Helen Byakwaga
ID: UNCST-2019-R001168
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A Phase III/IV factorial randomised double-blind trial to compare the addition of dapagliflozin versus placebo, and rosuvastatin/ezetimibe versus pitavastatin, in patients with HIV on integrase strand transfer inhibitor-based antiretroviral therapy with elevated metabolic risk (Optimising metabolic management on integrase-based antiretroviral therapy – the OPTIMAR Study)
REFNo: HS5819ES
To assess the impact of pitavastatin vs. rosuvastatin/ezetimibe from baseline to 48 weeks on: fasting lipids, cardiovascular disease risk assessment measures; inflammatory biomarkers; and safety and tolerability,To assess the impact of dapagliflozin vs. placebo from baseline to 48 weeks on: intermediate markers of cardiovascular disease risk; cardiovascular disease risk assessment measures; clinical consequences of increased body weight; and safety and tolerability of dapagliflozin,To assess the impact of pitavastatin vs. rosuvastatin/ezetimibe on LDL concentration change from baseline to week 24,To assess the impact of dapagliflozin vs. placebo on absolute weight change from baseline to week 24,The overall objective of the study is to examine the impact of dapagliflozin vs. placebo on metabolic parameters in PWH with high metabolic risk who are on INSTI-based ART.,
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Uganda |
2025-09-30 14:11:23 |
2028-09-30 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Hang ZHOU
ID:
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Bring African Bureaucracies back in: Negotiations and Implementation of Chinese Development Engagement in Uganda
REFNo: SS125ES
This project seeks to take African bureaucracies seriously, an actor that has largely neglected in the existent literature. Taking an empirically grounded approach, this project aims to study the real governance of African bureaucracies and investigating what they actually do without classifying them into pre-determined ideal-typical categories.
More specifically, using China-Uganda development engagement in road construction and agriculture sectors as a case study, this project conceives this development engagement as ‘processes of negotiation, contestation and bricolage’ through which Ugandan bureaucrats together with local, national and Chinese actors seek to articulate their preferred positions and fulfil the mandates of their organisations.
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China |
2017-11-08 |
2020-11-08 |
Social Science and Humanities |
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Degree Award |
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Provia Ainembabazi
ID:
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BREAST CANCER RISK PERCEPTION AND RISK REDUCTION BEHAVIOURS OF FIRST DEGREE FEMALE RELATIVES OF BREAST CANCER PATIENTS AT UGANDA CANCER INSTITUTE, KAMPALA, UGANDA
REFNo: HS277ES
General Objective
The general objective of this study is to explore self-perceived risk of breast cancer and intentions for screening and adoption of risk reduction behaviors among first degree female relatives of breast cancer patients attending Uganda Cancer Institute so as to inform design of interventions to enhance uptake of early detection and prevention services.
Specific Objectives
1. To explore self-perceived risk of breast cancer and intended risk reduction behaviors among first degree female relatives of breast cancer patients at UCI.
2. To determine factors associated with self-perceived risk of breast cancer among the first degree female relatives of breast cancer patients at the UCI.
3. To determine the factors associated with risk-reduction behaviors among the first degree female relatives of breast cancer patients at UCI
4. To describe perceived barriers for adoption of risk reduction behaviors among first degree female relatives of breast cancer patients at the UCI.
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Uganda |
2019-02-12 |
2022-02-12 |
Medical and Health Sciences |
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Non-degree Award |
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Hannington Gumisiriza
ID:
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EXTRACTION, ISOLATION AND CHARACTERISATION OF THE BIOACTIVE COMPOUNDS FROM THE LEAVES OF GOUANIA LONGISPICATA
REFNo: NS34ES
1. Isolation of the phytochemical constituents of Gouania longispicata leaves.
2. Phytochemical screening of the crude extracts
3. Determining the antimicrobial activity of the extracts against Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Escherichia coli.
