JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
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A phase II/III, open-label, randomized clinical trial to evaluate the efficacy and safety of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in life-threatening postpartum haemorrhage (PPH) in reducing adverse maternal outcome compared to standard of care in Uganda.
REFNo: HS3240ES
To assess the time to insert the REBOA.,To assess if the proportion of participants with either maternal death and/or emergency hysterectomy is lower in the intervention arm when excluding ‘inevitable’ hysterectomies due to either an irreparable uterine rupture, a pathological placenta growing into the uterus (placenta accreta, increta or percreta) or a pathological uterus, such as a bicorne uterus or one with very large fibroids.,To assess if post-partum haemoglobin concentration is higher in in the intervention arm compared to the comparator arm,To assess if the number of blood transfusion units is lower in the intervention arm compared to the comparator arm.,To assess if the number of participants with acute kidney injury is lower in the intervention arm compared to the comparator arm,To assess if the proportion of participants with maternal deaths is lower in the intervention arm compared to the comparator arm.,To assess if the proportion of participants with emergency hysterectomy, is lower in the intervention arm compared to the comparator arm., To assess the safety of REBOA in a national referral hospital in a low-income country like Uganda.,To assess if the proportion of participants with either maternal death and/or emergency hysterectomy, can be decreased from 50 % in the comparator arm (using standard of care alone) to 30 % or less in the intervention arm (using REBOA). ,
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Uganda |
2023-11-13 12:15:41 |
2026-11-13 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
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Community survey on the effect of access to water on the maternal and child health of Mutugunda Population
REFNo: HS3505ES
To survey the effect of access to water and women empowerment on maternal and child health of Mutugunda Population,To explore the role of the NCENT group as a potential avenue to improve maternal and child health outcomes.,To describe the impact of water tanks on maternal and child health and community health in Mutugunda,To describe the access and use of maternal and child health services by women and children living in Mutugunda,
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Uganda |
2024-04-17 18:30:39 |
2027-04-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
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Heat-stable carbetocin for the treatment of postpartum haemorrhage: a phase III, randomized, double-blind, active controlled, multicountry, multicentre, non-inferiority trial
REFNo: HS5151ES
To evaluate the cost-effectiveness of the PPH treatment with HSC compared to PPH treatment with oxytocin, if HSC is proven non-inferior. ,To evaluate the comparative effects of HSC versus oxytocin on haemodynamic outcomes when used for PPH treatment in women receiving HSC for prophylaxis; ,The primary objective of this trial is to evaluate whether HSC is non-inferior to oxytocin for treatment of PPH in women who receive HSC for PPH prophylaxis, in the prevention of additional blood loss of 500 ml or more at 90 min following randomization. ,
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Uganda |
2024-11-13 17:36:53 |
2027-11-13 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Rieko Shibata
ID:
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Understanding dynamics and diversity of smallholder farmers' innovation characteristics and processes in Agricultural Innovation System in Uganda
REFNo: SS43ES
The objectives of the research are 1. to understand local agricultural innovation types and processes of smallholder farmers with different socioeconomic characteristics, in relation to the changing socio-economic and environmental conditions in Uganda, 2. to understand implications of innovations on the livelihoods of farmers with different socioeconomic characteristics, and 3. to critically analyse its relevance and effectiveness of current AIS and its practices in Sub-Saharan Africa, particularly in Uganda, in relaiton to local innovation processes, and identify practical solutions.
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Japan |
2016-12-21 |
2019-12-21 |
Social Science and Humanities |
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Degree Award |
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Anna Eisenstein
ID:
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Health Interactions in South Western Uganda
REFNo: SS46ES
The objectives of this research are: 1. To identify the interactional cues that patients interpret as “care"; 2. To document the relevance of linguistic phenomena to how patients and practitioners negotiate authority in medical settings; and 3. To identify interactional variables that impact patient engagement in medical care/treatment.
