Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
REBECCA NANTANDA
ID: UNCST-2019-R001533
Understanding the Strategies, policies and stakeholders perspectives on air quality management: towards improving air quality pollution in urban settings in Uganda.
REFNo: HS2097ES

To conduct a scoping review to synthesize air quality management strategies in Africa with a focus on who is involved, what works and why.

To assess the knowledge and perspectives of stakeholders whose roles influence air pollution and related health outcomes in Kampala and Jinja Cities.
Uganda 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Identifying implementation strategies for ALRITE, a mobile health tool to guide management of acute respiratory illnesses in young children.
REFNo: HS2789ES

Broad Objective: To generate, describe and prioritize barriers and facilitators to ALRITE implementation, and potential implementation strategies through an active participatory process involving Ugandan healthcare providers and key healthcare administrators


Specific objectives
1. To generate a broad list and description of barriers and facilitators to ALRITE implementation.
2. To generate and refine a list of implementation strategies tailored to Ugandan primary care health centers.
Uganda 2023-06-06 7:56:12 2026-06-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Assessment of feasibility, acceptability, hesitancy, safety, effectiveness and immunogenicity of COVID-19 vaccines among children in Uganda
REFNo: HS2910ES

1. To assess the feasibility and acceptability of COVID-19 vaccination of children in Uganda.
2. a) To determine the prevalence of hesitancy to COVID-19 vaccination for children in
Uganda.
b) To describe the drivers of hesitancy for vaccination of children against COVID-19 in
Uganda.
3. To assess the safety of COVID-19 vaccines among children aged 12-17 years in Uganda.
4. To determine immunogenicity the BioNTecg/Pfizer of among children aged 12-17 years in Uganda.
5. To determine the effectiveness of COVID-19 vaccines among children aged 12-17 years in Uganda.

Uganda 2023-08-18 9:40:38 2026-08-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
CHRONIC RESPIRATORY DISEASE OBSERVATORY FOR AFRICA (CHEST-AFRICA) UGANDA SITE SPECIFIC PROTOCOL
REFNo: HS3371ES

4. To assess the cost of care for asthma and COPD in Uganda,3. To assess the availability and affordability of diagnostic facilities and medicines for the management of asthma and COPD.,2. To describe the burden of symptoms, frequency and severity of exacerbations, emergency visits, and hospitalization for asthma in children aged 6-7 years in Uganda.,1. To determine the prevalence of asthma among children aged 6-7 years in Uganda.,
Uganda 2023-12-21 21:41:47 2026-12-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Improving access to Asthma Care among Children and Adolescents in Uganda
REFNo: HS4136ES

To assess the feasibility, acceptability, and effectiveness of routine screening for asthma symptoms, healthcare worker needs-directed training and mentorship and asthma education in improving diagnosis and management of children and adolescents with asthma in Uganda. Specific objectives The study is divided into 4 sub-studies, and each of them has specific objectives as outlined below. Sub-study 1: Routine screening for asthma symptoms Objectives 1. To evaluate the clinical and cost-effectiveness of routine screening for asthma symptoms among children and adolescents with respiratory illnesses in identification of patients with undiagnosed asthma 2. To assess the feasibility and acceptability of routine screening for asthma symptoms among children and adolescents with respiratory illnesses. Sub-study 2: Healthcare workers’ needs-directed training and mentorship Objectives 1. To evaluate the clinical and cost-effectiveness of needs-directed healthcare workers’ training and mentorship in improving asthma outcomes in children and adolescents. 2. To assess the feasibility and acceptability of implementing a needs-directed healthcare workers’ training and mentorship intervention for improving asthma outcomes in children and adolescents. Sub-study 3: Community Health Worker-led asthma education Objectives 1. To assess the clinical and cost-effectiveness of community health worker-led asthma education in improving asthma outcomes among children and adolescents. 2. To assess the feasibility and acceptability of community health worker-led asthma education among children and adolescents, and their caregivers. Sub-study 4: Psychosocial challenges of asthma Objective 1. To explore the psychosocial challenges faced by children and adolescents with asthma, and their caregivers.
Uganda 2024-05-07 12:43:04 2027-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Optimization and testing of ALRITE, a clinical decision support tool for management of respiratory illnesses in young children in primary care health facilities in Uganda
REFNo: HS5721ES

To pilot test ALRITE in 4 Ugandan health facilities after an optimization phase of iterative testing and ALRITE improvement.