4. Antioxidant and cytoxicity studies on the most active extract
5. Structure elucidation of the compounds isolated from the most active extract against the selected organisms
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Uganda |
2017-11-14 |
2020-11-14 |
Natural Sciences |
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Degree Award |
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Anaclet Namanya Mutiba
ID:
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Teachers' Understanding and Classroom Practices of Quality Education in Ugandan Primary Education: A Case of Bushenyi District
REFNo: SS124ES
The main study objective is to find out how teachers understand and practice quality education in Ugandan primary education.
The specific objectives are:
(i) To find out how teachers understand neoliberal policies in relation to quality education.
(ii) To establish how teaching and instruction processes reflect quality education.
(iii) To find out factors that influence teaching and instructional processes and methodology.
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Uganda |
2017-10-31 |
2020-10-31 |
Social Science and Humanities |
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Degree Award |
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Stephanie Grand
ID:
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Volcanic inputs in soils of the Albertine Rift Valley: implication for modern soil biogeochemistry
REFNo: NS33ES
1. Identify the geochemical signature of recent volcanic eruptions products in the area based on the literature and lab analyses of grab samples of volcanic rocks.
2. Look for evidence of volcanic influence in modern soils using geochemical and mineralogical analyses of soil samples collected at different locations and different landscape positions
3. Analyze the link between inferred volcanic inputs and soil fertility
4. Formulate recommendations for integrating pedologic and geochemical information into agricultural sustainability studies
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France |
2017-11-08 |
2020-11-08 |
Natural Sciences |
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Non-degree Award |
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Fredrick Kabi
ID:
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EVALUATION OF THE SAFETY, EFFICACY AND EFFECTIVENESS OF THE SUBOLESIN BASED ANTI-TICK VACCINE: A RANDOMISED DOUBLE BLINDED MULTI-SITE CONFINED FIELD TRIAL
REFNo: A191ES
OVERALL OBJECTIVE
Evaluation of the Safety, Efficacy and Effectiveness of Subolesin based Anti-tick Vaccine for control of ticks naturally infesting different cattle breeds under confined field conditions in Uganda.
SPECIFIC OBJECTIVES
I. To determine the safety of the injectable Subolesin based Anti-tick vaccine for control of tick infestations under natural confined field conditions.
II. To determine the efficacy of the injectable Subolesin based Anti-tick vaccine for control of tick infestations under natural confined field conditions.
III. To determine the effectiveness of the injectable Subolesin based Anti-tick vaccine for control of tick infestations under natural confined field conditions.
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Uganda |
2022-10-21 12:58:12 |
2025-10-21 |
Agricultural Sciences |
Clinical Trial |
Non-degree Award |
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Fiona Cresswell
ID:
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High dose oral and intravenous rifampicin for adult tuberculous meningitis: an open-label phase II randomised controlled trial
REFNo: HS136ES
1. To determine whether higher-dose rifampicin, delivered orally at 35mg/kg/day or delivered intravenously at 20 mg/kg/day (for 2-weeks, followed by orally at 35 mg/kg/day for 6-weeks) provide equivalent plasma and CSF exposures, and whether the exposure profiles are favourable compared to the standard dose oral rifampicin. The pharmacokinetically optimal dose and route of administration of rifampicin can then be taken forward into a phase III clinical trial.
2. To observe whether greater rifampicin exposure in CSF is associated with any clinical benefit including more rapid resolution of coma, reduced neurocognitive deficit or reduced mortality.
