Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Fred Brany Lukwago
ID:
Risk assessment of aflatoxins along the dairy value chain in Uganda
REFNo: A9ES

Overall Objective\r\nTo determine the factors associated with aflatoxins contamination, their economic impact along the dairy value chains and estimate the levels of risk exposure of humans to aflatoxins.\r\nSpecific Objectives \r\nThe specific objectives of this work are to:\r\ni. Determine the levels and occurrence of aflatoxins in selected foods, animal feeds, milk and milk products\r\nii. To establish the levels of human exposure and assess the risks associated with consumption of aflatoxins contaminated milk and milk products in Uganda \r\niii. Estimating the postharvest losses due to aflatoxins contamination along the dairy value chains\r\n
Uganda 2016-10-26 2019-10-26 Agricultural Sciences Degree Award
Sylvia Kusemererwa
ID: UNCST-2019-R001717
A phase III, multi-center, randomized, placebo-controlled, double-blind study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without hydroxyurea/hydroxycarbamide therapy, in adolescent and adult Sickle Cell Disease patients with frequent vaso-occlusive crises
REFNo: HS5607ES

To assess the efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without
hydroxyurea (HU)/hydroxycarbamide (HC) , on VOC rate in Sickle Cell Disease (SCD) patients aged 12 years and older who experience frequent vaso-occlusive crises (VOCs)
Primary Objective
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of VOCs* that are HCP managed (including VOCs leading to management at a health care facility or those via remote consultation) over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in 12 months prior to the screening visit).
Secondary Objectives
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without
hydroxyurea/hydroxycarbamide, on the annualized rate of all VOCs including VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) and VOCs that are self-managed without recommendations from HCP during the event over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in the 12 months prior to the screening visit).
2. To evaluate the annualized rate of VOCs by type of management between treatment arms over the planned 52-week treatment period:
 VOCs that are HCP-managed at a health care facility
 VOCs that are HCP-managed via remote consultation
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 VOCs that are self-managed without recommendations from HCP during the event
 VOCs that are HCP-managed via remote consultation or self-managed without recommendations from HCP during the event
Uganda 2025-04-02 8:58:47 2028-04-02 Medical and Health Sciences Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
A PILOT STUDY TO ASSESS THE ACCEPTABILITY AND PERFORMANCE OF THE MATERNAL PPH WRAP DEVICE FOR CONTROLLING POST-PARTUM HAEMORRHAGE
REFNo: HS499ES

1. To evaluate the acceptability and usability of the Maternal PPH Wrap among health women who are not at risk of PPH

2. To evaluate the preliminary performance of the Maternal PPH Wrap on women with mild postpartum haemorrhage
Uganda 2020-01-13 2023-01-13 Medical and Health Sciences Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Impacts of Covid-19 on Provision of Essential Healthcare Services and on Community Networks in Uganda
REFNo: HS2181ES

General Objective
To evaluate the Impact of COVID-19 on provision of essential Healthcare services and on the community networks in Uganda
Specific objectives
1. To determine the Impact of COVID-19 on essential health service delivery in Regional Referral Hospitals in Uganda.
2. To evaluate the actual local activities and collaboration of key stakeholders involved in CES in response to COVID-19 pandemic Uganda.


Uganda 2022-04-07 2025-04-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Mobile Phone enabled Diagnostics for Infectious Disease Diagnosis: Low Cost Tools for Digital Health in Uganda
REFNo: SIR50ES

I. Understanding Digital Health for Infectious Disease in Low Resource Settings
II. Understanding Data Integrity and Security in Digital Health in Africa;
III. Exploring the Relationship between Data and Healthcare Policy;
IV. ICT Devices for Data Acquisition and Communication in East Africa with a focus on Uganda;
V. Capacity Strengthening - Educational Training underpinning Mobile Health.

Uganda 2021-02-18 2024-02-18 Engineering and Technology Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Laparoscopic Cases Database
REFNo: HS1909ES

The second aim of the study is to use this data in a future project examining new low-cost laparoscopic equipment. ,The first aim of the study is to compare laparoscopic practices in several countries. ,This study aims to examine current laparoscopic practices in Uganda and the United States.,
Uganda 2021-12-02 2024-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Capacity building for a Centre of Design, Innovation and Translational Excellence (CITE) for clinical trials of healthcare technologies in SS Africa
REFNo: SS1181ES

To determine the current standards and policies governing the clinical trials and regulation of IMDs in Uganda,To determine the challenges and opportunities in clinical trials of IMDs in Uganda,To determine the requirements and stages for clinical trials of IMDs in Uganda,To map existing knowledge about the systems and processes for clinical evaluation of locally made Investigational medical Devices (IMD) amongst key stakeholders in Uganda,
Uganda 2022-02-08 2025-02-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Strengthening Interdisciplinary Research in Technology Translational Pathways for Improved Maternal and Child Health in Uganda
REFNo: HS2056ES

