Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Andrew Kambugu
ID: UNCST-2019-R000823
 Evaluation of the Impact of the Epidemic Ready Primary Health Care Project on Outbreak Preparedness and Response in Primary Healthcare Facilities in Uganda.
REFNo: HS6147ES

To document challenges, best practices, and lessons learned during project implementation,To assess the rollout and the associated change in knowledge of healthcare workers trained using the clinical IDSR (cIDSR)digital training platform. ,To assess health facilities’ epidemic readiness using simulated patient exercises.,To assess the impact of the ERPHC longitudinal health worker capacity building mentorship on epidemic readiness: Surveillance, Infection Prevention and Control, and Case Management.,To evaluate the impact of the Epidemic Ready Primary Health Care project on outbreak preparedness and response in primary healthcare facilities in Uganda. ,
 Uganda 2025-10-16 9:09:31 2028-10-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gilbert Akampurira
ID: UNCST-2024-R003558
 PREVALENCE AND FACTORS ASSOCIATED WITH EPISIOTOMY EXTENSION INTO THIRD- OR FOURTH-DEGREE PERINEAL TEARS AMONG WOMEN DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5072ES

1. To determine the prevalence of episiotomy extension into third or fourth-degree perineal tears among women delivering at Mbarara Regional Referral Hospital.
2. To determine the factors associated with episiotomy extension into third or fourth-degree perineal tears among women delivering at Mbarara Regional Referral Hospital.

Uganda 2024-10-08 17:49:03 2027-10-08 Medical and Health Sciences Non-Clinical Trial Degree Award
Akampurira Paul
ID:
TOWARDS ENSEMBLE CLASSIFICATION ALGORITHMS FOR DIAGNOSIS OF BREAST CANCER IN WOMEN: A COMPARATIVE APPROACH
REFNo: SIR64ES

General objective
To design an ensemble model from heterogeneous base learners for detecting breast cancer to reduce the error rate on diagnosis, reduce the time taken to reach a diagnosis and also accurately predict a future risk of the disease.


Specific objectives
1. To establish requirements for designing machine learning model for diagnosing breast cancer in women with abnormal breast masses.
2. To design classification models for diagnosing breast cancer in women with abnormal breast masses.
3. To Evaluate the performance of the designed models and establish a better model for diagnosing breast cancer in women with abnormal breast masses.
4. To develop an ensemble model from the evaluated classification algorithms for breast cancer diagnosis in women.



 Uganda 2022-01-12 2025-01-12 Engineering and Technology Non-Clinical Trial Degree Award
Sarah Akampurira
ID: UNCST-2025-R019367
 Stakeholder Engagement, Entrepreneurship Education, and Entrepreneurial Intention among Business Graduates of Chartered Universities in Southwestern Uganda
REFNo: SS4425ES

1. To determine the relationship between stakeholder engagement and entrepreneurial intention among university business graduates. 2. To assess the relationship between stakeholder engagement and entrepreneurship education among university business graduates. 3. To evaluate the relationship between entrepreneurship education and the entrepreneurial intention of university business graduates. 4. To analyse the mediating role of entrepreneurship education on the relationship between stakeholder engagement and entrepreneurial intention among university business graduates.
Uganda 2025-12-01 20:37:44 2028-12-01 Social Science and Humanities Non-Clinical Trial Degree Award
Janet Lewis I
ID:
Reducing Prejudice Against Refugees Pilot
REFNo: SS662ES

