Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Lara Rosenoff Gauvin Shelley
ID:
We are Sons and Daughter of Bwoc: Refusal and Land Rights Protections in Rural Post-Conflict Acoliland, Northern Uganda.
REFNo: SS112ES

To understand: What do processes involved in writing a clan-based non-profit foundation’s constitution (in a previously oral tradition of indigenous governance) do for relatedness in the post-conflict, land-pressured context? After it is written, and circulated, what does the document do for relatedness in context? How does/can it mediate both between sons and daughters of the clan, and between clan members, National Government, and foreign companies, as examples? And finally, how do real and perceived land pressures impact ideas and practices of relatedness, and thus social repairing and particular notions of refusal, through time.
Canada 2017-11-14 2020-11-14 Social Science and Humanities Non-degree Award
John  Lule Ronald
ID:
Baseline Study for an Adolescent HIV and SRHR Programme
REFNo: HS23ES

The objective of this study is to establish baseline values and qualitative information on select project indicators. This information will serve as a basis for Alliance and CHAU to set targets and track changes and progress against these indicators throughout the project period. This information may also serve Alliance and CHAU to inform and shape programming as well as READY project contribution to Uganda national SRHR and HIV outcomes and targets.
Uganda 2017-01-10 2020-01-10 Medical and Health Sciences Non-degree Award
Robert  Lukande
ID:
Post-Mortem Assessment of Pathogen and Anti-infective Distribution and Responses i HIV-Positive Patients
REFNo: HS24ES

• Use histopathology to determine pathogen (viral, fungal) distribution within and across tissue compartments\r\n• Improve diagnostic methods for HIV and AIDS-related infections\r\n• Determine distribution of anti-infective agents within and across tissue compartments\r\n
Uganda 2016-12-13 2019-12-13 Medical and Health Sciences Non-degree Award
Priscilla Namaganda
ID: UNCST-2019-R001653
Oncogenic viral proteins associated with lymphomas at the Uganda Cancer Institute, Uganda, a comparison between HIV-associated and non-HIV-associated lymphomas.
REFNo: HS4342ES

To describe the oncogenic viral protein patterns among lymphomas at the Uganda Cancer Institute (UCI), comparing HIV-associated and non-HIV-associated lymphomas.,To determine the effect of oncogenic viral proteins on treatment outcomes of lymphoma among patients, HIV infected and uninfected at the UCI. ,
Uganda 2024-11-13 17:04:50 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anne Kantel
ID:
Situating Legitimacy: Encounters between State-Based and Local Fisheries Lifeworlds in Uganda
REFNo: SS48ES

Questions of how to design successful environmental management systems have motivated research in anthropology, political geography and international relations for decades. To the extent that ‘success’ depends on compliance, this raises a fundamental question: When and why do people comply with regulations governing the commons? I address this issue from a specific angle: Why do the same natural management policies fail in some spaces, while they succeed in others? Using the exemplifying case of fisheries management in Uganda, I argue that variance in compliance rates with state policies can be understood by studying the constitution and interaction of different lifeworlds and the effects of such encounters on the perceived cultural legitimacy of state policies in specific spaces. Existing studies suggest that if state-based lifeworlds are incongruent with local fisheries lifeworlds, the perceived cultural legitimacy of, as well as compliance rates with, government policies in these spaces are low.
Germany 2017-02-21 2020-02-21 Social Science and Humanities Degree Award
Aggrey Semeere Semwendero
ID: UNCST-2019-R001648
New approaches for the diagnosis of Kaposi's sarcoma
REFNo: HS28ES

To evaluate two novel diagnostic approaches for KS that may be eventually deployed with portable, point-of-care techniques. One approach features confocal microscopy and the other approach uses nucleic acid amplification. We shall compare these new approaches with the gold standard of histology from a traditional skin punch biopsy to determine the sensitivity and specificity of each new approach.
Uganda 2016-12-13 2019-12-13 Medical and Health Sciences Non-degree Award
Aggrey Semeere Semwendero
ID: UNCST-2019-R001648
ESTIMATION AND EXPLANATIONS FOR THE HYPERTENSION SCREENING GAP AMONG HIV-INFECTED PATIENTS IN HIV PRIMARY CARE.
REFNo: HS118ES

1. Estimate the screening gap for hypertension among HIV-infected adults on ART attending Uganda Cares HIV primary care clinics in Masaka, Rakai and the St. Balikudembe Clinic in Kampala, Uganda over 12 months. 2. Document explanations for the screening gap for hypertension from the perspective of health providers at the Uganda Cares HIV primary care clinic in Masaka, Rakai and St. Balikudembe Clinic in Kampala, Uganda.
Uganda 2017-11-28 2020-11-28 Medical and Health Sciences Non-degree Award
Aggrey Semeere Semwendero
ID: UNCST-2019-R001648
EVALUATION OF THE USE OF TELEDERMATOLOGY AMONG PRIMARY CARE PATIENTS IN KAMPALA
REFNo: HS3655ES

Aim 3: Define the distribution of dermatologic diagnoses that arise in primary care settings in which TD is used and their subsequent management. ,Aim 2: Evaluate the barriers and facilitators to implementation of the TD service,Aim 1: Describe the utilization of TD in ambulatory care settings. ,
Uganda 2024-02-02 11:24:53 2027-02-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Aggrey Semeere Semwendero
ID: UNCST-2019-R001648
Precision Imaging to Evaluate Kaposi Sarcoma (PRIME-KS)
REFNo: HS5498ES

•Aim 1: Refine SkinScan3D Technology and Usage Protocols for Routine KS Imaging:
•Aim 2: Compare Reproducibility and Accuracy of KS Lesion Size Measurements Between SkinScan3D and Current Standard of Care Measurement.
•Aim 3: Validate and Optimize SkinScan3D Clinical Workflow in Real-World Settings.

