELIHOODS PROJECT IN URBAN KAMPALA AND REFUGEE SETTLEMENTS IN UGANDA
REFNo: SS2623ES

1. To assess facilitators and barriers to implementation of proposed interventions and document successes and learnings. 2. To document formal and informal child care practices for children below 3 years adopted by refugee youth involved in the livelihood skilling program. 3. To measure effectiveness of program interventions (childcare, ECD and youth livelihood training) in addressing the needs of refugee youths. 4. To assess the fit of intervention delivery approach to realizing the proposed outcomes for refugee youth and their children.,
 Uganda 2024-06-12 14:25:17 2027-06-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
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