Agnes Kiragga
ID:
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Reproductive Health Empowerment through Telehealth
REFNo: HS425ES
1-With input from a Community Advisory Board develop a user-centered mobile-based reproductive health content targeted for men through SMS, interactive voice response.
2-Assess the feasibility and acceptability of the Men’s Telehealth Information Package (mTIP) on uptake of family planning and reproductive health services.
3-Assess the men’s knowledge and attitudes towards family planning following receipt of the Men’s Telehealth Information Package (mTIP)
4-Assess uptake of and attitudes towards FP and couple communication among women whose spouses received the Men’s Telehealth Information Package (mTIP) intervention.
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Uganda |
2019-08-06 |
2022-08-06 |
Medical and Health Sciences |
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Non-degree Award |
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Agnes Kiragga
ID:
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Community Pharmacies for Assessing STI Prevalence using Point of Care diagnostics study (COPHAS)
REFNo: HS1274ES
Aim 1: To estimate the prevalence of curable STIs and HIV among persons accessing health services at community pharmacies in Kampala and Wakiso Districts.
Aim 2: To determine the feasibility and uptake of pharmacy-based specimen collection and POC testing for curable STIs and HIV among persons seeking health care services at community pharmacies in Kampala and Wakiso Districts. Uptake will be measured among the three groups of persons i.e. Persons seeking EC (group 1), clients with STI symptoms (group 2) and persons without STI symptoms (group 3)
Secondary quantitative aims:
Aim 3: To determine treatment completion among persons diagnosed with an STI at the community pharmacies in Kampala and Wakiso Districts.
Aim 4: To determine linkage to care and ART initiation among newly diagnosed HIV positive persons at the community pharmacies in Kampala and Wakiso Districts.
Aim 5: To determine the baseline and 3-month knowledge about STI and STI treatment guidelines, and principles of antimicrobial stewardship of pharmacy staff. In addition, to assess the acceptability of POC STI diagnostics collocated with the pharmacy, to pharmacy owners and staff.
Qualitative aims
Aim 6: To assess the acceptability and client satisfaction of STI and HIV testing at community pharmacies in Kampala and Wakiso Districts.
Partner notification sub-study
Aim 7: To determine the effect of technology-supported partner notification and treatment initiation using Call for LifeTM technology among persons diagnosed with an STI or HIV at community pharmacies.
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Uganda |
2021-03-26 |
2024-03-26 |
Medical and Health Sciences |
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Non-degree Award |
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Agnes Kiragga
ID:
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Piloting a HIV Risk assessment application to increase awareness and uptake of HIV prevention services among young adults in Uganda. (SIDARISK)
REFNo: HS1293ES
• To assess the extent of high-risk sexual behavior and related practices among young adults using a web-based individualized HIV risk platform (SIDARISK)
• To establish the feasibility of using an existing telehealth platform for the referral and linkage to HIV/STI testing and prevention services following risk assessment by the SIDARISK application.
• To understand acceptability of the SIDARISK application for HIV risk assessment among young adults in Uganda
• To establish the feasibility of using a telehealth platform for provision of information on HIV risk reduction and linkage to HIV and PrEP services following using of the SIDARISK application
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Uganda |
2021-03-18 |
2024-03-18 |
Medical and Health Sciences |
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Non-degree Award |
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Agnes Kiragga
ID:
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SARS-CoV-2 international biorepository and diagnostic test performance
REFNo: HS1808ES
Primary:
• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing SARS-CoV-2 infection using frozen samples.
Secondary
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing SARS-CoV-2 infection
• To determine agreement between self-collected nasal swabs, saliva and clinician-collected nasopharyngeal swab samples for the diagnosis of SARS-CoV-2 using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected nasal swab tests and saliva for testing SARS-CoV-2 in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive SARS-CoV-2 diagnosis.
|
Uganda |
2022-05-13 7:45:44 |
2025-05-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
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An education package to improve health worker communication with women and families after stillbirth or neonatal death: A feasibility study
REFNo: HS1102ES
1. To pilot an education package and associated resources, including train the trainer/training manuals and audio-visual aids to improve health worker communication in Malawi, Uganda, Zambia and Zimbabwe.