The vast majority (85%) of the world’s political refugees live in developing countries, according to UNHCR. As of early 2019, Uganda was home to over one million refugees from South Sudan, and had the largest refugee/asylum-seeker population in Africa (ACCORD 2019). Uganda has a strong national commitment to hosting refugees that is reflected in its immigration policies, leading some to call it a “melting pot” of regional nationalities. Still, its population faces challenges absorbing these refugees that are common to host countries. Relations are often strained between the refugee population and Ugandans, some of who perceive refugees as unwelcome competition for local resources and services (World Vision 2018; UNHCR 2018; ACCORD 2019).
This study will allow us to better understand the perceptions of Ugandans towards South Sudanese refugees, and measure both the extent of anti-refugee prejudice there and whether a perspective-taking intervention is effective at reducing prejudice. This knowledge will be crucial for understanding how best to design a later, larger study, which could substantially advance knowledge about prejudice reduction towards refugees in Uganda.
Furthermore, this study will provide a useful indication about whether our full version of this study will be able to measure spillover of the treatment through social networks; we will ask respondents in our endline survey about whether and with whom respondents discussed the intervention. Prejudicial attitudes are socially reinforced; changing one person’s mind may be difficult if that person’s peers still hold prejudicial beliefs. Likewise, if many of one’s peers have begun to reconsider their own prejudices, one may be encouraged to do so as well. Our prior work leads us to expect the information to spread widely, and some change in attitudes and behavior, but only for those connected to a treatment recipient via certain kinds of social ties (Larson and Lewis 2017, 2018). Practitioners often assume that interventions spread from a subset of individuals to their broader community through felicitous spillovers. If this pilot is successful, our full study will be among the first to measure whether and how this occurs for prejudice reduction through networks. This knowledge could, among other things, lead to more efficient designs of community prejudice-reduction projects. Moreover, even if spillover effects are not present, the full study will be able to detect how news of the intervention spreads through local networks. Doing so will provide rare, direct evidence of information dissemination through word-of-mouth networks, which is useful for the design of programs aimed at seeding any type of public service message – from news intended to diffuse conflicts, to information about a new technology that promises to better hold politicians accountable or improve public health.

Our pilot study therefore addresses four questions:
(1) What is the extent of anti-refugee prejudice among Ugandans living in villages in West Nile?
(2) Do positions towards refugees correlate with their positions in village social networks?
(3) Can a brief conversation oriented towards taking the perspective of South Sudanese refugees reduce Ugandans’ prejudice toward them? If so, does the effect persist after 2-3 weeks?
(4) To what extent does news spread about this perspective-taking exercise, and through which types of contacts?
 USA 2021-02-12 2024-02-12 Social Science and Humanities Non-degree Award
Mildred  AKANDINDA
ID: UNCST-2023-R005963
 FACTORS AFFECTING TURNAROUND TIME OF POSTGRADUATE RESEARCH ETHICS APPROVAL AND THE PERCEPTIONS OF GRADUATE STUDENTS ON THE REVIEW PROCESS IN SOUTHWESTERN UGANDA
REFNo: SS3996ES

To determine the turnaround time of research ethics approval of postgraduate research proposals at MUST and KIU-WC.
ii. To explore the factors affecting the turnaround time of research ethics approval of postgraduate research proposals at MUST and KIU-WC.
iii. To assess the perceptions that postgraduate students have on the research ethics approval process at MUST and KIU-WC.

Uganda 2025-07-10 18:50:06 2028-07-10 Social Science and Humanities Non-Clinical Trial Degree Award
John Gad Akankwasa Tibesigwa
ID: UNCST-2023-R005985
 A CHRISTIAN APOLOGETIC RESPONSE TO RELIGION REVISIONISM IN UGANDA: A CASE OF THE FAITH OF UNITY RELIGION IN BUNYORO SUB-REGION
REFNo: SS2210ES

3. To examine how Christian apologetics could be used to address the effects religious revisionism by the Faith of Unity religion in Bunyoro sub-region,2. To explore how religion revisionism by Faith of Unity religion is affecting Church ministry in Bunyoro sub-region,1. To Analyse the current predicament of religion revisionism in Uganda,The major objective of this thesis shall be to assess how Christian apologetic could be used as an effective response to the religion revisionism in Uganda using a case of the Faith of Unity religion.,
 Uganda 2024-02-29 17:00:28 2027-03-01 Social Science and Humanities Non-Clinical Trial Degree Award
Asaph Katarangi Kaburura
ID: UNCST-2024-R004200
 TALENT MANAGEMENT PRACTICES, ORGANIZATIONAL CULTURE, EMPLOYEE ENGAGEMENT AND PERFORMANCE OF MINISTRIES, DEPARTMENTS AND AGENCIES IN UGANDA
REFNo: SS4399ES

To examine the relationship between talent management practices and performance of MDAs in Uganda.