1. To optimize ALRITE for health worker use through multiple cycles of reversal single-case experiments29,30* with 6-8 health workers per cycle.
2. Pilot-test study feasibility and the effectiveness of the optimized ALRITE tool on the diagnosis and management of wheezing illness and pneumonia in young children using interrupted time series (ITS) design.
3. Assess outcomes of implementation following ALRITE deployment and determinants of successful adoption using a sequential quant-> QUAL mixed methods design.
Uganda 2025-04-09 16:40:46 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Doherty Catherine
ID:
The Role of Goods Distribution for Stability in Ethnically-divided countries. Uganda Case Study
REFNo: SS66ES

Contribute to the growing literature on public goods distribution which takes into account that not all goods and services are treated equally and that they have different properties. For example, it will build on the work of Kramon and Posner (2013) and Burgess et al (2015). The project will also contribute to literature which examines political stability in developing countries (Magaloni 2008; Blaydes 2011) by adding a component of ethnic diversity. The objective of the proposed interviews with local and national government, NGOs, and traditional leaders is to understand the distribution structure used to provide different types of goods/services/transfers to different parts of the country. The objective of the survey is to understand what people receive on the ground in different areas of the country, what types of goods and services they prefer, what different goods indicate to people about the government’s attitude towards them, and who they believe is responsible for providing the different goods and services they receive.
Ireland 2017-05-17 2020-05-17 Social Science and Humanities Degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
Adaptation and Evaluation of a Direct PCR Based Method for the Diagnosis of Bacteremia among Critically Ill Patients in Uganda
REFNo: HS51ES

4.2.1. To introduce and optimize a broad range qPCR test for diagnosis of bacteremia at the MUCHS molecular biology laboratory 4.2.2. To evaluate the performance of the broad range qPCR among patients at the Mulago ICU and UCI against blood culture 4.2.3. To estimate the prevalence of various etiologic agents of bacteremia among UCI and Mulago ICU patients with sepsis 4.2.4. To determine the antimicrobial susceptibility profiles of the bacterial strains responsible for bacteremia at the UCI and the Mulago ICU
Uganda 2017-04-25 2020-04-25 Medical and Health Sciences Non-degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
IDENTIFICATION OF VIRULENCE FACTORS, TRANSMISSION PATTERNS AND ANTIBIOTIC RESISTANCE MECHANISMS OF EAST AFRICAN Vibrio cholerae ISOLATES BY WHOLE GENOME SEQUENCING
REFNo: HS338ES

Aim: To obtain whole genome sequences (WGS) of Vibrio cholera O1 isolated in various parts of Uganda from 2014 to 2018 and use the data to determine the evolution, spread, antimicrobial resistance mechanisms and pathogenesis of the isolates

Specific objectives:
1. Determine patterns of spread of V.cholerae O1 in Uganda and within the East African region using WGS
2.Infer relatedness and evolution of strains of V.cholerae O1 isolated in Uganda and the East African region from WGS data
3.Identify any uniqueness in virulence genes or their expression among strains of V.cholerae isolated in Uganda and the East African region from WGS data
4.Identify genes of antimicrobial resistance and infer prevailing mechanisms of antimicrobial resistance among V. cholerae O1 isolated in Uganda

Uganda 2019-05-14 2022-05-14 Medical and Health Sciences Non-degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
Comparison of community and hospital Antibiotic use practices, Susceptibility and resisTance and determinants of care seeking among patients with Urinary Tract Infections (CAST-UTI)
REFNo: HS4458ES

6. Determine the outcome of infections.,5. Assess the treatment practices of healthcare workers for acute UTIs in CDROs and hospitals.,4. Examine the resistance profiles for differences between neighbourhoods (Namuwongo and Muyenga),3. Determine the appropriateness of treatment based on standard treatment guidelines for acute UTIs in the community (based on organism and resistance profile,2. Explore the social context of antibiotic prescribing and use in the community. ,1. Determine and compare the resistance profiles of the disease-causing organisms in community drug retail outlets (CDRO’s)/clinics, and in hospitals/ WHO-GLASS ,
Uganda 2024-09-23 13:14:32 2027-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
Low-interventional, multi-centre study of the burden of nosocomial infections among hospitalised patients in sub-Saharan Africa
REFNo: HS1880ES

Aim:
To assess antimicrobial resistance rates, as well as clinical outcomes (including treatment outcomes, mortality rate, hospital length of stay), healthcare resource utilisation (HCRU) and associated costs among hospitalised patients with nosocomial infections at Mulago Specialised Referral Hospital.