2. For feasibility
a. Explore the acceptability and implementation of the package with facility staff receiving training, trainers and service managers across settings.
b. Explore the acceptability and implementation of the package with undergraduate midwifery students receiving training.
c. Assess uptake and attendance/completion of the package.
d. Explore impacts of the research and education package on practice and clinical services.
3. To prepare for a full-scale evaluation:
a. Define the most appropriate primary and secondary outcomes to assess the effect of the educational package on health workers’ communication and parents’ experiences.
b. Assess the acceptability and burden of data collection for participants.
c. Use data to optimise the design and estimate the sample size for a full-scale trial.
d. Exploration of key resources associated with implementing the educational package will be completed to provide an economic understanding of the intervention and its potential impact.
e. To utilise existing and develop additional networks to identify potential sites for a full-scale trial.
4. To combine the feasibility, acceptability and uptake data to develop a full trial protocol by the end of the study.
|
Uganda |
2021-04-21 |
2024-04-21 |
Medical and Health Sciences |
|
Non-degree Award |
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Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
|
Translation and validation of the Perinatal Grief Intensity Scale in Kenya and Uganda
REFNo: HS2296ES
1. To perform a culturally sensitive translation and adaptation of the Perinatal Grief Intensity Scale in Kiswahili and Luganda
2. To assess validity and reliability via face, content and construct validity and internal consistency
3. To obtain statistical estimates pertaining to the use of the tool
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Uganda |
2022-07-13 10:47:29 |
2025-07-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
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Development of a meta-core outcome set for stillbirth prevention and bereavement care following stillbirth
REFNo: HS2332ES
1) To identify a list of outcomes used in current stillbirth research together with outcomes reported in qualitative literature in an Low and Middle income Country (LMiC) setting relevant to stillbirth.
2) To prioritise outcomes from a health care professional, researcher and parent perspective from an LMic setting.
3) To integrate the outcomes important to all stakeholders in order to ratify a Core Outcome Set.
|
Uganda |
2022-08-25 12:09:48 |
2025-08-25 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
|
EVALUATING THE EFFECT OF A LOW-COST FOETAL HEART RATE MONITOR AND EDUCATIONAL PACKAGE ON MONITORING INTERVALS AND NEWBORN OUTCOMES IN GULU DISTRICT.
REFNo: HS2868ES
1. To assess the effect of a low-cost Foetal Heart Rate Monitoring device (Moyo) on the Foetal Heart Rate monitoring intervals.
2. To assess the effect of a low-cost FHRM device (Moyo) on detection of fetal heart rate abnormalities
3. To evaluate the effect of the intervention package on immediate newborn outcomes
4. To explore health care providers experiences of Foetal Heart Rate Monitoring before and after the intervention.
|
Uganda |
2023-07-06 17:16:36 |
2026-07-06 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
|
Development and testing of a tool to assess health workers' clinical confidence to provide perinatal bereavement care in Sub-Saharan Africa (MAKSHSREC-2024-703)
REFNo: HS4959ES
To assess the validity and reliability of the tool across health workers providing care to parents in maternity facilities, including internal consistency and factor structure,
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Uganda |
2024-10-21 15:14:14 |
2027-10-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
|
Evaluation of a multicomponent intervention to improve perinatal bereavement support for women and families after stillbirth and neonatal death in Kenya and Uganda: A pragmatic cluster randomised controlled trial.
REFNo: HS3205ES
To explore factors influencing future scale up and sustainability of the intervention ,To explore potential mechanisms of impact of the intervention through understanding womens’, families’, health workers’ and service managers’ views and experiences of the intervention and usual care after stillbirth and neonatal death,To evaluate whether the intervention was implemented as intended during the trial by assessing fidelity, ‘dose’, reach and adaptations made in the study context. ,To assess the cost effectiveness of the intervention from the perspective of the local health systems in Kenya and Uganda ,To assess the mediating effect of perceived social support on intervention impact. ,To assess the impact of the intervention on maternal anxiety, risk of depression and development, diagnosis, and treatment of mental health conditions.,To assess the effectiveness of the co-produced multicomponent interventions in reducing perinatal grief intensity at 8-12 weeks post birth for women who have experienced stillbirth or early neonatal death. ,
|
Uganda |
2024-01-24 23:23:30 |
2027-01-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
|
Experiences of the CEI members and Researchers working together during Global Health Research on Stillbirth Prevention and Bereavement Care: A grounded theory study in Sub-Saharan Africa and South Asia.
