Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
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Stakeholder perceptions and ethical considerations in gene therapy clinical trials for sickle cell disease in Uganda
REFNo: SS3570ES
Aim 1: To determine stakeholder perceptions of somatic gene therapy for SCD. We shall engage patient support and advocacy groups to ascertain knowledge gaps, expectations, and preferences regarding gene therapy. This will facilitate patient education and smooth implementation of research and development of affordable and accessible gene therapy in LMICs.
Aim 2: To examine the ethical, legal, and social considerations in somatic gene therapy clinical trials for SCD in a resource-limited setting. We shall use deliberative focus group discussions and key informant interviews to explore the ethical and social considerations in somatic gene therapy research in low-resource settings.
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Uganda |
2025-04-09 16:28:31 |
2028-04-09 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
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Is Healthcare a Common Good? Philosophical Perspectives and Clinical
Practices in Boston and Kampala
REFNo: SS4184ES
1. To develop a philosophical framework for conceptualizing healthcare as a
common good by drawing on African and North Atlantic philosophical traditions.
2. Explore clinicians’ conceptions of health, the common good, and professional
practice.
3. To analyze how differing conceptions of healthcare affect experiences of burnout and moral injury.
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Uganda |
2025-09-23 10:58:51 |
2028-09-23 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Allan Ochieng
ID:
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Understanding the need for inoculation of common in Uganda
REFNo: A12ES
Objective 1: Determine the abundance and diversity of indigenous rhizobia nodulating common bean in Uganda and the factors influencing them. This will be achieved by establishing if uninoculated soil from different Agroecological zones (AEZ) differ in the ability to support effective nitrogen fixation and if this difference is related to the abundance and composition of the native rhizobial population.\r\n\r\nSpecific objective 1.1: Estimate the population density of indigenous rhizobia in different soils and determine the effect of the soil properties on the rhizobial population.\r\n\r\nSpecific objective 1.2: Determine the rhizobial composition in different soils and factors that influence it.\r\n\r\nSpecific objective 1.3: Determine the effectiveness of nitrogen fixation of rhizobial populations derived from different soils and factors that influence it.\r\n\r\nObjective 2: Determine the competitiveness of indigenous rhizobial populations from different soils with respect to current strains used for bean inoculation.\r\n\r\nSpecific objective 3: Test effectiveness, adaptability and competitiveness of the identified superior indigenous rhizobia under greenhouse conditions.\r\n\r\nSpecific objective 4: Test effectiveness, adaptability and competitiveness
|
Uganda |
2017-01-17 |
2020-01-17 |
Agricultural Sciences |
|
Degree Award |
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Carissa Western Strum
ID:
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Emergent Empowerment: Assessing the Impacts of Conflict on Gendered Relations, Identities and Opportunities in Acholiland
REFNo: SS58ES
The research project will seek to explore changes in gender roles and dynamics brought about by conflict in Acholiland, Northern Uganda, and to understand how these changes have affected cultural/traditional ideas about masculinity and femininity and the positions/situation of Acholi women and men in post-conflict society. While research has indicated both local level economic gains, and changes in women’s political participation and representation at the national level, this research will seek to explore, holistically, how changes brought about by conflict impact, both positively and negatively, all aspects of Acholi women (and men’s) lives. The project will therefore prioritize Acholi women and men’s own interpretation of their conflict experiences, and of the impact of conflict-triggered changes on their roles and status within their families and communities. Given the significant role played by NGOs/INGOs in implementing Northern Uganda’s peacebuilding and development agenda, the project will also seek to understand how organizations/stakeholders working in this context are addressing and responding to changing gender norms and dynamics, and whether such approaches are in line with women and men’s own interpretation of their experiences and needs.
|
Kenya |
2017-07-13 |
2020-07-13 |
Social Science and Humanities |
|
Degree Award |
|
China Scherz Rose
ID:
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Investigating the Role of Spiritual Experience and Social Support in Processes of Personal Change: Alcohol Abuse and Therapeutic Pathways in Uganda
REFNo: SS65ES
RESEARCH QUESTION TO BE ADDRESSED BY THIS PROPOSAL
1) How do spiritual experiences influence people’s efforts to change health-related behaviors?
2) How does social support influence people’s efforts to change their health-related behaviors?