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USA |
2016-12-13 |
2019-12-13 |
Social Science and Humanities |
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Degree Award |
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Simon Sensalire
ID:
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Increasing TB Case Notification and Documenting Improvement and Cost Effective Strategies in Northern Uganda: A Facility Based Intervention Case-Control Study
REFNo: HS22ES
• To quantify changes in levels of TB case detection and notification in intervention and control facilities following specific intervention.\r\n• To quantify changes in the evaluation of TB presumptive case and enrollment of confirmed TB cases on treatment at both case and control facilities following specific interventions \r\n• To document successful improvement strategies for TB notification at intervention facilities\r\n• To provide in-depth knowledge of barriers and enablers to TB case notification\r\n• To measure cost of implementing improvement strategies for in the intervention facilities \r\n
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Uganda |
2016-12-21 |
2019-12-21 |
Medical and Health Sciences |
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Non-degree Award |
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Simon Sensalire
ID:
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THE FUNCTIONALITY AND EFFECTIVENESS OF MOTHER BABY CARE POINTS (MCBPS): AN EVALUATION OF THE INTERVENTION
REFNo: HS45ES
The main purpose of the proposed evaluation is to explore into the setup, functionality and user perspectives of benefits and gaps of the MB care points in line with the PMTCT initiative, and inform improvements in their functionality.
Specifically, the assessment aims;
a) To identify of key activities pertaining to the formation of MBCPs and extent of compliance to the guidelines
b) To determine the extent of implementation of recommended activities for the functionality of MBCPs
c) To explore perceptions of midwives about MBCP with specific emphasis on feasibility, acceptability, uptake and retention.
d) Assess the clinic system in terms of scope of services, quality of care provision and documentation
e) To explore perceptions of mothers in terms of satisfaction and acceptability of MBCPs
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Uganda |
2017-03-28 |
2020-03-28 |
Medical and Health Sciences |
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Non-degree Award |
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Simon Sensalire
ID:
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Improving Quality of Care of Maternal and Child Services through Result Based Financing (RBF): A Health Facility Based Case Control Survey
REFNo: HS43ES
 To assess whether the RBF payment method, when implemented, improves the quality of ANC, delivery and PNC services compared to usual financing methods
 To assess health provider perceptions and expectations of whether other services have, or will be impacted by the RBF intervention
 Assess the effect of RBF on practices of midwives through observing service delivery
 Determine whether women experience of delivery and PNC services reflect impact of the intervention on quality of MNCH services?
 To draw lessons about RBF in the context of Uganda and inform RBF rollout strategy?
 Contribute to learning on improvement strategies for MNCH
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Uganda |
2017-03-28 |
2020-03-28 |
Medical and Health Sciences |
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Non-degree Award |
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Simon Sensalire
ID:
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A TREND ANALYSIS OF BEHAVIORAL CHANGE AMONG GIRLS AND YOUNG WOMEN IN THE DREAMS PILOT DISTRICTS
REFNo: SS61ES
Generally the study aims at assessing changes in sexual behavior of girls and uptake of HIV related services
Specifically, the study aims;
1) To determine girls exposure to the DREAMS behavior change communication package (BCC)
2) To determine changes in knowledge and risk perception of HIV among girls under DREAMS intervention
3) To determine changes in sexual behavior of girls over time
4) To determine levels of contraceptive use among girls/young women
5) To determine the various forms of violence experienced by the girls and the actions taken by the victims
6) To determine the various forms of parental and partner support and how it influences the behavior of the girls?
7) To determine HCT and disclosure among girls who have tested for HIV
8) To assess the influence of DREAMS on the girls behavior over the pilot period
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Uganda |
2017-04-11 |
2020-04-11 |
Social Science and Humanities |
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Non-degree Award |
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Simon Sensalire
ID:
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Assessment of Effectiveness and Cost-effectiveness of the Quality Improvement Guide on Maternal and Newborn Care in Uganda
REFNo: HS162ES
1 Evaluate the change in QI-related actions (defined as; establishing improvement team, identifying gaps in quality of care and particular barriers causing the gap, deciding what to improve, plan, test and implement interventions to address identified gap, routinely monitor the progress of improvement and institutionalize improvement and successful changes in the facility) and knowledge among health care providers and managers from targeted health facilities using different implementation strategies vs business as usual (control group).