REFNo: SS4036ES
To produce an explanatory theory to underpin a working framework to support relevant research projects and programmes,To understand social processes that guide relationships between CEI members and researchers within a large global health programme,To understand researchers’ experiences of engaging with the CEI group within a large global health programme,To understand CEI group member experiences of contributing to research within a large global health programme,To gain better understanding of facilitators and barriers to effective community engagement through a grounded theory approach,
|
Uganda |
2025-08-18 13:51:30 |
2028-08-18 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Samson Okello
ID: UNCST-2019-R001580
|
Polycyclic aromatic hydrocarbon exposures and dietary risk of Esophageal squamous cell cancer in southwestern Uganda
REFNo: HS37ES
1) To evaluate biomass fuel exposure as an ESCC risk factor by comparing personal carbon monoxide exposure among ESCC patients to that of age and gender matched controls with normal esophageal epithelia. We hypothesize that individuals with ESCC have greater exposure to biomass fuel compared to matched age and gender controls. \r\n\r\n2) To assess food preparation methods and dietary patterns as risk factors for ESCC in southwestern Uganda. We hypothesize that patients with ESCC have unique food preparation methods and consumed foods with high polycyclic aromatic hydrocarbons content compared with age and gender-matched controls with normal esophageal epithelia.\r\n
|
Uganda |
2017-03-28 |
2020-03-28 |
Medical and Health Sciences |
|
Non-degree Award |
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Samson Okello
ID: UNCST-2019-R001580
|
Impact of HIV-infection on Geriatric Health among Older-Age People in Southwestern Uganda.
REFNo: HS97ES
Our main objective for this study is to provide data to help answer the following question:
How does the prevalence of and risk factors for frailty, decreased physical functioning, visual/auditory impairment, and neurocognitive disorders differ between HIV-infected people versus HIV-uninfected controls in Uganda.
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Uganda |
2017-11-08 |
2020-11-08 |
Medical and Health Sciences |
|
Non-degree Award |
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Samson Okello
ID: UNCST-2019-R001580
|
Epidemiology of Coronary Artery Disease among People with HIV in Rural sub-Saharan Africa
REFNo: HS267ES
Our over-arching goals are to demonstrate the extent to which coronary artery disease (CAD) burden may be greater among PLWH in rural Uganda, to discern which risk factors are responsible for this greater burden, and to propose a risk score and promising intervention targets to improve the health of this population.
Aim 1: Determine whether CAD is more prevalent and severe among PLWH than HIV-uninfected comparators in rural Uganda. We will complete coronary CT angiography in 600 participants and compare the prevalence and severity of CAD between PLWH and HIV uninfected comparators, before and after adjustment for traditional risk factors
Aim 2: Determine the extent to which the association between HIV infection and CAD is modified by sex and region. Within our cohort, we will test for effect modification by sex
Aim 3: Identify regional correlates of CAD, and develop a risk prediction score for the presence of CAD among PLWH in rural sub-Saharan Africa. We will collect data on traditional (e.g. age, smoking, diabetes), HIV-specific (e.g. macrophage activation, CD4 count, ART history), and region-specific factors (e.g. biomass exposure, K:T ratio, tuberculosis infection). In Aim 3a we will include traditional, HIV-specific and regional risk factors in models to identify correlates of CAD. In Aim 3b, we will propose a simplified risk score to identify PLWH with CAD.
|
Uganda |
2019-01-29 |
2022-01-29 |
Medical and Health Sciences |
|
Non-degree Award |
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Samson Okello
ID: UNCST-2019-R001580
|
Experiences and Perspectives of Patients with Hypertension in Mbarara, Uganda
REFNo: HS343ES
To understand the patient experience of hypertension, including diagnosis, understanding of disease, medical adherence, and treatment regimens.
|
Uganda |
2019-06-06 |
2022-06-06 |
Medical and Health Sciences |
|
Non-degree Award |
|
Samson Okello
ID: UNCST-2019-R001580
|
Cardiovascular risk factor profiles and outcomes in rural Uganda: The Bugoye Hypertension Improvement Project (B-HIP)
REFNo: HS487ES
1. To assess the baseline (at time of enrollment to BHIP) prevalence of various cardiovascular risk factors (obesity, dyslipidemia, and diabetes mellitus) in adults visiting the Bugoye Hypertension Improvement Project.