3) How are these two factors interrelated?
|
USA |
2017-06-13 |
2020-06-13 |
Social Science and Humanities |
|
Non-degree Award |
|
Anne Odele
ID:
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The meaning, uses and outcomes of functional adult literacy in Uganda
REFNo: SS52ES
The study seeks to describe: \r\n(1) how former literacy participants use the learning from the FAL program in the domains of a) reading, writing and numeracy; and b) their daily livelihoods, and why\r\n(2) the perceived outcomes of applying these practices\r\n(3) the meanings that literacy holds for the participants\r\n
|
Uganda |
2017-06-27 |
2020-06-27 |
Social Science and Humanities |
|
Degree Award |
|
Karolina Werner
ID:
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From Statebuilding to Localized Governance: Exploring African governance structures
REFNo: SS56ES
The project focuses on understanding the legal integration of informal/traditional authorities into the governance of states in sub-Saharan Africa. The objective is to better understand the unique systems of governance present on the continent, providing a comparative study of four countries (Uganda, Zambia, Mozambique, Botswana) with varying degrees of integration.
|
Canada |
2018-02-13 |
2021-02-13 |
Social Science and Humanities |
|
Degree Award |
|
Laura Bogart
ID:
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Game Changers: A Pilot Intervention to Empower HIV Clients as Prevention Advocates in Uganda
REFNo: HS32ES
1) Use qualitative focus group research to assess the feasibility and acceptability of implementing an HIV prevention advocacy intervention with PLHA in HIV care, who will be trained to be advocates of HIV protective behaviours within their social networks.\r\n2) Develop an intervention based on the focus group data and community advisory board and IDI staff input. \r\n\r\nNote: the pilot intervention will be tested in a small randomized controlled trial after it is developed. An amended IRB application will be submitted for the pilot intervention test.\r\n
|
USA |
2017-02-21 |
2020-02-21 |
Medical and Health Sciences |
|
Non-degree Award |
|
Laura Bogart
ID:
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GAME CHANGERS: A PILOT INTERVENTION TO EMPOWER HIV CLIENTS AS PREVENTION ADVOCATES IN UGANDA (PHASE 2)
REFNo: SS166ES
Primary objectives include: Assessing preliminary intervention effects on:
a) protective behavior of the HIV-positive clients (condom use, partner concurrency/number of partners, engagement in HIV care, ART adherence)
b) diffusion of prevention messages across the network, as assessed by the content and extent of communication with network members about protective behaviors (condom use, partner concurrency/number of partners, HIV testing, engagement in HIV care, circumcision), HIV disclosure, and HIV stigma
|
USA |
2018-04-11 |
2021-04-11 |
Social Science and Humanities |
|
Non-degree Award |
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Christine Sekaggya-Wiltshire Magdalena Susan
ID:
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VIROLOGICAL & CLINICAL OUTCOME OF ADULTS WITH PRETREATMENT OR ACQUIRED HIV DRUG RESISTANCE
REFNo: HS33ES
To describe \r\n• The virological and clinical outcome one year after detection of virological failure and/or HIV drug resistance within the RHINOS study (RHINOS = Resistance in HIV-infected Individuals in North and South).\r\n\r\nFor RHINOS ART experienced with virological failure +/- resistance mutations:\r\n• Proportion of patients switched and not-switched\r\n• Proportion of patients with virological failure switched and not-switched \r\n• Type and frequency of newly diagnosed resistance mutations in patients switched and not switched \r\n\r\nFor RHINOS ART naïve with pre-treatment resistance mutations:\r\n• Proportion of patients initiated on ART \r\n• Proportion of patients started on any drug to which previous HIVDR was detected \r\n• Proportion of patients with virological failure after ART initiation\r\n
|
Uganda |
2017-02-21 |
2020-02-21 |
Medical and Health Sciences |
|
Non-degree Award |
|
Emmanuel Kiiza Mwesiga Kiiza
ID: UNCST-2019-R001588
|
PREDICTORS OF COGNITIVE IMPAIRMENT AMONG PATIENTS WITH FIRST EPISODE PSYCHOSIS IN UGANDA.