3. To determine the diagnostic accuracy of Xpert MTB/Rif Ultra for TBM (ancillary study 1)
4. To describe the concentration of rifampicin in brain tissue in each treatment arm (ancillary study 2)
5. To explore the use of bedside ultrasound as a monitoring tool to improve supportive care for people with TBM (ancillary study 3)
|
UK |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Chienwen Kao Jennifer
ID:
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Mapping Social Networks of Child Caregiving in Uganda: A Formative Mixed Methods Study
REFNo: SS137ES
1. Use qualitative interviews to better understand the caregiving networks of female Ugandan child caregivers
2. Pilot and receive feedback on a novel social network measure designed to measure caregiving networks quantitatively
3. A preliminary exploration of how the captured social network relates to the caregiver’s depression
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Taiwan |
2018-03-12 |
2021-03-12 |
Social Science and Humanities |
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Degree Award |
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Pavel Reppo Aleksandrovich
ID:
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Implementing the MANAS trial in Uganda (MAN U) - The Pilot Phase
REFNo: HS134ES
Research Question & Specific Objectives
Question: How will implementing a trained Community Health Worker (CHW)-led Collaborative Stepped Care Intervention (CSCI) lead to an improvement in recovery from depression among patients within general outpatient attending public primary care facilities in Uganda?
Aim 1: To determine whether treatment from trained CHWs leads to 1) patient recovery from MDD as defined by the DSM-IV at 6 months, and 2) the proportion of patients with above threshold scores (PHQ-9 score of ≥10). Hypothesis: Constituents of collaborative care interventions predicted a favorable outcome.
Aim 2: To increase awareness of CHW-led, collaborative stepped care as a viable option of treatment for depression among trainees, study participants, the community and stakeholders. Relevance: Community views and input are essential to inform the development of a culturally appropriate training curriculum for CHWs.
Aim 3: To determine the outcome of the CHW training on retention of knowledge and skills in competencies required to deliver the stepped care intervention among trainees after the training. Hypothesis: Trained CHWs will demonstrate increased level of knowledge and skills in competencies required to deliver collaborative stepped care after the training.
Aim 4: To determine the perceptions of CHWs, study participants, the community and stakeholders towards the process of integrating CHW-led, collaborative stepped care into community based mental healthcare. Relevance: There is a need to understand the views of participants and stakeholders pre and post to determine project efficacy.
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USA |
2017-10-31 |
2020-10-31 |
Medical and Health Sciences |
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Non-degree Award |
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Joe Abell Nadin
ID:
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A study investigating different perspectives on the use of participatory approaches in HIV prevention work
REFNo: SS123ES
This project will explore the use of participatory methods in HIV prevention work in Uganda. Proponents of the use of participatory methods in HIV prevention would claim that their projects avoid making demands by allowing ordinary people to decide themselves what changes they feel they need to make.
Critics of participatory approaches used in economic development projects have, however claimed that they do not result in any real moves towards transfer of control and that any ‘participation’ involved is essentially cosmetic. Other possibilities are opened up by suggestions that the forms that projects take in order to qualify as participatory can leave them open to contestation and the possibility of resistance from participants.
Through participant observation of prevention projects and interviews with participants, facilitators and the employees of NGOs using participatory methods to carry out HIV prevention work I will explore the dynamics at play and the perceptions of different actors involved when these methods are used in the context of HIV prevention.
Aims:
This project will have two main aims:
1) To explore the different perspectives of participants, organizers, facilitators and planners on the use of participatory methodologies and the dynamics of the implementation process. The main objective here will be to examine people’s expectations regarding participation and their assessments of the degree to which control is handed over. The way in which this will be approached is by testing a hypothesis derived from existing criticisms of participatory methodology: that this methodology does not lead to real changes in the dynamics of development work.
2) To explore the use of the idea of ‘participation’ in the context of HIV prevention work. HIV prevention, which deals with the regulation of sexuality, presents many contrasts with development projects which focus on economic development. This project will examine how prevention projects adapt the concept of participation in this context and the degree to which the idea of participation has to widen to allow this to happen.
Significance and Expected Benefits:
The most direct benefit of this research will be the information that it will make available to organisations planning, developing and implementing HIV prevention work. The project will deliver information on the perceptions of the intended beneficiaries of the HIV prevention work that has been studied. This will include participant’s evaluations of the degree to which the design and implementation of the prevention work resulted in a genuinely participatory experience from their perspective. Contrasting this with views expressed by staff at different level of the implementing organisation will allow any differences in perceptions to be identified, both in terms of the understanding of the ideas behind ‘participation’ and how it works in practice. Having access to this information will be useful to implementing organisations in improving the design of prevention work and putting it into practice. Providing those who have taken part in prevention work as participants with feedback may strengthen their ability to demand changes from providing organisations.