Study Objectives:
1. To estimate the prevalence of resistance in nosocomial infections(NI) amongst patients hospitalized at Mulago Specialized Referral Hospital
2. To describe treatment outcomes amongst hospitalized patients with NI, at the end of therapy and at hospital discharge
3. To assess mortality rates (all-cause & infection-related) of hospitalized patients with NI, at the end of therapy & at hospital discharge
4. To assess hospital length of stay amongst hospitalized patients with NI.

Secondary Study Objectives
1. To describe treatment outcomes amongst hospitalized patients with NI at Day 14/30 post-treatment initiation
2. To assess mortality rates (all-cause and infection-related) of hospitalized patients with NI, at Day 14/30 post-treatment initiation
3. To assess ICU length of stay amongst hospitalized patients with NI.
4. To describe the characteristics of hospitals participating in the study
5. To assess HCRU and associated costs post-hospitalization amongst hospitalized patients with NI
6. To assess the nursing care demand amongst hospitalized patients with NI

Uganda 2021-12-03 2024-12-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
Phenotypic and genotypic analysis of African Bacterial isolates
REFNo: HS6377ES

Objectives:

Main Objective
1. To characterise priority resistant bacteria and establish a repository of well characterised bacteria and bacterial genomes on the African continent that shall inform surveillance systems, research and development (R&D) of new antimicrobial therapeutics, vaccines, and diagnostics for addressing AMR in African populations.

Specific Objectives
1. To determine and compare mobilomes of selected pathogens implicated in blood stream and other infections in Uganda and other African countries
2. To determine and compare the resistome of selected pathogens implicated in blood stream and other infections in Uganda and other African countries
Uganda 2026-01-19 15:53:59 2029-01-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Holly Lyne
ID:
What are the current challenges face in continuing care of premature neonates, following discharge, in Eastern Uganda?
REFNo: HS52ES

1. To assess how carers of preterm neonates are prepared to continue providing all aspects of care for their baby following their discharge from the neonatal unit at the MRRH in Mbale. 2. To explore the attitudes of carers, as well as the perceived barriers and facilitators, to those caring for babies born
UK 2017-05-30 2020-05-30 Medical and Health Sciences Degree Award
John Simaika
ID:
Developing and testing methods for wetland health assessment using dragonflies
REFNo: NS10ES

A major objective of my study is to adapt biomonitoring tools for use on wetlands of Uganda. My project is planned for a two-year period to incorporate seasonal changes with a high degree of confidence. This work will close the knowledge gap on two more objectives to: (1) quantify the robustness of using dragonflies as indicators of wetland integrity in the region; and, How representative are the richness and species composition of the integrity of wetland ecosystems in comparison to wetland plants, a commonly used indicator? (2) quantify the performance of the ecological integrity indices. How representative are the ecological integrity indices of wetland health (e.g. correlation with Wet-Health)? How much effort is needed to use the dragonfly indices in the field? How much effort is needed to calculate and interpret the indices? Is this effort more or less than that needed for conventional methods (e.g. Wet-Health)?
Germany 2017-05-09 2020-05-09 Natural Sciences Non-degree Award
Kamoga Ronald
ID: UNCST-2019-R001524
VAGUS NERVE STIMULATION IN A RAT MODEL OF ALZHEIMER’S DISEASE-LIKE SYMPTOMS: MORPHOLOGICAL, IMMUNOHISTOCHEMICAL, MOLECULAR AND BEHAVIORAL CHANGES
REFNo: HS3781ES

1. To conduct a scoping review of literature on vagus nerve stimulation in Alzheimer's-disease and related dementias.
2. To determine behavioral changes associated with vagus nerve stimulation in a rat model of Alzheimer-like symptoms.
3. To evaluate the morphological, Immunohistochemical and molecular changes in the Hippocampus, prefrontal cortex and medial temporal cortex associated with chronic stimulation of the vagus nerve in a rat model of Alzheimer’s-like disease.