To examine the relationship between organisational culture and performance of MDAs in Uganda.

To establish the relationship between employee engagement and performance of MDAs in Uganda.
To examine the relationship between Talent management practices and employee engagement within MDAs in Uganda.

To establish the relationship between organizational culture and employee engagement within MDAs in Uganda.

To establish the mediating effect of employee engagement in the relationship between talent management practices and performance of MDAs in Uganda

To establish the mediating effect of employee engagement in the relationship between organizational culture and performance of MDAs in Uganda.

 Uganda 2025-11-04 18:26:49 2028-11-04 Social Science and Humanities Non-Clinical Trial Degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 End of Project Evaluation for the Baylor Uganda SNAPS WEST Project
REFNo: HS227ES

Evaluation goal The goal of the evaluation is to establish the impact of SNAPS WEST project on HIV service delivery in the Rwenzori region. Evaluation Objectives General objective The general objective is to conduct an end of project evaluation to assess the extent to which the project has met the objectives as stated in the Funding Opportunity Announcement that led to this award. Specific objectives 1) To determine the extent to which “Strengthening National Paediatric HIV/AIDS and Scaling up Comprehensive HIV/AIDS Services in the Republic of Uganda under The President’s Emergency Plan For AIDS Relief project”: i. Scaled up access to paediatrics and adolescent HIV/AIDS/TB care and treatment at COE between 2012 and 2018 ii. Scaled up access to comprehensive HIV care and treatment services in the 7 districts of Rwenzori region between 2012 and 2018. iii. Supported MoH and its partners in a) Strengthening National Paediatric/Adolescent HIV/AIDS Care , b) providing training, mentorship and technical support supervision to RRHs and lower health facilities providing HIV care and ART services, c) providing expert consultation to health workers through the national paediatric and adolescent call centre. iv. Strengthened implementation of district based programming approach as well as support for integration of GHI principles into comprehensive HIV/AIDS care and treatment and other health services over the project period. 2) To assess the relevance of: i. The SNAPS WEST project strategies to the implementers (MOH, districts & Baylor Uganda Clinical Centre of Excellence staff) as well project challenges & recommendations for HIV programing in regard to HTC, PMTCT, Care and Treatment, SMC, OVCs, PP/KPs. ii. The SNAPS WEST project to; a) the HIV care needs of clients in the Rwenzori region and COE, b) as well as information needs for health workers using services of the national paediatric call centre. 3) Document project lessons learnt, challenges faced and make appropriate recommendations
Uganda 2018-08-31 2021-08-31 Medical and Health Sciences Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Host Genetic Factors in Pediatric HIV/TB Infections II
REFNo: HS236ES

The cohort development core project of CAfGEN has several unique and innovative features. 1. This project will significantly expand what is currently the largest genomic cohort dedicated to pediatric HIV in Africa. 2. We will prospectively identify and recruit a cohort of HIV-positive, isoniazid naïve children with a strong exposure to TB, but without evidence of active TB disease – such TB resistant individuals are unique and highly desired in the field, even more so among children co-infected with HIV. This approach is highly conducive to high-level genetic mapping and thus has the potential to offer novel molecular insights into the development of active TB disease. 3. The current studies propose the expansion of our genomics studies to Swaziland – a Southern African population that is currently not represented on the African genomics map. This creates long-term opportunities to fulfill the stated desire to make the H3Africa initiative truly pan-African in scope. 4. The network will develop and extend the experience gained and lessons learned in implementing and pursuing genomics education and ethics consultation in furtherance of the mandate of engaging communities in genomics studies, which is key to long-term sustainability.
Uganda 2018-09-24 2021-09-24 Medical and Health Sciences Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Project Evaluation Protocol for the ACE-FORT Project: Entitled; “Accelerating Epidemic Control in Fort Portal Region in the Republic of Uganda under the President’s Emergency Plan for AIDS Relief (PEPFAR)”
REFNo: HS740ES