Uganda 2025-04-11 16:47:49 2028-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Aggrey Semeere Semwendero
ID: UNCST-2019-R001648
PATIENT AND PROVIDER PERCEPTIONS, EXPERIENCES, AND INTERVENTION SUGGESTIONS AFTER HIV/AIDS CARE FUNDING REDUCTIONS
REFNo: HS7138ES

To characterize comprehension of U.S. funding reduction for HIV/AIDS care and the implications on care among persons living with HIV.
2. To determine the initial impact of U.S. funding reductions for HIV/AIDS care by eliciting the experiences of persons living with HIV and their healthcare providers.
3. To understand perceptions regarding proposed or enacted interventions to maintain care after U.S. HIV/AIDS care funding reduction among providers and persons living with HIV.
Uganda 2026-04-10 15:36:15 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sarah Lofgren
ID: UNCST-2019-R001647
The Growth Study- Group Therapy In HIV For Depression In Uganda
REFNo: HS493ES

Determine if depression, which persists after depression treatment at 26 weeks, is associated with increased innate inflammation in a prospective cohort of HIV-infected Ugandans receiving SSRIs in which group psychotherapy is initiated.
USA 2019-12-09 2022-12-09 Medical and Health Sciences Non-degree Award
Sarah Lofgren
ID: UNCST-2019-R001647
Supervised Treadmill intervention to Reduce Inflammation and Depression through Exercise in HIV: The STRIDE Pilot Study
REFNo: HS3358ES

The objective of this study is to determine the feasibility and acceptability of an aerobic intervention via a treadmill among individuals with HIV and depression in Uganda.
3.1 Primary Endpoint: Feasibility and acceptability of Exercise as a treatment for depression in Ugandans with HIV. This will be measured by:
-Percent completion of the prescribed aerobic exercise intervention, as assessed by research staff logging participation.

3.2 Secondary Endpoint(s)/ Outcome(s):
- acceptability of the intervention assessed via a post intervention survey
-feasibility and acceptability of using a wearable exercise tracker to assess the volume of exercise, based on calories burned and steps achieved, during the intervention period among Ugandans with HIV and depression.
- measure the mean and standard deviation of baseline and 8-week serum BDNF and IL-6 level to estimate an effect size and power a future study.
- measure the mean and standard deviation of baseline and 8-week depression score via PHQ-9 to estimate an effect size and power a future study.
- measure the mean and standard deviation in aerobic fitness baseline and at 8 weeks measured via METS/watts achieved and total time/distance to estimate the effect size for a future intervention.
USA 2024-02-26 13:41:23 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Robert Buwule Stalone
ID:
Re-Engineering Research and Innovation Information in University Libraries in Uganda for Small and Medium Enterprises (SMEs) in the Agricultural Sector
REFNo: IS6ES

a) To investigate how University libraries in Uganda are facilitating access to Research and Innovation information for use by Small and Medium Enterprises in the agricultural sector in Uganda.\r\nb) To find out the extent to which University libraries in Uganda repackage Research and Innovation information for use by Small and Medium Enterprises in the agricultural sector in Uganda.
Uganda 2017-02-24 2020-02-24 Social Science and Humanities Degree Award
Robert Buwule Stalone
ID:
Use of COVID-19 surveillance applications in Uganda
REFNo: SS1477ES

To design a health-based ICT COVID-19 surveillance framework for community health,To establish the drivers and barriers of adopting health-based ICT surveillance applications in Uganda,To examine the adoption and integration of the surveillance applications in the community health practices in Uganda,To assess the efficacy of the existing health-based ICT surveillance applications in the communities in Uganda,To identify health-based ICT surveillance applications developed to mitigate the COVID-19 pandemic in Uganda,To establish the level of application of Covid-19 Surveillance applications ICT innovations in community health during the COVID-19 pandemic in Uganda with a view of suggesting a health-based ICT framework for community health,
Uganda 2022-11-29 12:33:19 2025-11-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Megan Swanson
ID:
Identifying Barriers and Facilitators to Cervical Cancer Care in Kampala, Uganda
REFNo: HS29ES

The overall goal of this project is to identify the barriers to cervical cancer care in Kampala, Uganda. Specific aims are as follows:\r\n\r\nAim 1: Describe the prevalence of cervical cancer by stage and factors associated with late versus early-stage diagnoses.\r\n\r\nAim 2: Describe the intervals of time in the process of obtaining care for cervical cancer.\r\n\r\nAim 3: Describe the challenges doctors at referral hospitals face in providing cervical cancer care.\r\n
USA 2017-02-21 2020-02-21 Medical and Health Sciences Non-degree Award
ALEX KAYONGO
ID: UNCST-2019-R001641
In-vitro Susceptibility of Broncho-alveolar-derived Macrophages to Mycobacterium tuberculosis among persistently IGRA-negative TB household contacts in Uganda
REFNo: HS1767ES

Study Aim:
Phenotypic characterization of persistently IGRA-negative individuals based on in-vitro killing of luciferase-expressing recombinant Mtb in broncho-alveolar lavage.