Uganda 2024-02-26 13:43:22 2027-02-26 Medical and Health Sciences Clinical Trial Degree Award
Kamoga Ronald
ID: UNCST-2019-R001524
ASSESSMENT OF ADHERENCE TO A MEDITERREANAN DIET AND CHALLENGES ASSOCIATED WITH FEEDING PEOPLE HAVING MILD TO MODERATE DEMENTIA IN SOUTH WESTERN UGANDA.
REFNo: HS4404ES

To determine the barriers and facilitotors of adherence adherence to a mediterranean diet among people living with dementia and those at risk of dementia in southwesten Uganda,To determine the level of adherence to a Mediterranean diet among people with dementia and those at risk of dementia in southwestern Uganda,1) To determine the types of diet and dietary pattern of people with dementia and those at risk of dementia in southwestern Uganda,To assess types of diet, dietary patterns, adherence to mediterranean diet and associated factors in people living with mild to moderate dementia and those at risk of dementia in Southwestern Uganda ,
Uganda 2024-08-29 18:42:48 2027-08-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jeninah Atwebembeire
ID:
BIOLOGICAL AND PHYSICO-CHEMICAL PROFILE OF SURFACE WATERS DRAINING INTO RIVER RWIZI BASIN, SOUTH WESTERN UGANDA
REFNo: NS8ES

General objective To determine the biological and physicochemical status of surface waters draining into River Rwizi. Specific objectives i. To determine the sources associated with contamination of the river. ii. To determine the presence of indicator bacteria in streams, channels and sewage effluents draining into river Rwizi along seasonal gradient. iii. To determine the physical-chemical parameters in streams and channels, sewage effluents draining into river Rwizi along seasonal gradient. iv. To determine the impact of pollution on the water quality using macrozoobenthos indicators in the river and its streams, in the upstream, midstream and downstream, during seasonal variations in river Rwizi
Uganda 2017-08-28 2020-08-28 Natural Sciences Degree Award
BAPOLISI ACHILLE MWIRA
ID:
Post-traumatic stress disorder, psychiatric comorbidities and associated factors among refugees in Nakivale Camp in south Western Uganda.
REFNo: HS53ES

General objective • To asses psychiatric comorbidities with PTSD among refugees in Nakivale Camp. Specific Objectives •To determine the prevalence of PTSD, anxiety disorder, depression and substance use disorders among refugees in Nakivale Camp. •To determine the psychosocial stressors associated with PTSD, anxiety disorder, depression and substance use disorders among refugees. •To compare the prevalence of anxiety disorder, depression and substance use disorders among refugees with and without PTSD in Nakivale Camp.
Democratic Republic of Congo 2017-05-17 2020-05-17 Medical and Health Sciences Degree Award
wasswa william
ID: UNCST-2019-R001217
Automated Diagnosis and Classification of Cervical Cancer from Pap-Smear Images.
REFNo: HS129ES

The general objective of this research is to design and validate a robust automated tool for diagnosis and classification of cervical cancer using hybrid Segmentation and Classification techniques applied to Pap smear images. To achieve this objective and address the research problem, the following specific research objectives have been formulated. 1. To review state of art prominent recent publications focusing on the application of machine learning and medical imaging in automated detection and classification of Cervical Cancer from Pap-smear images. 2. To acquire Pap-smear images and develop a hybrid technique for automated segmentation and classification of cervical cancer. 3. To develop an interactive graphical user interface (GUI) platform to facilitate the automated diagnosis and classification of cervical cancer from Pap-smear images. 4. To test and validate the developed platform using patient results obtained from a manual screening of the Pap-smear images by a trained and experienced cytologist and also comparing the algorithms with results obtained by other researchers on the same open source datasets (Hervlet Cervical cancer dataset).
Uganda 2018-05-22 2021-05-22 Medical and Health Sciences Degree Award
Rene Dommain
ID:
Testing Historical Presence of Mountain Gorillas and Elephants in an African Biodiversity Hotspot using Targeted Enrichment of Sedimentary Ancient DNA
REFNo: NS13ES

Reconstructing the floristic and vegetation history of Bwindi Impenetrable Forest for the past ca. 30000 years. Determining the past presence and invasion history of mountain gorillas and elephants at Bwindi Forest. Determining the natural climatic and habitat conditions that enable gorilla survival and predict future gorilla distribution in Uganda.
Germany 2017-06-13 2020-06-13 Natural Sciences Non-degree Award
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