2 Determine the change in quality of maternal and newborn care processes (defined as every patient receiving the recommended services every time it is appropriate) and outcomes from pre-intervention to post-intervention in health facilities which have been exposed to the three different implementation strategies.
3 Determine the incremental cost-effectiveness ratio of the different implementation strategies in terms of expenditure per unit of patient care improvement achieved by the implementation strategy to each other and the control group with no incremental costs related to particular control group strategy.
4 Explore key informants perceptions of and experiences with the different intervention strategies.
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Uganda |
2018-03-06 |
2021-03-06 |
Medical and Health Sciences |
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Non-degree Award |
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David Coppock Layne
ID:
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Climate Change Perceptions and Adaptation Among Small-Scale Farmers in Uganda: A Community-Based Approach
REFNo: SS44ES
\r\n 1.) Determine if small-scale farmers in Uganda perceive the climate to be changing, and if so, determine how and why they perceive it to be changing.\r\n\r\n 2.) Determine what adaptive actions, if any, small-scale farmers in Uganda are taking in response to the changes in the climate they perceive.\r\n\r\n 3.) Determine what resources small-scale farmers in Uganda need to enhance their resilience to climate change. \r\n\r\n 4.) Determine how the climate-change perceptions, adaptive actions, and resource needs vary with the location where small-scale Ugandan farmers reside, particularly between urban and rural locales. \r\n
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USA |
2017-04-20 |
2020-04-20 |
Social Science and Humanities |
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Degree Award |
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Sarah O'Sullivan
ID:
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Undisclosed Stigma: the Politics of the Ordinary, ARV Adherence, and Development in Post-Conflict Northern Uganda
REFNo: SS47ES
(1) to understand how the history of war and aid-dependency in northern Uganda, along with the recent introduction of accessible anti-retroviral medication for people living with HIV contributions to ongoing stigma towards with living with HIV. (2) To provide a close qualitative analysis of how stigma associated with HIV post-ARV rollout affects HIV-positive people and their families. (3) to understand how severe aid-dependency and the proliferation of development initiatives in northern Uganda influences the expectations towards how people living with HIV on ARVs should behave as productive citizens contributing to northern Uganda’s post-conflict restructuring.
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Canada |
2016-12-13 |
2019-12-13 |
Social Science and Humanities |
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Degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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An Evaluation of the Association of Anaesthetists of Great Britain & Ireland Uganda Fellowship Programme.
REFNo: HS27ES
The research objectives are:\r\n\r\n1. To quantify the number of trained physician anaesthetists now working in Uganda, including their roles and responsibilities.\r\n\r\n2. To explore what impact the AAGBI Uganda Fellowship Programme has had on the standards of training in anaesthesia and patient care in Uganda.\r\n\r\n3. To explore how perceptions of the specialty of anaesthesia in Uganda have changed over the duration of the AAGBI Uganda Fellowship Programme.\r\n\r\n4. To understand the impact that different partnerships have had on the specialty of anaesthesia in Uganda over the last 10 years.\r\n
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UK |
2016-12-13 |
2019-12-13 |
Medical and Health Sciences |
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Non-degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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A cluster randomised trial to determine whether increased postoperative surveillance of adult African surgical patients reduces postoperative mortality
REFNo: HS298ES
Primary objective - To determine whether increased postoperative surveillance reduces in-hospital mortality in high-risk adult surgical patients aged 18 years and over in Africa.
Primary outcome measure - In-hospital mortality, censored at 30 days if the patient is still alive and in-hospital.
