Adoke Yeka
ID: UNCST-2021-R004300
|
Efficacy and safety of artemether-lumefantrine, pyronaridine-artesunate, artesunate-amodiaquine and dihydroartemisinin – piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda.
REFNo: HS1363ES
The general objective of this study is to assess the therapeutic efficacy and safety of artemether-lumefantrine (AL), pyronaridine-artesunate (PA), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DP) for the treatment of uncomplicated P. falciparum malaria in three sentinel sites in Uganda.
The primary objectives are:
• to measure the clinical and parasitological efficacy of 4 artemisinin-based combination therapies (ACT), artemether-lumefantrine (AL) Pyronaridine-artesunate (PA), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DP).
• to differentiate recrudescence from new infection of Plasmodium falciparum by molecular techniques.
The secondary objectives are:
• to evaluate the incidence of adverse events; and
• to determine the polymorphism of molecular markers mediating resistance for Artemsinin, Pyronaridine, Piperaquine and Lumefantrine resistance.
• to determine the blood concentration of Lumefantrine after treatment with Artemether- Lumefantrine .
|
Uganda |
2021-07-08 |
2024-07-08 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
An adaptive, randomized, active-controlled, open-label, sequential cohort,
multicenter study to evaluate the efficacy, safety, tolerability and
pharmacokinetics of intravenous cipargamin (KAE609) in adult and pediatric
participants with severe Plasmodium falciparum malaria (KARISMA –
KAE609’s Role In Severe Malaria)
REFNo: HS1980ES
Primary objective
To assess the efficacy of different doses of
intravenous cipargamin vs artesunate by evaluating the proportion of
participants with ? 90% reduction of parasitemia at 12 hours post
administration of the first dose.
Secondary Objectives
1. To assess the presence/absence of severe malaria related individual
signs over time
2. To evaluate parasite clearance dynamics and proportion of participants
with recrudescence and reinfection
3. To assess recovery of participants as measured by time (days and hours)
to discharge from hospital or recovery from prostration
4. To evaluate the safety and tolerability of IV cipargamin
5. To assess the risk of long term neurological sequelae for participants at
Day 29
6. The assess the risk of hemolysis (early and delayed) during the study
duration
7. To characterize the plasma pharmacokinetics of IV cipargamin
|
Uganda |
2023-08-18 9:05:14 |
2026-08-18 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
Phase IIa Proof of Concept, Multicenter, Randomized, Open-label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of the Combination M5717 plus Pyronaridine Administered once Daily for 1 or 2 Days to Adults and Adolescents with Acute Uncomplicated Plasmodium falciparum Malaria
REFNo: HS2736ES
To evaluate the safety and
tolerability of the M5717-
pyronaridine combination in
adult participants with acute
uncomplicated malaria due to
P. falciparum.
Secondary.
o describe the clinical efficacy
of the M5717-pyronaridine
combination in adult participants
with acute uncomplicated
malaria due to P. falciparum
|
Uganda |
2023-03-16 12:35:56 |
2026-03-16 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
PLATINUM: A multi-part, multi-center PLATform study to assess the efficacy, safety, tolerability and pharmacokinetics of anti-malarial agents administered as monotherapy at multiple dose levels and/or combination therapy IN patients with Uncomplicated Plasmodium falciparum Malaria.
REFNo: HS2817ES
Part A: To assess the parasite clearance time (PCT) of oral doses of an anti- malarial agent administered as monotherapy in patients with uncomplicated
P. falciparum malaria
Part B: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as combination therapy versus the standard of care (SoC) in patients with uncomplicated P. falciparum malaria.
Part A: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as monotherapy in patients with uncomplicated
P. falciparum malaria
Part B: To assess the parasite clearance time (PCT) of oral combinations of anti-malarial agents versus SoC in patients with uncomplicated P. falciparum malaria
All parts:
To characterize PK of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy [Part B] in patients with uncomplicated P. falciparum malaria
To assess the safety and tolerability of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy versus SoC [Part B] in patients with uncomplicated P. falciparum malaria
|
Uganda |
2023-09-26 11:55:15 |
2026-09-26 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
A pilot study evaluating the feasibility, acceptability and impact of use of highly sensitive malaria RDTs (NxTek™) vs ordinary malaria RDTs on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS2988ES
1. To determine the impact of detecting and treating additional malaria cases on malaria morbidity, 2 years following introduction of HS-RDTs for diagnosis of malaria in Uganda.