The general objective of the study is to strengthen interdisciplinary research in Technology translational pathways for improved maternal and child health in Uganda,To build a network of researchers including social scientists, data scientists, health services researchers, business researchers and implementational scientists in order to improve innovations and use of appropriate medical technologies for maternal and child health for use in Uganda.,To determine the number of med-Tech innovations that have managed to translate into marketable products in Uganda.,To determine the organizations and requirements involved in Medical Technology translation in Uganda. ,To Map current research/researchers, approaches, and bottlenecks in medical devices translation in Uganda and the UK. ,
Uganda 2022-02-08 2025-02-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
IMPACTS OF ENTEBBE HOSPITAL CLOSURE ON THE CLIENTS’ HEALTH STATUS DURING THE COVID-19 PANDEMIC IN UGANDA
REFNo: SS1425ES

2. To determine the extent of impacts on the health status of the previously registered clients of Entebbe RRH.,1. To understand the options used by patients to cope-up with access to necessary health services during the closure of Entebbe RRH.,To determine the impacts of Entebbe Regional Referral Hospital (ERRH) general services closure during the COVID-19 pandemic (March 2020 – April 2022) on registered and non-registered OPD clients in the Entebbe catchment area Uganda.,
Uganda 2022-09-12 18:13:58 2025-09-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Promoting Universal Health Coverage for Amputees in Uganda through Social Enterprise and Engineering Innovation
REFNo: SIR192ES

The principles of patient autonomy, non-maleficence, beneficence, and justice will be employed. Institutional safeguards, such as human subjects review committees and policies governing organisational ethics, will be followed. To this end, we shall seek ethical approval from the Makerere University School of Biomedical Sciences Research Ethics Committee and the Uganda National Council for Science and Technology. We shall also seek permission from the Ministry of Health as well as the management of the health units from which the data will be collected. We will provide verbal and written explanations of the study, including the aim, the level of participation required, potential risks of involvement, and the approximate duration of participation. The consent will include full verbal (in case of illiteracy) and written/signed informed consent from all individuals and groups before accepting to be interviewed. We will seek written permission to record interviews, and access meeting minutes, reports, and other relevant documents from relevant persons prior to including them in the research. Participants will be asked to give verbal consent and confirm this by reading and signing the consent form (included in the appendix). The key informants, including service users, will be free to withdraw consent at any time without giving an explanation and without this negatively affecting the care they receive. Data collectors will translate information into the relevant local language where required. We will seek verbal consent from participants who struggle to read and write, and the next of kin will sign the consent form on behalf of the user. We will only include participants 18 years of age and older who can provide consent on their own. The participant information sheet will explicitly state that participation in this study is purely voluntary. Participants can withdraw at any time, up to 14 days after data collection, without giving the reason for their withdrawal from the study. Their decision to withdraw from the study will not affect the services they receive. Participants will have up to 48 hours after receiving full details about the study, to consider participating in the research and ask questions.
Uganda 2023-02-22 8:38:27 2026-02-22 Engineering and Technology Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Affordances of makerspaces influencing biomedical undergraduate engineering students' design learning and curriculum localization in Uganda and the USA
REFNo: SIR448ES

Main Objective
To explore and compare how the affordances of the DesignCube makerspaces at Makerere University and Duke University influence biomedical engineering students' design learning and the localization of curriculum by the end of the study period.

Specific Objectives
1.To determine the perceived affordances of the DesignCube makerspaces among undergraduate biomedical engineering students at Makerere University and Duke University within the first four weeks of their engagement in the design coursework.

2.To assess the actual affordances of the DesignCube maker spaces after students’ full engagement with the prototyping and design coursework by the end of the academic term.

3.To identify the factors that foster or limit student engagement with the DesignCube makerspaces at Makerere University and Duke University by the completion of the study.

4.To evaluate how the affordances identified in each context (Makerere and Duke) inform the localization and adaptation of curriculum and pedagogy for design learning in biomedical engineering by the final stage of the study.
Uganda 2024-12-02 17:04:31 2027-12-02 Engineering and Technology Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
A Feasibility and Safety Study of the KeySuite Laparoscopic Devices for Cancer Diagnosis in Uganda
REFNo: SIR493ES

1. To evaluate potential safety issues associated with the use of the KeyScope in patients with intra-abdominal cancers or suspected cancers .
2. To determine the clinical performance of the KeyScope in viewing tissue masses in the abdomen.
3. To determine the clinical performance of the KeyLoop in retraction of the abdominal wall during laparoscopic surgery
4. To determine the acceptability of KeySuite laparoscopic devices in aiding to obtain laparoscopic biopsies

Uganda 2025-09-26 17:12:49 2028-09-26 Engineering and Technology Clinical Trial Non-degree Award
Eric Kreutter
ID:
Leadership Emergence: The Moderating Role of Self-Awareness
REFNo: SS32ES

This is a quantitative survey-based study. The proposed study seeks to address questions relating to the mediating roles of Self-Awareness in the process of Leadership Emergence in a small group.
USA 2016-10-31 2019-10-31 Social Science and Humanities Degree Award
Elaine Hsiao
ID:
Protecting Place, People and Peace: A Critical Socio-Legal Review of Transboundary Parks
REFNo: SS35ES