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UK |
2017-11-14 |
2020-11-14 |
Social Science and Humanities |
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Degree Award |
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Jeremy Springman
ID:
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Public Opinion on Service Delivery and NGOs in Uganda
REFNo: SS170ES
Despite staggering growth in the delivery of public services by NGOs, little is known about how this shapes levels of citizen political engagement, confidence in government, and political accountability. This study will use a public opinion survey to measure whether receiving health services from an NGO causes an increase in levels of citizen engagement and confidence in government. To estimate whether receiving NGO-provided services influences the political attitudes of citizens who benefit from them, we will sample individuals in communities that have received NGO services and communities that have not.
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USA |
2018-07-17 |
2021-07-17 |
Social Science and Humanities |
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Non-degree Award |
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Joanne Corbin Nancy
ID:
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Effects of armed conflict and displacement on men's socio-cultural and economic roles in northern Uganda
REFNo: SS119ES
• To examine the impact of armed conflict and internal displacement on men’s socio-cultural and economic roles in Northern Uganda.
• To examine this phenomenon from subjective experiences.
• To explore the adaptations that men have made to deal with any socio-cultural and economic impacts from armed conflict and internal displacement.
• To disseminate the findings from this study in appropriate venues as recommended by Ugandan colleagues and produce an article on the results of this research.
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USA |
2018-03-14 |
2021-03-14 |
Social Science and Humanities |
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Non-degree Award |
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Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
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Needs assessment for the curriculum development and training on new study design for the Research Ethics Committee members at Makerere University and Mulago hospital complex
REFNo: HS542ES
General Objective
To determine the training needs on new study designs amongst REC members so as to generate information necessary for designing a curriculum geared towards building capacity and expertise in review of complex study designs.
Specific Objectives
1. To determine the training needs on new study design amongst the REC members
2. To determine the regulatory guideline gaps that impede the research approval process amongst the REC members
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Uganda |
2020-08-17 |
2023-08-17 |
Medical and Health Sciences |
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Non-degree Award |
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Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
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Optimizing malaria treatment for HIV-malaria co-infected individuals by addressing drug interactions between Artemether-Lumefantrine and Efavirenz.; a randomized trial
REFNo: HS820ES
General Objective: To utilize innovative interventions to overcome drug interactions between artemether-lumefantrine and efavirenz to guide malaria treatment for individuals co-infected with HIV and malaria.
Specific objectives:
1. To determine the safety and Pharmacokinetics of the double dose artemether-lumefantrine when administered with efavirenz based ART among healthy volunteers (malaria negative and HIV negative individuals).
2. To determine the safety and Pharmacokinetics of the 5-day course of artemether-lumefantrine when administered with efavirenz based ART among healthy volunteers (malaria negative and HIV negative individuals).
3. To determine the safety, pharmacokinetics and malaria treatment outcome of a standard dose of artemether-lumefantrine compared to double of the standard dose for weight and a 5-day course of artemether-lumefantrine for treatment of uncomplicated malaria among HIV-Malaria co-infected individuals receiving efavirenz-based ART.
4. To determine the safety and Pharmacokinetics of artemether-lumefantrine when administered with Dolutegravir based ART among HIV-malaria co-infected individuals
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Uganda |
2020-09-04 |
2023-09-04 |
Medical and Health Sciences |
|
Non-degree Award |
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Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
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The Efficacy and Safety of Hydroxychloroquine for The Treatment of Non-Severe Covid-19
REFNo: HS839ES
To compare the viral clearance among adults with non-severe COVID-19 randomized to receive hydroxychloroquine plus standard of care vs. standard of care.