2. To determine incidence of sustained blood pressure control among persons with hypertension enrolled in BHIP.
3. To assess the costs of hypertension care in a Level III healthcare center in rural Uganda.
|
Uganda |
2020-02-07 |
2023-02-07 |
Medical and Health Sciences |
|
Non-degree Award |
|
Samson Okello
ID: UNCST-2019-R001580
|
Epidemiology of cardiac dysfunction in sub-Saharan Africa: Heart Failure Registry of HIV-infected and HIV-uninfected persons in Uganda and Zambia
REFNo: HS788ES
1. To describe the clinical characteristics, treatment outcomes, and predictors of all-cause and CV mortality among HIV-infected and HIV-uninfected heart failure adults hospitalized at Mbarara Regional Referral Hospital (Mbarara, Uganda) and University of Zambia Hospital (Lusaka, Zambia).
2. To describe echocardiographic etiology of heart failure among HIV-infected and uninfected adults hospitalized at Mbarara Regional Referral Hospital (Mbarara, Uganda) and University of Zambia Hospital (Lusaka, Zambia).
3. To determine the differences in the serum markers of cardiac fibrosis, cardiac injury, oxidative stress, and hypercoagulability in HIV-infected and HIV-uninfected individuals hospitalized with heart failure at Mbarara Regional Referral Hospital and the University of Zambia Hospital.
|
Uganda |
2022-03-30 |
2025-03-30 |
Medical and Health Sciences |
|
Non-degree Award |
|
Samson Okello
ID: UNCST-2019-R001580
|
EsophaCap for the Detection of Early Esophageal Carcinoma
REFNo: HS3248ES
Using our POC approach to carry out a diagnostic pilot study of ESCC in Uganda,In order to achieve fully automatic high-speed biomarker assaying, to design a small,light apparatus,In order to achieve a sample-to-answer assay, to implement DNA extraction, bisulfitetreatment, and methylation-specific PCR into a magnetofluidic chip with dried reagents.,Using a sponge-capsule swallowed/tethered collection device, to construct amethylation marker-based strategy to detect ESCC,To evaluate and validate the performance of the combined sponge methylation biomarker strategy in vivo in PRoBE-compliant, among prospective live cohorts od patients with EAC/HGD, ESCC and gastric cancer and controls in Uganda.,
|
Uganda |
2024-04-26 9:27:48 |
2027-04-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Joseph Ngonzi
ID: UNCST-2019-R001579
|
Automated visual evaluation and geospatial mapping for cervical cancer screening optimization in sub-Saharan Africa (AVE-Map)
REFNo: HS2069ES
3. To use AVE and geospatial analysis to scale up cervical cancer screening in Uganda ,2. To determine access to cervical cancer screening and referral pathways in Uganda ,1. To validate and expand use of AVE for cervical cancer screening in SSA ,We aim to leverage and develop data science expertise at our sites to first optimize and then combine AVE-based screening by health workers at peripheral health facilities with geospatial-analysis and needs-driven assessment to inform scale-up of cervical cancer screening in Uganda ,
|
Uganda |
2022-02-28 |
2025-02-28 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Joseph Ngonzi
ID: UNCST-2019-R001579
|
Smart Discharges for Mom & Baby: A cohort study to develop prognostic algorithms for post-discharge readmission and mortality among mother-infant dyads..
REFNo: HS2174ES
To identify gaps and opportunities during in-hospital, discharge, and post-discharge care to inform the future development of an evidence-and risk-based bundle of interventions to improve postnatal care (PNC) for dyads.,To inform the development of an integrated maternal and newborn risk-based post-discharge care program.,To develop and internally validate clinical risk prediction models for identifying dyads at high-risk of death or hospital readmission in the 6 week post-delivery post-discharge period.,
|
Uganda |
2022-04-07 |
2025-04-07 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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