Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Simon  Sensalire
ID:
THE FUNCTIONALITY AND EFFECTIVENESS OF MOTHER BABY CARE POINTS (MCBPS): AN EVALUATION OF THE INTERVENTION
REFNo: HS45ES

The main purpose of the proposed evaluation is to explore into the setup, functionality and user perspectives of benefits and gaps of the MB care points in line with the PMTCT initiative, and inform improvements in their functionality. Specifically, the assessment aims; a) To identify of key activities pertaining to the formation of MBCPs and extent of compliance to the guidelines b) To determine the extent of implementation of recommended activities for the functionality of MBCPs c) To explore perceptions of midwives about MBCP with specific emphasis on feasibility, acceptability, uptake and retention. d) Assess the clinic system in terms of scope of services, quality of care provision and documentation e) To explore perceptions of mothers in terms of satisfaction and acceptability of MBCPs
Uganda 2017-03-28 2020-03-28 Medical and Health Sciences Non-degree Award
Simon  Sensalire
ID:
Improving Quality of Care of Maternal and Child Services through Result Based Financing (RBF): A Health Facility Based Case Control Survey
REFNo: HS43ES

ï‚§ To assess whether the RBF payment method, when implemented, improves the quality of ANC, delivery and PNC services compared to usual financing methods ï‚§ To assess health provider perceptions and expectations of whether other services have, or will be impacted by the RBF intervention ï‚§ Assess the effect of RBF on practices of midwives through observing service delivery ï‚§ Determine whether women experience of delivery and PNC services reflect impact of the intervention on quality of MNCH services? ï‚§ To draw lessons about RBF in the context of Uganda and inform RBF rollout strategy? ï‚§ Contribute to learning on improvement strategies for MNCH
Uganda 2017-03-28 2020-03-28 Medical and Health Sciences Non-degree Award
Simon  Sensalire
ID:
A TREND ANALYSIS OF BEHAVIORAL CHANGE AMONG GIRLS AND YOUNG WOMEN IN THE DREAMS PILOT DISTRICTS
REFNo: SS61ES

Generally the study aims at assessing changes in sexual behavior of girls and uptake of HIV related services Specifically, the study aims; 1) To determine girls exposure to the DREAMS behavior change communication package (BCC) 2) To determine changes in knowledge and risk perception of HIV among girls under DREAMS intervention 3) To determine changes in sexual behavior of girls over time 4) To determine levels of contraceptive use among girls/young women 5) To determine the various forms of violence experienced by the girls and the actions taken by the victims 6) To determine the various forms of parental and partner support and how it influences the behavior of the girls? 7) To determine HCT and disclosure among girls who have tested for HIV 8) To assess the influence of DREAMS on the girls behavior over the pilot period
Uganda 2017-04-11 2020-04-11 Social Science and Humanities Non-degree Award
Simon  Sensalire
ID:
Assessment of Effectiveness and Cost-effectiveness of the Quality Improvement Guide on Maternal and Newborn Care in Uganda
REFNo: HS162ES

1 Evaluate the change in QI-related actions (defined as; establishing improvement team, identifying gaps in quality of care and particular barriers causing the gap, deciding what to improve, plan, test and implement interventions to address identified gap, routinely monitor the progress of improvement and institutionalize improvement and successful changes in the facility) and knowledge among health care providers and managers from targeted health facilities using different implementation strategies vs business as usual (control group). 2 Determine the change in quality of maternal and newborn care processes (defined as every patient receiving the recommended services every time it is appropriate) and outcomes from pre-intervention to post-intervention in health facilities which have been exposed to the three different implementation strategies. 3 Determine the incremental cost-effectiveness ratio of the different implementation strategies in terms of expenditure per unit of patient care improvement achieved by the implementation strategy to each other and the control group with no incremental costs related to particular control group strategy. 4 Explore key informants perceptions of and experiences with the different intervention strategies.
Uganda 2018-03-06 2021-03-06 Medical and Health Sciences Non-degree Award
David  Coppock Layne
ID:
Climate Change Perceptions and Adaptation Among Small-Scale Farmers in Uganda: A Community-Based Approach
REFNo: SS44ES

\r\n 1.) Determine if small-scale farmers in Uganda perceive the climate to be changing, and if so, determine how and why they perceive it to be changing.\r\n\r\n 2.) Determine what adaptive actions, if any, small-scale farmers in Uganda are taking in response to the changes in the climate they perceive.\r\n\r\n 3.) Determine what resources small-scale farmers in Uganda need to enhance their resilience to climate change. \r\n\r\n 4.) Determine how the climate-change perceptions, adaptive actions, and resource needs vary with the location where small-scale Ugandan farmers reside, particularly between urban and rural locales. \r\n
USA 2017-04-20 2020-04-20 Social Science and Humanities Degree Award
Sarah O'Sullivan
ID:
Undisclosed Stigma: the Politics of the Ordinary, ARV Adherence, and Development in Post-Conflict Northern Uganda
REFNo: SS47ES