2. To evaluate the safety and tolerability of Hydroxychloroquine among COVID-19 patients in Uganda
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Uganda |
2020-08-13 |
2023-08-13 |
Medical and Health Sciences |
|
Non-degree Award |
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Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
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Evaluation of impact of National Research Information Management System on the research regulatory process in Uganda
REFNo: HS906ES
The general objective of this proposal is to determine the usage of NRIMS as well as evaluate the experiences and attitudes of users of the systems at Makerere University, Mulago Hospital and UCI RECs.
2.1.1 Primary Objective
1. To determine the turnaround time between submission of protocols to review and approval, and time to receipt of feedback from REC for one year before and one year after roll out of NRIMS for RECs in Makerere Hospital Complex and UCI
2.1.2 Secondary Objectives
1. To qualitatively document and compare stakeholders’ experiences regarding use of the paper based and the NRIMS for research protocol review and approval in Makerere University, Mulago Hospital complex and UCI at start of roll out and one year after of roll out.
|
Uganda |
2021-01-25 |
2024-01-25 |
Medical and Health Sciences |
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Non-degree Award |
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Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
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Exposure-Response Evaluation of IV Artesunate in Children with Severe Malaria
REFNo: HS2027ES
Primary:
• To determine the relationship between dihydroartemisinin (DHA) exposures following intravenous dosing and markers of physiologic dysfunction associated with severe malaria
Secondary:
• To determine the relationship between DHA exposures and time to hospital discharge
• To determine the relationship between DHA exposures and parasite clearance associated with treatment of severe malaria.
Exploratory:
• To determine the relationship between DHA exposures and neurodevelopmental outcomes associated with treatment of severe malaria outcomes and explore predictors that may affect this relationship
• To evaluate the role of parasite clearance as a mediator of the relationship between DHA exposures and markers of physiologic dysfunction associated with severe malaria
• To develop a score comprised of markers of physiologic dysfunction and describe its relationship to clinical outcomes
• To assess P. falciparum infections for artemisinin resistance
|
Uganda |
2022-03-14 |
2025-03-14 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
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Perceptions and acceptance of malaria vaccine among caregivers of children admitted with severe malaria in a highly endemic area in Uganda; a mixed methods study
REFNo: HS4059ES
To explore the perceptions of caregivers of children admitted with severe malaria in Tororo General Hospital about malaria vaccine,To investigate the factors associated with the acceptability of malaria vaccine among caregivers of children admitted with severe malaria in Tororo General Hospital in Uganda,To determine the proportion of caregivers of children admitted with severe malaria in Tororo General Hospital who will accept the malaria vaccine,To assess the perceptions and acceptance of malaria vaccine and associated factors among caregivers of children admitted with severe malaria in Tororo General Hospital. ,
|
Uganda |
2024-05-14 9:01:46 |
2027-05-14 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
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Investigation of mpox transmission, disease sequel, and molecular epidemiology in Uganda (Mpoxep)
REFNo: HS5387ES
Primary Objectives
1. To characterize the socio-demographic, clinical, immunological, and virologic epidemiology of Mpox cases in Uganda.
2. To describe the natural history and asymptomatic transmission dynamics of Mpox among contacts.
3. To assess risk factors for clinical hospitalization, ICU admission, and fatal Mpox outcomes.
4. To investigate long-term sequelae among Mpox survivors.
Secondary Objectives
1. To determine the incidence and prevalence of Mpox among high-risk populations (long-distance truck drivers, commercial sex workers, refugees, and PLHA).
2. To assess infection risk and asymptomatic transmission using serology among contacts.
3. To identify risk factors for infection among ‘de novo’ cases with no documented epidemiological link.
4. To explore socio-anthropological factors influencing Mpox transmission, prevention, and care-seeking behavior.
5. To identify potential animal reservoirs of MPXV in Uganda.
6. To describe histopathologic features of Mpox skin lesions and localization of MPXV in different body organs and tissues.
|
Uganda |
2024-12-23 10:56:56 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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