i) To determine the extent to which the project; a) Increases the proportion of PLHIV with known HIV status by 2020, b) Increases the proportion of people diagnosed with HIV accessing ART by 2020, c) Increases proportion of people receiving ART who are virally suppressed by 2020, d) Achieves coverage of high impact combination prevention interventions in scale-up districts by 2020, e) Provides Healthy, Safe, Stable, Schooled, and case management services along the Continuum of Response to eligible OVC and their families and graduate families out of Vulnerability by 2023, f) Strengthens regional and district governance and systems for sustained epidemic control by 2023.
ii) To Assess the relevance of; a) Prevention services in reducing the incidence of HIV in Fort portal region, b)Treatment and care services in reducing HIV related morbidity and mortality, c) OVC services in reducing the vulnerability of families with HIV.
iii) To assess the potential for sustainability of project components, results achieved and other efforts aimed at achieving HIV epidemic control in Fort Portal region.
iv) To assess the cost of; a) identifying new HIV positive children and adults, b) retaining HIV positive clients in care, c) graduating OVC’s from vulnerability.

 Uganda 2020-08-26 2023-08-26 Medical and Health Sciences Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Novel and Optimized Diagnostics in Pediatric Tuberculosis in Kampala, Uganda(NOD)
REFNo: HS1341ES

The study has the following objectives:
Objective 1: Evaluate and develop novel assays that diagnose TB by detecting Mycobacterium tuberculosis (MTB) bacterial products in non-sputum body fluids. Objective 2: Evaluate and develop novel assays that diagnose TB by detecting host biomarkers in non-sputum body fluids.
Objective 3: Identify combinations of assays that applied together could be used to diagnose TB among children with unconfirmed.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Mortality Surveillance Activity Protocol All-cause Mortality Surveillance in Bunyangabu, Kabarole and Kyenjojo districts, Uganda
REFNo: HS1755ES

the objective of establishing a mortality surveillance system is to enumerate and document all-cause mortality in the 3 districts of Bunyangabu, Kabarole, and Kyenjojo in Uganda. Specifically this will; a) determine HIV/AIDS related and proportionate mortality rate in the three districts, b) determine maternal and neonatal mortality rates in the three districts c) identify causes of death among HIV patients and causes of pregnancy-related deaths in the three districts and d) document the implementation process of mortality surveillance in order to inform future scale up.
 Uganda 2021-10-12 2024-10-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 BREATHER Plus: A randomized open-label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir- based triple ART in virologically suppressed HIV-infected adolescents aged 12 to 19 years of age in sub-Saharan Africa, Version 2.0, Dated 18-Mar-2020; ISRCTN #: 85058577
REFNo: HS1822ES

Major Objective: A randomized open-label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir-based triple ART in virologically suppressed HIV-infected adolescents aged 12 to 19 years of age in sub- Saharan Africa
Specific Objectives
To evaluate an innovative and contemporary ART strategy in HIV-infected adolescents to provide choice for young people facing life-long treatment. Output from this RCT will provide evidence on efficacy, safety and acceptability of a novel treatment approach in HIV-infected adolescents in sub-Saharan Africa
To evaluate the virological efficacy, safety, acceptability and Quality of Life of DTG-based Short-cycle Therapy with weekends off compared with Continuous Therapy with a DTG- based ART regimen
To optimize treatment for HIV-infected adolescents in sub-Saharan Africa

 Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Clinical Trial Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Results Based Financing to achieve HIV/AIDS epidemic control in Fort Portal Region, Uganda A case study of Baylor-Uganda
REFNo: HS2227ES

The objectives of the RBF pilot include the following; a) To determine the effect of results-based financing on the performance of HIV and TB indicators in Fort Portal region, b) To estimate and compare cost to outcome ratios for performance on selected HIV/TB indicators before and after RBF implementation in selected health facilities and c) To describe the process and contextual factors affecting implementation of RBF for HIV indicators under the ACE-Fort project in Fort Portal region.
 Uganda 2022-05-20 8:30:01 2025-05-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 IMPAACT 2028: Long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV; DAIDS Study ID #38693
REFNo: HS2417ES