(1) to understand how the history of war and aid-dependency in northern Uganda, along with the recent introduction of accessible anti-retroviral medication for people living with HIV contributions to ongoing stigma towards with living with HIV. (2) To provide a close qualitative analysis of how stigma associated with HIV post-ARV rollout affects HIV-positive people and their families. (3) to understand how severe aid-dependency and the proliferation of development initiatives in northern Uganda influences the expectations towards how people living with HIV on ARVs should behave as productive citizens contributing to northern Uganda’s post-conflict restructuring.
Canada 2016-12-13 2019-12-13 Social Science and Humanities Degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
An Evaluation of the Association of Anaesthetists of Great Britain & Ireland Uganda Fellowship Programme.
REFNo: HS27ES

The research objectives are:\r\n\r\n1. To quantify the number of trained physician anaesthetists now working in Uganda, including their roles and responsibilities.\r\n\r\n2. To explore what impact the AAGBI Uganda Fellowship Programme has had on the standards of training in anaesthesia and patient care in Uganda.\r\n\r\n3. To explore how perceptions of the specialty of anaesthesia in Uganda have changed over the duration of the AAGBI Uganda Fellowship Programme.\r\n\r\n4. To understand the impact that different partnerships have had on the specialty of anaesthesia in Uganda over the last 10 years.\r\n
UK 2016-12-13 2019-12-13 Medical and Health Sciences Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
A cluster randomised trial to determine whether increased postoperative surveillance of adult African surgical patients reduces postoperative mortality
REFNo: HS298ES

Primary objective - To determine whether increased postoperative surveillance reduces in-hospital mortality in high-risk adult surgical patients aged 18 years and over in Africa. Primary outcome measure - In-hospital mortality, censored at 30 days if the patient is still alive and in-hospital. Secondary objective - To determine whether increased postoperative surveillance reduces the incidence of the composite of severe in-hospital complications and mortality in high-risk adult surgical patients aged 18 years and over in Africa. Secondary outcome measure - Composite of severe in-hospital complications and mortality, censored at 30 days if the patient is still alive and in-hospital.
UK 2019-04-16 2022-04-16 Medical and Health Sciences Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
Family SuppleMented pAtient monitoRing afTEr suRgery (SMARTER) pilot trial
REFNo: HS944ES

To develop a training and support intervention, in accordance with the MRC complex intervention framework, to train family carers to perform and document basic vital signs, to supplement routine monitoring of patients by nursing staff, whilst they provide personal care to their relatives after surgery and to evaluate the effect of this intervention on frequency of documented vital signs for patients in the first three days after surgery in a stepped-wedge cluster trial.
To evaluate compliance with the trial intervention, and how this changes over the duration of the trial.
To evaluate the effect of the intervention on in-patient mortality, to inform the design of a subsequent international clinical trial across Africa
UK 2021-03-23 2024-03-23 Medical and Health Sciences Degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
African Surgical Outcomes Study in Paediatric patients (ASOS-Paeds)
REFNo: HS2179ES

In paediatric surgical patients < 18 years in Africa: To determine the association between pre-operative, intra-operative and facility factors with postoperative complications and death. ,In paediatric surgical patients < 18 years in Africa: To determine the incidence of intraoperative severe critical incidents,,In paediatric surgical patients < 18 years in Africa: To determine the in-hospital postoperative mortality rate up to 30 days post-surgery,,To determine the incidence of in-hospital postoperative complications up to 30 days post-surgery in paediatric surgical patients <18 years in Africa,
UK 2022-05-27 18:55:24 2025-05-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
The African Critical Illness Outcomes Study
REFNo: HS3338ES

To determine the availability of resources for essential emergency and critical in African hospitals.,To investigate the association between the provision of essential emergency and critical care to critically ill patients and mortality.,To estimate the proportion of critically ill patients who receive essential emergency and critical care.,To establish the mortality rate of the critically ill patients and those who are not critically ill.,To establish the proportion of adult (18 years or older) inpatients in African hospitals that are critically ill.,
UK 2023-10-30 21:08:01 2026-10-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study.
REFNo: HS5389ES

To evaluate the impact of a structured antimicrobial review on rates of antimicrobial density, redundancy and associated indicators of antimicrobial utilisation.,To determine whether a structured antimicrobial review can be implemented in LMIC ICUs,
UK 2025-01-31 7:20:18 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
‘5 Rs to Rescue’ A quality improvement initiative with a cluster trial evaluation and embedded process evaluation
REFNo: HS5020ES