Secondary objective - To determine whether increased postoperative surveillance reduces the incidence of the composite of severe in-hospital complications and mortality in high-risk adult surgical patients aged 18 years and over in Africa.
Secondary outcome measure - Composite of severe in-hospital complications and mortality, censored at 30 days if the patient is still alive and in-hospital.
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UK |
2019-04-16 |
2022-04-16 |
Medical and Health Sciences |
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Non-degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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Family SuppleMented pAtient monitoRing afTEr suRgery (SMARTER) pilot trial
REFNo: HS944ES
To develop a training and support intervention, in accordance with the MRC complex intervention framework, to train family carers to perform and document basic vital signs, to supplement routine monitoring of patients by nursing staff, whilst they provide personal care to their relatives after surgery and to evaluate the effect of this intervention on frequency of documented vital signs for patients in the first three days after surgery in a stepped-wedge cluster trial.
To evaluate compliance with the trial intervention, and how this changes over the duration of the trial.
To evaluate the effect of the intervention on in-patient mortality, to inform the design of a subsequent international clinical trial across Africa
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UK |
2021-03-23 |
2024-03-23 |
Medical and Health Sciences |
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Degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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African Surgical Outcomes Study in Paediatric patients (ASOS-Paeds)
REFNo: HS2179ES
In paediatric surgical patients < 18 years in Africa: To determine the association between pre-operative, intra-operative and facility factors with postoperative complications and death. ,In paediatric surgical patients < 18 years in Africa: To determine the incidence of intraoperative severe critical incidents,,In paediatric surgical patients < 18 years in Africa: To determine the in-hospital postoperative mortality rate up to 30 days post-surgery,,To determine the incidence of in-hospital postoperative complications up to 30 days post-surgery in paediatric surgical patients <18 years in Africa,
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UK |
2022-05-27 18:55:24 |
2025-05-27 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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The African Critical Illness Outcomes Study
REFNo: HS3338ES
To determine the availability of resources for essential emergency and critical in African hospitals.,To investigate the association between the provision of essential emergency and critical care to critically ill patients and mortality.,To estimate the proportion of critically ill patients who receive essential emergency and critical care.,To establish the mortality rate of the critically ill patients and those who are not critically ill.,To establish the proportion of adult (18 years or older) inpatients in African hospitals that are critically ill.,
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UK |
2023-10-30 21:08:01 |
2026-10-30 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study.
REFNo: HS5389ES
To evaluate the impact of a structured antimicrobial review on rates of antimicrobial density, redundancy and associated indicators of antimicrobial utilisation.,To determine whether a structured antimicrobial review can be implemented in LMIC ICUs,
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UK |
2025-01-31 7:20:18 |
2028-01-31 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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‘5 Rs to Rescue’ A quality improvement initiative with a cluster trial evaluation and embedded process evaluation
REFNo: HS5020ES
To evaluate the effect of the QI intervention on: 1. 30 day in-hospital mortality. 2. Duration of hospital stay.,To evaluate whether implementation of the ‘5 Rs to Rescue’ quality improvement intervention increases surveillance for patients at risk of ‘failure to rescue’ after surgery in hospitals in Africa.,
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UK |
2025-01-22 12:30:25 |
2028-01-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Adam Hewitt Smith
ID: UNCST-2019-R001658
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Assessing the bottlenecks for coverage of Essential Emergency and Critical Care in Uganda, Tanzania, Ethiopia, and South Africa
REFNo: HS6924ES
To determine the underlying causes and suggested solutions of these bottlenecks.,To determine the implementation bottlenecks for the provision of EECC in public hospitals in Uganda, Tanzania, Ethiopia and South Africa ,To investigate the bottlenecks, and their underlying determinants, for the provision of EECC in hospitals in Uganda, Tanzania, Ethiopia and South Africa,
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UK |
2026-01-19 13:39:06 |
2029-01-19 |
Medical and Health Sciences |
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Non-degree Award |
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