2. To assess feasibility of use (ease of test interpretation, delivery, restocking, storage, invalid tests, and reporting rates) of HS-RDTs among implementers in Uganda.
3. To compare clinical care outcomes for malaria cases diagnosed with HS-RDTs and cRDTs in Uganda.
4. To estimate the cost-effectiveness of delivering HS-RDTs, as compared to cRDTs.
|
Uganda |
2023-08-18 9:13:55 |
2026-08-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
A randomized, open-label, multicenter study to compare efficacy, safety and tolerability of KLU156 with Coartem® in the treatment of uncomplicated Plasmodium falciparum malaria in adults and children ≥ 5 kg body weight followed by an Extension phase with repeated KLU156 treatment.
REFNo: HS3732ES
This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination of ganaplacide (KAF156) and a solid dispersion formulation of lumefantrine (lumefantrine-SDF), when administered once daily for three days in adults and children ≥ 5 kg body weight and ≥ 2 months of age suffering from uncomplicated P.Falciparum malaria (with or without other plasmodium spp. co-infection). In the Extension phase, the safety, tolerability and efficacy of repeated treatment with KLU156 will be assessed for a maximum of two years in patients who did not experience early treatment failure(ETF), who did not experience any study treatment-related SAE (Serious Adverse Event) previously and who gave informed consent to participate in the Extension phase.
|
Uganda |
2024-05-29 9:37:35 |
2027-05-29 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
Assessing durability of PermaNet Dual and PermaNet 3.0 under field conditions in Northern Uganda.
REFNo: HS5657ES
1. To compare the attrition and physical integrity of PermaNet Dual nets to PermaNet 3.0 nets in multiple locations across Northern Uganda over a three-year period, and to estimate median LLIN survival.
2. To characterize the chemical and entomological attributes of PermaNet 3.0 and PermaNet Dual nets over a period of three years after the mass distribution campaign.
3. To provide insight into the community acceptance of PermaNet Dual relative to PermaNet 3.0, and describe social and behavioural aspects related to net use and net care.
4. To assess the impact of net use and net care practices on the functional survival and insecticidal activity of the LLINs across the districts and across time.
|
Uganda |
2025-04-02 8:50:02 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
Randomised controlled trial to assess the efficacy of artemisinin combination therapies in a setting of emerging artemisinin resistance in Uganda.
REFNo: HS6327ES
To assess the 42-day clinical and parasitological efficacy of artemether-lumefantrine (AL) and pyronaridine-artesunate (PA) for the treatment of uncomplicated P. falciparum malaria in Uganda.
|
Uganda |
2025-09-09 16:41:47 |
2028-09-09 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Adoke Yeka
ID: UNCST-2021-R004300
|
An open-label, randomised, controlled, non-inferiority trial to compare the efficacy, safety and tolerability of a fixed dose Triple Artemisinin-based Combination Therapy (TACT) artemether-lumefantrine-amodiaquine versus first-line Artemisinin-based Combination Therapies (ACTs) for the treatment of uncomplicated Plasmodium falciparum malaria
REFNo: HS6344ES
To compare the efficacy of ALAQ vs AL and ALAQ vs ASAQ as defined by the 28-day PCR corrected adequate clinical and parasitological response (ACPR).
|
Uganda |
2025-09-26 17:41:17 |
2028-09-26 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Justine Yapsoyekwo
ID:
|
IMPLEMENTATION OF CAREER EDUCATION AND DUAL CAREER DEVELOPMENT: A COMPARATIVE STUDY OF ACADEMIC AND SPORTS CAREER DEVELOPMENT AMONG STUDENTS IN SEBEI SUB-REGION
REFNo: SS1252ES
General Objective
The general objective of the study is to examine the influence of implementation of career education on dual career development with a view to compare academic and sports career development among students in secondary schools in Sebei sub-region in Eastern Uganda.