The purpose of this research is to assess the peace outcomes of transboundary conservation areas and ways that peace is captured in legal frameworks. This includes field research in three transboundary conservation areas of Uganda to provide qualititative and socio-political context for findings identified in the legal assessment. The three field sites are: (1) Greater Virunga Transboundary Collaboration, (2) Landscapes for Peace and (3) Mount Elgon.
USA 2016-11-29 2019-11-29 Social Science and Humanities Degree Award
Mahlet Woldetsadik Atakilt
ID:
Beyond the Survivor: The Impact of Conflict-Related Sexual Violence on Families of Women Survivors in Northern Uganda
REFNo: SS36ES

The objective of this research project is to assess Ugandan women’s experiences of conflict-related sexual violence (CRSV), explore how CRSV experiences affect family members, and evaluate current response programs to survivors. The overall goal is to provide evidence that can inform better response programming to CRSV survivors, and their family members. This project will address the following aims and research questions (R):\r\nAMI 1: Gain a better understanding of the experiences of CRSV survivors and families of survivors \r\nFrom the perspective of CRSV survivors\r\nR1a. How has the experience of CRSV affected the physical, psychological, and social well-being of women survivors living in post-conflict regions of northern Uganda?\r\no R1b. How do women survivors in northern Uganda think their CRSV experience has affected their relationship with their family?\r\no R1c. What kind of support, including response services, do survivors in northern Uganda seek or/and find the most helpful? \r\nFrom the perspective of families of CRSV survivors \r\no R1d. How do family members of CRSV survivors in northern Uganda think the experience has affected their relationship with the survivor? \r\no R1e. How has the presence of a CRSV survivor in the family affected the internal dynamics of the household? \r\no R1f. What kind of support or services related to CRSV experience did family members seek (if any) or would have liked to access?\r\nAIM 2 Estimate the costs of programs and their potential impact\r\no R2a. What are the main types of health services that organizations provide? \r\no R2b. What are the types of outcome measures are used by organizations that provide health services to survivors of CRSV in northern Uganda? \r\no R2c. How do programs measure effectiveness? \r\no R2d. Which programs or interventions are cost-effective, and what are their characteristics? \r\n
Ethiopia 2016-10-26 2019-10-26 Social Science and Humanities Degree Award
Esther Atukunda Cathyln
ID: UNCST-2019-R001701
SHINE - Exploring Intersectional Stigmas Among Men Living with HIV in Uganda
REFNo: HS1964ES

The primary objective in this study is to explore experiences of intersectional stigma among MWH and their partners who have unmet reproductive goals.
Uganda 2022-01-17 2025-01-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Esther Atukunda Cathyln
ID: UNCST-2019-R001701
Integration of a patient-centered mobile health intervention (Support-Moms) into routine antenatal care to improve maternal health in Uganda.
REFNo: HS3366ES

Evaluate the cost and cost-effectiveness of implementing Support-Moms intervention into routine care and implications for sustainability,Evaluate intervention implementation using the Proctor framework and plan for future scale-up per the Consolidated Framework for Implementation Research ,Test the effectiveness of the Support-Moms intervention in a randomized controlled trial,
Uganda 2023-11-13 12:57:49 2026-11-13 Medical and Health Sciences Clinical Trial Non-degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
Pooled screening of SARS-CoV-2 in the surrounding communities of Makerere University as a cost-effective strategy for reopening.
REFNo: HS912ES

General Objective
To assess the prevalence of SARS-CoV-2 and practices towards its prevention in the surrounding communities of Makerere University and the cost-effectiveness of pooled screening testing strategy to inform reopening of Makerere University.

Specific aims
1.To assess Knowledge, attitudes and practices of people living in areas surrounding Makerere University towards SARS CoV-2 prevention

2.Rapid assessment of high-risk populations around Makerere University for SARS CoV 2 by multi sample pool COVID-19 qRT-PCR technique

Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
REPRODUCTIVE TRACT INFECTIONS AMONGST STUDENTS: ADDRESSING THE CHALLENGE AT MAKERERE UNIVERSITY
REFNo: HS1810ES

To determine the prevalence of RTIs among Makerere University students,To assess the Reproductive Tract Infections (RTIs) related knowledge, attitude and practices (KAP) of the Makerere University population.,To address the challenge of Reproductive Tract Infections amongst students by establishing the prevalence, knowledge of students towards RTIs and reducing the gap through use of youth friendly approaches.,
Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
Observational study on management of post-partum haemorrhage at Kawempe National Referral Hospital (REBOA-PPH baseline study)
REFNo: HS2730ES

To suggest a customized training to improve PPH management in a large referral hospital in Uganda,To identify specific areas of potential improvements in PPH management,To describe the actions taken in the process of managing PPH among mothers admitted to KNRH,To describe the current management of severe PPH with timelines from identification until bleeding is controlled,To map the occurrence of severe PPH among birthing mothers admitted at Kawempe National Referral Hospital (KNRH),The aim of this study is to map the occurrence of severe post-partum haemorrhage (PPH) and its current management and to identify potential improvements in the management of severe PPH in a large referral hospital in Uganda. ,
Uganda 2023-03-09 23:43:20 2026-03-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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