REFNo: HS88ES
i) To determine the genetic (COMT, DISC1, HT2RA, BDNF) and environmental (substance use and childhood trauma) factors associated with cognitive impairment among patients with a psychotic episode for the first time.
ii) To determine the frequency of BDNF gene polymorphism and its association with serum BDNF levels and cognitive impairment among patients with a psychotic episode for the first time.
|
Uganda |
2017-09-20 |
2020-09-20 |
Medical and Health Sciences |
|
Non-degree Award |
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Emmanuel Kiiza Mwesiga Kiiza
ID: UNCST-2019-R001588
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COGNITIVE IMPAIRMENT AMONG PATIENTS WITH A FIRST EPISODE OF PSYCHOSIS IN UGANDA: ASSESSMENT, RISK PROFILE AND IMPACT ON QUALITY OF LIFE.
REFNo: HS142ES
1. To review the evidence on the assessment of cognitive function using brief neuropsychological tests in patients with FEP in sub Saharan Africa.
2. To determine the validity of cognitive assessments delivered using a smart phone application in patients with FEP in Uganda.
3. To determine mean duration and factors associated with resolution of psychotic symptoms among patients with FEP in Uganda.
4. To determine the association between genetic and environmental factors (childhood trauma and DUP), and the development of CI in patients with FEP in Uganda.
5. To determine the association between impairment in specific cognitive domains and quality of life in patients with FEP in Uganda.
|
Uganda |
2019-01-08 |
2022-01-08 |
Medical and Health Sciences |
|
Degree Award |
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Emmanuel Kiiza Mwesiga Kiiza
ID: UNCST-2019-R001588
|
PREVALENCE, CORRELATES AND EXPLANATIONS OF A LONG DURATION OF UNTREATED PSYCHOSIS AMONG ANTIPSYCHOTIC NAÃVE PATIENTS AT BUTABIKA HOSPITAL: A MIXED METHODS STUDY.
REFNo: HS237ES
1. To determine the prevalence and factors associated with a long duration of untreated psychosis among patients with a first episode psychosis at Butabika hospital in Uganda.
2. Achieve a qualitative understanding of influence of prior treatment with alternative and complimentary therapies on duration of untreated psychosis among patients with a first episode of psychosis (FEP) presenting to Butabika hospital in Uganda.
|
Uganda |
2019-01-29 |
2022-01-29 |
Medical and Health Sciences |
|
Non-degree Award |
|
Emmanuel Kiiza Mwesiga Kiiza
ID: UNCST-2019-R001588
|
A link between diet and cognitive function in Ugandan first-episode schizophrenia patients and healthy controls using nutrimetabolomics
REFNo: HS6783ES
3.To determine the effect of FES-specific DIBs generated from nine specific food groups on cognitive function.,2.To examine the modifying effect of non-genetic regulatory factors on dietary intake biomarkers generated in FES patients and healthy controls.,1.To compare dietary intake biomarkers generated from nine food groups in FES patients and healthy controls.,To utilize nutrimetabolomics to examine the link between diet and cognitive function in Ugandan first-episode schizophrenia patients and healthy controls.,
|
Uganda |
2025-12-18 19:57:34 |
2028-12-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Tatiana Morais
ID:
|
"Women’s Talkâ€
REFNo: SS173ES
The main objective of this research project is to understand the camps’ context response to Gender-Based Violence (GBV). The focus will be on what the refugee considers to be the best practices already implemented and what can be improved. Also, Uganda does have a National GBV Database (NGBVD) which makes the country a pioneer in addressing and making visible GBV, thus, this research would like to learn from the Uganda good practices and policies.
|
Portugal |
2018-06-26 |
2021-06-26 |
Social Science and Humanities |
|
Non-degree Award |
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Agnes Kiragga
ID:
|
Tracing non-rEtained HIV PoSitivE Pregnant Women enrolled in Option B+ and ascertaining their BabIeS outcomes (sTEPWISe)
REFNo: HS35ES
Specific Aim 1: Trace women, initiated ART under option B+ who disengaged from care and assess reasons for disengagement, as well as obtain corrected estimates of retention by evaluating the proportion of mothers who have re-engaged or died.\r\nSpecific Aim 2: Assess and compare HIV transmission rates among infants born to retained and disengaged mothers. \r\nSub-aim 2.1. Perform HIV DNA PCR testing on the infants of disengaged women \r\nSub-aim 2.2 Obtain HIV status data on infants of retained women from existing medical records, or by providing HIV DNA-PCR testing for untested-infants or those whose test was performed within the previous month.\r\nSpecific Aim 3: To measure efavirenz (EFV) levels in the blood collected from all re-engaged and a matched sample of retained women. \r\nSpecific Aim 4: To perform genotypic testing among retained and disengaged women with virologic failure defined as viral load ≥1,000 copies/ml in order to describe mutations that are known to confer drug resistance. \r\n
|
Uganda |
2017-05-05 |
2020-05-05 |
Medical and Health Sciences |
|
Non-degree Award |
|
Agnes Kiragga
ID:
|
Men at Gaming Centers: Point of Care HIV and STI Testing
REFNo: HS70ES
• To test the acceptability and feasibility of same day testing of HIV and syphilis testing, test result notification, prevalence of HIV and syphilis, and proportion linked to care among men attending at gaming/betting centers
• To identify the proportion of men involved in other self-reported risky behaviors such as hazardous alcohol intake, illicit drug use, having sex with men and having multiple sexual partners,
• To test the diagnostic performance of the ChemBio duo HIV-syphilis point of care test.