Specific Objectives
i. To investigate the influence of identification of career needs on dual career development among students in secondary schools in Sebei sub-region.
ii. To establish the influence of development of career opportunities on dual career development among students in secondary schools in Sebei sub-region.
iii. To assess the influence of integration of students needs with career opportunities on dual career development among students in secondary schools in Sebei sub-region.
iv. To examine the influence of regular monitoring of students career development on dual career development among students in secondary schools in Sebei sub-region.
|
Uganda |
2022-05-24 12:36:09 |
2025-05-24 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Yasuka Tateishi
ID: UNCST-2025-R022932
|
Impact of Urban Flooding on Businesses in Kampala
REFNo: SS4689ES
This study examines how extreme rainfall and recurring urban flooding disrupt firms in Kampala and what these disruptions may imply for long-term firm growth. The focus is on medium- to large-sized firms in the manufacturing, wholesale, and retail sectors operating in urban areas. The study aims to document firms’ exposure to flooding and characterises the frequency and duration of flood-related interruptions. It identifies the main channels through which flooding affects business activity, including direct disruptions at business premises and indirect disruptions transmitted through reduced urban connectivity that constrains access to workers, customers, suppliers, and road network. The study also examines how firms perceive flood risk, whether these perceptions influence location and planning decisions, and which coping and adaptation strategies firms adopt to maintain operational continuity. In doing so, it provides evidence on the patterns of firm vulnerability and resilience to flooding in Kampala and generates inputs that can support the design of targeted urban resilience and private sector support policies.
|
Japan |
2026-02-05 22:00:27 |
2029-02-05 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Yasushi Miyauchi
ID: UNCST-2023-R005483
|
Analysis of excitatory amino acids in Ustilago maydis of maize and sorghum in northern Uganda.
REFNo: A475ES
To measure the amount of each excitatory amino acid contained in Ustilago maydis of maize and sorghum by using Gas Chromatography,
|
Japan |
2024-12-10 15:01:21 |
2027-12-10 |
Agricultural Sciences |
Non-Clinical Trial |
Degree Award |
|
Yusuf Byaruhanga Byenkya
ID:
|
Locally-driven co-development of plant-based value chains towards more sustainable African food system with healthier diets and export potential (InnoFoodAfrica)
REFNo: SS1422ES
Main Objective
1. InnoFoodAfrica aims to develop new sustainable value chains (VC) to produce and distribute diverse and healthy foods from African farms to local and export markets.
Specific Objectives
1. Develop resource-efficient, safe and sustainable food production VCs by empowering small-holder farmers, processors, producers and consumers via co-creation process with African and European experts,
2. Catalyzing new local and international business and market opportunities in the cereal-pulse-root crop-fruit food and packaging VCs by engaging VC actors and investigating new business models.
3. Adapt and implement dietary guidelines that are based on cereal-pulse-root crop-fruit-based foods and diets tackling malnutrition of small children (focusing also on the health of expecting and breast-feeding mothers who are responsible for taking care of themselves and their children within the first 1000 days of life) and adults under the risk of obesity.
4. Diversify of plant-based agrofood systems enabling nature-benefiting farming and production of African food, which form a basis for a balanced diet.
5. Develop safe and nutrient-dense cereal-pulse-root crop-fruit-based food ingredients and products which tackle malnutrition from two angles: nutrient deficiencies and obesity, taken into account both children (<1000 days) and adult consumer segments.
6. Increase resource-efficiency of the African cereal-pulse-root crop-fruit-based food VCs by reducing food loss and food waste by improved post-harvesting and storage practices, and by creating value from side streams via bio-based packaging solutions for replacement of plastic.
7. Establish a pan-African food R&D&I (research, development and innovation) community via cooperation and creation of an open Innovation Platform, and 2) contribution to goals of the EU-Africa Research and Innovation Partnership within FNSSA and cooperation with ongoing projects in the subject area to share innovations, maximize communication and facilitating technology transfer.