Specific Objectives
1. To demonstrate in-vitro BAL and blood monocyte derived macrophage killing of luciferase-expressing recombinant Mtb among persistently IGRA-negative individuals.

2. To validate in-vitro BAL-derived macrophage killing assays using virulent Mtb strains identified from “the Ugandan TB cohort.

3. To compare BAL-derived macrophage expression profiles for selected cytokines, phagocytic receptors, phagosome maturation and microbial killing genes between IGRA-negative and positive individuals.

4. To compare levels of selected macrophage cytokines and chemokines in BAL supernatant between IGRA-negative and positive individuals.
Uganda 2022-03-03 2025-03-03 Medical and Health Sciences Non-Clinical Trial Degree Award
ALEX KAYONGO
ID: UNCST-2019-R001641
Airway Microbiome and Th17-mediated inflammation in COPD among HIV-infected individuals in a rural Ugandan cohort ACRONYM: HIV-LUNG MICROBIOME (HLM) study
REFNo: HS2035ES

Study aim:
To investigate airway microbiome-driven Th17 mediated inflammation in COPD among HIV-infected individuals

Specific objectives
1. To establish a relationship between airway microbiome and Th17/Treg cellular phenotypes among HIV-infected individuals with COPD.

2. To investigate bacterial mediated Th17 up-regulation of pro-inflammatory genes among HIV-infected individuals with COPD.

3. To investigate the role of bacterial outer membrane vesicles (OMVs) in mediating dysbiosis driven Th17 immune responses among HIV individuals.

Uganda 2022-02-10 2025-02-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ALEX KAYONGO
ID: UNCST-2019-R001641
Mechanisms of Immune Resistance to Mycobacterium tuberculosis
REFNo: HS3165ES

Aims: In this study, we will immuno-phenotype airway microbiome signatures as innate, Th1, Th2, Th17, or Treg-inducing using a chronic airway inflammation population. We will then determine the association between airway microbiome, M.tb-specific IFN-gamma responses, and M.tb burden based on GeneXpert status to underpin immune protective microbial signatures. Finally, we will validate identified immune-protective microbial signatures as a proxy for IFN-gamma reactivity and TB immune protection in a separate cohort of persistently QFT-negative individuals compared to household LTBI controls.
Uganda 2023-10-13 11:01:43 2026-10-13 Medical and Health Sciences Non-Clinical Trial Degree Award
ALEX KAYONGO
ID: UNCST-2019-R001641
Clonotyping Airway T-cells to Uncover Microbiome-Specific Inflammotypes in HIV-Associated COPD
REFNo: HS6625ES

Study Aim:
To investigate the airway microbiome-specific inflammotypes in COPD among HIV-infected individuals in a rural Uganda.

Specific objectives
1.To determine, in vitro, the CD4+T-cell clonotypic library specific to airway bacterial species associated with COPD among HIV-infected individuals in rural Uganda.

2.To determine, ex vivo, the microbiome-specific clonotypic landscape of BAL-derived CD4+T cells from a cohort of individuals stratified by HIV and COPD in rural Uganda.

3.To validate airway microbiome-specific inflammotypes among individuals with COPD transitioning from stable disease to exacerbation and back to stable disease.

Uganda 2025-10-29 12:47:04 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Imelda Namagembe
ID:
ETHICAL CHALLENGES ENCOUNTERED BY RESEARCHERS AND INSTITUTIONAL REVIEW BOARD MEMBERS IN EMERGENCY OBSTETRICS –GYNAECOLOGY CARE RESEARCH: A CASE STUDY OF MAKERERE COLLEGE OF HEALTH SCIENCES/MULAGO HOSPITAL, UGANDA.
REFNo: HS31ES

General Objective:\r\nTo explore and document ethical challenges encountered in emergency obstetrics-gyneacology research by researchers and IRB members at Makerere College of Health Sciences/Mulago Hospital, Uganda".\r\nSpecific objectives\r\n1) To explore the ethical challenges encountered in emergency obstetrics-gynaecology research by researchers at Makerere College of Health Sciences and Mulago Hospital.\r\n2) To explore the ethical and operational challenges encountered by IRB members when reviewing / monitoring research in emergency obstetrics-gynecology. \r\n3) To document the strategies used by both researchers and IRB members to handle the ethical and operational challenges encountered in emergency obstetrics-gynecology research\r\n
Uganda 2017-01-31 2020-01-31 Medical and Health Sciences Non-degree Award
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