|
Uganda |
2017-05-30 |
2020-05-30 |
Medical and Health Sciences |
|
Non-degree Award |
|
Agnes Kiragga
ID:
|
Locating disengaged HIV positive women on Option B+ and ascertainment of outcomes among their infants
REFNo: HS175ES
1. To describe the pregnancy outcomes and HIV care status among women (and their exposed infants) who initiate Option B+
2. To correct 6 week and 18 month estimates of MTCT through tracing of a random sample of HIV positive women who initiated Option B+ during pregnancy and disengaged from care.
3. To identify factors associated with HIV sero-positivity among infants born to women initiated on Option B+.
4. To establish the frequency of Multiclass Resistance among HIV positive infants born to women initiated on Option B+
5. To estimate the proportion of disengaged women with viral failure and correct estimates of viral suppression (3 rd UN 90 goal) in the facilities.
|
Uganda |
2018-04-04 |
2021-04-04 |
Medical and Health Sciences |
|
Non-degree Award |
|
Agnes Kiragga
ID:
|
A Pilot Test of a Technology-delivered HIV Self-Testing Intervention in Kampala, Uganda
REFNo: HS307ES
1) An established 24-hour call-in center staffed by medical providers who will deliver accurate HIV/STI information, perform pre- and post-test counselling, assist with conducting HIVST and interpreting the HIVST results, and referral and linkage to appropriate post-test prevention and treatment care; and
2) The use of SMS and social media streams – specifically private Facebook and Twitter messages - to “push†theoretically-grounded messages that promote HIVST and provide additional private communication routes between participants and medical provider research staff. The study aims are:
Aim 1: Develop HIVST messages and finalize study procedures and materials with input from a Community Advisory Board (CAB), and beta test the intervention with 6 sexually active Ugandan adults (18-49 years old; 50% female).
Aim 2: Using a pre-post design, assess the feasibility, acceptability and preliminary impact of the HIVST intervention developed in Aim 1 for Ugandan adults (n=100; 70% 18-24 years old, 30% 25-49 years old; 50% female). Feasibility will be assessed by whether enrollment targets are reached and the proportion of completed 1- and 3-month follow-ups calls. Acceptability items will be gathered at 1- and 3-month assessments. Preliminary impact will be determined by the percentage of participants who perform HIVST in the 3 months after enrollment.
Aim 3: Analyze process indicators of the overall use of the HIVST intervention, including the number of HIVST kits requested, the volume of callers requesting HIVST during the study period, the number of persons calling for assistance with self-testing procedures, the number of post-test counseling calls received, and the number of persons linked to follow-up prevention and care services.
|
Uganda |
2019-02-26 |
2022-02-26 |
Medical and Health Sciences |
|
Non-degree Award |
|
Agnes Kiragga
ID:
|
Reproductive Health Empowerment through Telehealth
REFNo: HS425ES
1-With input from a Community Advisory Board develop a user-centered mobile-based reproductive health content targeted for men through SMS, interactive voice response.
2-Assess the feasibility and acceptability of the Men’s Telehealth Information Package (mTIP) on uptake of family planning and reproductive health services.
3-Assess the men’s knowledge and attitudes towards family planning following receipt of the Men’s Telehealth Information Package (mTIP)
4-Assess uptake of and attitudes towards FP and couple communication among women whose spouses received the Men’s Telehealth Information Package (mTIP) intervention.
|
Uganda |
2019-08-06 |
2022-08-06 |
Medical and Health Sciences |
|
Non-degree Award |
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