|
Uganda |
2022-09-15 11:46:33 |
2025-09-15 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Peter Yiga
ID:
|
Fresh fruit and vegetable consumption in Uganda; barriers, facilitators and current consumption practices
REFNo: HS2552ES
1. To understand consumer motives and barriers to / not to consume (specific) fruits and vegetables
2. To know the proportion of target market consumers who demonstrate a preference to deliberately avoid unsafe sprayed FFV products in favour of safe FFV
3. To know what consumers do with the FFV they purchase and whether it affects their nutritional value and food safety
4. To know how processing of FFV products respond to consumer needs
5. To get insights on strategies that show potential to drive the consumption of FFV in Uganda
|
Uganda |
2022-11-28 11:57:58 |
2025-11-28 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Yerusa Kiirya
ID:
|
Acceptability, Feasibility and Effectiveness of a WhatsApp peer support group as a strategy to improve antiretroviral therapy adherence among youth in Kampala District
REFNo: SIR170ES
To determine the effectiveness of a WhatsApp peer support group combined with the standard of care in improving ART adherence among YLHIVA aged 15-24 years in Kampala district.,To determine the effect of a WhatsApp peer support group combined with the standard of care on psychosocial barriers to ART adherence and retention in care among YLHIVA aged 15-24 years in Kampala district.,To assess the feasibility of using a WhatsApp peer support group combined with the standard of care as an ART adherence and retention in care strategy among YLHIVA aged 15-24 years, To asses the acceptability of a WhatsApp peer support group combined with the standard of care as an ART adherence and retention in care strategy among YLHIVA aged 15-24 in Kampala district.,To assess the acceptability, feasibility and effectiveness of a WhatsApp peer support group combined with current standard care as a strategy to improve ART adherence among YLHIVA in Kampala.,
|
Uganda |
2023-01-20 14:23:51 |
2026-01-20 |
Engineering and Technology |
Clinical Trial |
Degree Award |
|
Yume Nomoto
ID:
|
A comparison of nutritional status among children under five years of age between refugee and host communities: A multi-sectoral cross-sectional study in Lamwo district, Uganda
REFNo: SS1640ES
To estimate determinants of nutritional status among children in refugee and host communities,To estimate the difference in the prevalence of malnutrition among children between refugee and host communities,To estimate the difference in nutritional status among children 0-59 months of age between refugee and host communities.,
|
Japan |
2023-05-18 15:50:51 |
2026-05-18 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Yona Mbalibulha
ID:
|
Maternal Rh-Alloimmunization and Haemolytic Disease of the Newborn in South Western Uganda: alloantibodies profile and associated risk factors
REFNo: HS508ES
1. To establish the Rh antigen profile (i.e. C, c, D, E, and e antigens) among pregnant women in South Western Uganda.
2. To determine the prevalence of anti-Rh alloimmunization and the alloantibody identity among alloimmunized pregnant women in South Western Uganda.
3. To determine the anti-Rh antibody titers and the association to incidence of Hemolytic Disease Newborn in alloimmunized pregnant women
4. To identify risk factors for the presence of alloantibodies in pregnant women in south western Uganda
|
Uganda |
2020-02-11 |
2023-02-11 |
Medical and Health Sciences |
|
Degree Award |
|
Yvonne Mugerwa Kidza Kitego
ID:
|
The Kampala Slum Maternal Newborn (MaNe) Project - Innovating for Better Referral Systems: an implementation research protocol
REFNo: HS962ES
• To harness the public and private facility mix to provide quality and affordable maternal and newborn care services to the urban poor.
• To strengthen referral linkages between public and private health facilities for MNH care.
• To educate mothers, caretakers of newborns and spouses about appropriate actions on what MNH services to seek and from where
|
Uganda |
2021-01-06 |
2024-01-06 |
Medical and Health Sciences |
|
Non-degree Award |
|
Yvonne Mugerwa Kidza Kitego
ID:
|
Heat-stable Carbetocin for Postpartum Hemorrhage prevention and Tranexamic Acid for PPH treatment in Basic Emergency Obstetric and Newborn Care facilities: Protocol for a pilot study in humanitarian settings in Uganda
REFNo: HS2456ES
The specific objectives of the study are to 1. To explore the feasibility, acceptability, and scalability of introduction of HSC and TXA in PPH prevention and management (as per WHO PPH guidelines) in BEMONC facilities in Humanitarian settings in Uganda. 2. To identify facilitators and barriers to successful introduction of HSC and TXA for PPH prevention and management (as per WHO PPH guidelines) in BeMONC facilities in Humanitarian settings In Uganda. (Including facilitators and barriers to introduction of and adherence to the WHO PPH guidelines in general). 3. To describe the effect (on quality of maternal and newborn health care) of introduction of a package of interventions that includes a) refresher training on PPH prevention and management (as per WHO and MOH guidelines) and b) introduction of HSC and TXA for PPH prevention and management of PPH in BEMONC facilities in Humanitarian settings in Uganda. ,
|
Uganda |
2022-10-13 13:10:55 |
2025-10-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Honoka Yokoyama
ID: UNCST-2024-R002478
|
A Study of the Educational Relationship between Teachers and Students in Ugandan Secondary Schools
REFNo: SS3639ES
The purpose of this study is to clarify how the educational relationship between teachers and students is constructed in diverse relationships under the respective rationales of teachers and students, focusing on situations such as daily student guidance and learning.
|
Japan |
2025-09-23 10:52:39 |
2028-09-23 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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