To evaluate the effect of the QI intervention on: 1. 30 day in-hospital mortality. 2. Duration of hospital stay.,To evaluate whether implementation of the ‘5 Rs to Rescue’ quality improvement intervention increases surveillance for patients at risk of ‘failure to rescue’ after surgery in hospitals in Africa.,
UK 2025-01-22 12:30:25 2028-01-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
Assessing the bottlenecks for coverage of Essential Emergency and Critical Care in Uganda, Tanzania, Ethiopia, and South Africa
REFNo: HS6924ES

To determine the underlying causes and suggested solutions of these bottlenecks.,To determine the implementation bottlenecks for the provision of EECC in public hospitals in Uganda, Tanzania, Ethiopia and South Africa ,To investigate the bottlenecks, and their underlying determinants, for the provision of EECC in hospitals in Uganda, Tanzania, Ethiopia and South Africa,
UK 2026-01-19 13:39:06 2029-01-19 Medical and Health Sciences Non-degree Award
Lara Rosenoff Gauvin Shelley
ID:
We are Sons and Daughter of Bwoc: Refusal and Land Rights Protections in Rural Post-Conflict Acoliland, Northern Uganda.
REFNo: SS112ES

To understand: What do processes involved in writing a clan-based non-profit foundation’s constitution (in a previously oral tradition of indigenous governance) do for relatedness in the post-conflict, land-pressured context? After it is written, and circulated, what does the document do for relatedness in context? How does/can it mediate both between sons and daughters of the clan, and between clan members, National Government, and foreign companies, as examples? And finally, how do real and perceived land pressures impact ideas and practices of relatedness, and thus social repairing and particular notions of refusal, through time.
Canada 2017-11-14 2020-11-14 Social Science and Humanities Non-degree Award
John  Lule Ronald
ID:
Baseline Study for an Adolescent HIV and SRHR Programme
REFNo: HS23ES

The objective of this study is to establish baseline values and qualitative information on select project indicators. This information will serve as a basis for Alliance and CHAU to set targets and track changes and progress against these indicators throughout the project period. This information may also serve Alliance and CHAU to inform and shape programming as well as READY project contribution to Uganda national SRHR and HIV outcomes and targets.
Uganda 2017-01-10 2020-01-10 Medical and Health Sciences Non-degree Award
Robert  Lukande
ID:
Post-Mortem Assessment of Pathogen and Anti-infective Distribution and Responses i HIV-Positive Patients
REFNo: HS24ES

• Use histopathology to determine pathogen (viral, fungal) distribution within and across tissue compartments\r\n• Improve diagnostic methods for HIV and AIDS-related infections\r\n• Determine distribution of anti-infective agents within and across tissue compartments\r\n
Uganda 2016-12-13 2019-12-13 Medical and Health Sciences Non-degree Award
Priscilla Namaganda
ID: UNCST-2019-R001653
Oncogenic viral proteins associated with lymphomas at the Uganda Cancer Institute, Uganda, a comparison between HIV-associated and non-HIV-associated lymphomas.
REFNo: HS4342ES

To describe the oncogenic viral protein patterns among lymphomas at the Uganda Cancer Institute (UCI), comparing HIV-associated and non-HIV-associated lymphomas.,To determine the effect of oncogenic viral proteins on treatment outcomes of lymphoma among patients, HIV infected and uninfected at the UCI. ,
Uganda 2024-11-13 17:04:50 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anne Kantel
ID:
Situating Legitimacy: Encounters between State-Based and Local Fisheries Lifeworlds in Uganda
REFNo: SS48ES

Questions of how to design successful environmental management systems have motivated research in anthropology, political geography and international relations for decades. To the extent that ‘success’ depends on compliance, this raises a fundamental question: When and why do people comply with regulations governing the commons? I address this issue from a specific angle: Why do the same natural management policies fail in some spaces, while they succeed in others? Using the exemplifying case of fisheries management in Uganda, I argue that variance in compliance rates with state policies can be understood by studying the constitution and interaction of different lifeworlds and the effects of such encounters on the perceived cultural legitimacy of state policies in specific spaces. Existing studies suggest that if state-based lifeworlds are incongruent with local fisheries lifeworlds, the perceived cultural legitimacy of, as well as compliance rates with, government policies in these spaces are low.
Germany 2017-02-21 2020-02-21 Social Science and Humanities Degree Award
Aggrey Semeere Semwendero
ID: UNCST-2019-R001648
New approaches for the diagnosis of Kaposi's sarcoma
REFNo: HS28ES

To evaluate two novel diagnostic approaches for KS that may be eventually deployed with portable, point-of-care techniques. One approach features confocal microscopy and the other approach uses nucleic acid amplification. We shall compare these new approaches with the gold standard of histology from a traditional skin punch biopsy to determine the sensitivity and specificity of each new approach.
Uganda 2016-12-13 2019-12-13 Medical and Health Sciences Non-degree Award
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