To characterize the long-term clinical, immunologic, and Virologic profiles of children who received early treatment for perinatally-acquired HIV
 Uganda 2023-02-06 16:17:13 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 An evaluation protocol by Baylor-Uganda titled: Leveraging on the Orphan and Vulnerable Children (OVC) platform to Improve TB case finding, TB Preventive therapy and TB treatment outcomes under ACE-FORT Project
REFNo: HS2534ES

1) Conduct a baseline TB/HIV performance indicator assessment among OVC supported under the ACE-Fort project.
2) Compare TB case finding, prevention and treatment outcomes before and after implementing accelerated TB-OVC integrated services,
3) Describe geographical hotspots with high number of OVC with TB under the ACE-Fort Project.,
4) Evaluate adoption and contextual factors influencing implementation of the accelerated TB-OVC integration services by CSO staff,
5) Estimate the cost of implementing accelerated TB-OVC integration services under the ACE-Fort Project.

Uganda 2022-11-28 11:40:05 2025-11-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Long-Acting Treatment in Adolescents (LATA); A randomized open-label 2-arm 96-week trial in virologically suppressed HIV-1-positive adolescents aged 12-19 years of age in Sub-Saharan Africa version 1.0 dated 01 December 2021.
REFNo: HS2515ES

• To evaluate an innovative and contemporary ART strategy in HIV- positive adolescents to provide choice for young people facing life-long treatment.
• To evaluate the virological efficacy, safety, acceptability, and quality-of-life of the dual long-acting injectable combination, cabotegravir and rilpivirine, antiretroviral therapy compared to continuous daily oral therapy with triple oral ART consisting of DTG with a backbone of tenofovir either as the TAF or TDF formulations, combined with either 3TC or FTC regimen, to optimize treatment for HIV-positive adolescents in sub-Saharan Africa.

 Uganda 2026-01-27 19:28:37 2029-01-27 Medical and Health Sciences Clinical Trial Non-degree Award
AKELLO REBECCA AGNESS
ID:
PREVALENCE, SEVERITY AND FACTORS ASSOCIATED WITH ANAEMIA AMONG WOMEN ADMITTED FOR DELIVERY AT TERM AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS3067ES

3. To identify the factors associated with anaemia among women admitted for delivery at term at Mbarara Regional Referral Hospital,2. To describe the severity of anaemia among women admitted for delivery at term at Mbarara Regional Referral Hospital ,1. To determine the prevalence of anaemia among women admitted for delivery at term at Mbarara Regional Referral Hospital ,To determine the prevalence, severity and factors associated with anaemia among women admitted for delivery at term at Mbarara Regional Referral Hospital.,
 Uganda 2023-10-23 13:09:03 2026-10-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Jackline  Akello
ID: UNCST-2023-R005827
 Sickle cell disease in pregnancy: Experiences in provision and access to care and adverse pregnancy outcomes at Mbale and Kawempe Referral Hospitals
REFNo: HS5315ES

4.To explore health providers experiences in providing care to pregnant women with SCD at Mbale and Kawempe referral hospitals. ,To explore experiences of pregnant women with SCD in accessing health care at Kawempe and Mbale referral Hospitals. ,2.To determine risk factors for adverse fetal outcomes among pregnant women with SCD at Mbale and Kawempe Referral Hospitals,To determine risk factors for adverse maternal outcomes among pregnant women with SCD at Mbale and Kawempe Referral Hospitals ,The general objective is to determine the adverse maternal and fetal outcomes associated with pregnancies complicated by SCD and explore experiences in access and provision of care at Mbale and Kawempe Referral Hospitals. ,
 Uganda 2025-01-10 11:54:49 2028-01-10 Medical and Health Sciences Non-Clinical Trial Degree Award
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