Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Charlotte Hawkins
ID:
The Anthropology of Smartphones and Smart Ageing
REFNo: SS141ES

This project will investigate fundamental changes in people’s relationship to age and health associated with the global rise of the smartphone. The aim is to combine an intellectual challenge in understanding the contemporary nature of age and the impact of new media, with an applied challenge to use this knowledge to help make mHealth (mobile health) interventions more effective. mHealth has potential both for helping those with limited access to professional care but also threatens to bypass and undermine professional medical services. Our aim is to complement technology-led mHealth interventions with ethnography-led participatory design, consisting of a three-way collaboration between mHealth professionals, our ethnographically informed team and our informants in the field. We aim to demonstrate how such collaborations can lead to more culturally appropriate mHealth interventions and more effective improvements in people’s lives.
UK 2018-01-29 2021-01-29 Social Science and Humanities Degree Award
Tiffany Basciano Nicole
ID:
No One Left Behind? A Study on the Human Rights of Women Living With HIV/AIDS in Uganda
REFNo: SS140ES

A study on adult women living with HIV/AIDS in Uganda. The study will include an examination of how women’s rights are integrated into HIV/AIDS-related laws, policies, programs, and initiatives in Uganda. We will further examine any challenges that women may face in family life, healthcare settings, or in the workplace because of their status, as well as any distinction in the experiences of women in urban versus rural settings. We hope that this research will help support the achievement of Sustainable Development Goals (SDGs) 3 – good health and well-being and 5 gender equality.
USA 2018-04-24 2021-04-24 Social Science and Humanities Degree Award
Erik Serrao
ID:
A Clinical Study to Validate the Accuracy and Usability of HemoTypeSCTM, Which is a Novel, Low-Cost, Rapid Diagnostic Test for Sickle Cell Disease
REFNo: HS158ES

The objective of this evaluation protocol is to determine the clinical accuracy of HemoTypeSC in diagnosing SCD-relevant Hb phenotypes (A/A, A/S, A/C, S/S, S/C, and C/C) as compared to “gold standard” HPLC/IEF laboratory testing methodology.
USA 2018-03-27 2021-03-27 Medical and Health Sciences Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
EVALUATION OF THE SAFETY AND EFFICACY OF VECTOCLORÒ-PLUS EMULSIFIABLE CONCENTRATE [E.C.]: A RANDOMISED SINGLE-BLINDED POSITIVE CONTROLLED MULTI-SITE ACARICIDE FIELD TRIAL
REFNo: NS129ES

General objectives
To determine the efficacy and safety of Vectoclor®-Plus E.C. (Ceva Santé Animale, Libourne) hereinafter called Vectoclor®-Plus when used on cattle for tick control.

Specific objectives
-To determine the efficacy of Vectoclor®-Plus when used on cattle for tick control
-To determine the safety of Vectoclor®-Plus when used on cattle for tick control
Uganda 2020-09-15 2023-09-15 Natural Sciences Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Targeting Domestic Animals and Tsetse Fly Vectors to Control Nagana and Accelerate Elimination of Acute Sleeping Sickness from Hot Spot Villages of Eastern Uganda
REFNo: A107ES

The main objective of this study will be to determine whether targeting hotspot villages would accelerate elimination of rHAT The specific objectives of this project will be to determine; i. If rHAT hotspot village-based interventions [two doses of diminazene aceturate 40 days apart at the beginning of the intervention and monthly RAP] will progressively reduce T. brucei s.l. reservoir in cattle and hence insidious rHAT transmission. ii. The drivers of insidious rHAT transmission in hotspot rHAT hotspot villages in Dokolo and Kaberamaido districts.
Uganda 2021-02-25 2024-02-25 Agricultural Sciences Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Prevalence and Economic Importance of Key Endemic Livestock Diseases in Kaabong and Amudat Districts, Karamoja Region
REFNo: NS163ES

The specific objectives of this project will be to determine: -
i.Sero-prevalence of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
ii.Prevalence of Tick-borne hemoparasites [TBHs] in cattle populations from Amudat and Kaabong districts, Karamoja region
iii.Prevalence of helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
iv.Estimates of the socioeconomic impact of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
v.Estimates of the socioeconomic impact of TBHs in Amudat and Kaabong districts, Karamoja region
vi.Estimates of the socioeconomic impact of different helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
Uganda 2021-03-23 2024-03-23 Natural Sciences Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Accelerating Anti-Tick Vaccine Production Using Computational Approaches and Validation with An In-Vivo Model
REFNo: NS165ES

The specific objectives of this study will be to;
i.Create an open access queryable database of candidate anti-tick vaccine protein from I. scapularis proteome
ii.Identify single and chimeric antigenic anti-tick peptides basing on tick-specific amino acid sequences
iii.Evaluate the immunogenicity of five of the most promising antigenic single and chimeric anti-tick peptides in a laboratory animal [three months New Zealand rabbits] model
Uganda 2021-06-10 2024-06-10 Natural Sciences Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Evaluation of the Safety , Efficacy and Stability of Sangatraz-125 & Sangatraz-250: A Randomised Single-Blinded Positive Controlled Multi-Site Acaricides Field Trial
REFNo: A186ES

General objectives To determine the efficacy, safety and stability of Sangatraz-125 & Sangatraz-250(Sanga Vet. Chem. Ltd, Kampala Industrial Park, Namanve ) when applied onto cattle by hand spraying and plunge dipping for tick control. Specific objectives The specific objectives of this acaricide field trial will to to determine; i.efficacy of Sangatraz-125 & Sangatraz-250 when applied onto cattle by hand spraying and plunge dipping for tick control. ii.safety of Sangatraz-125 & Sangatraz-250 when applied onto cattle by hand spraying and plunge dipping for tick control. iii.Stability of Sangatraz-125 & Sangatraz-250 when applied onto cattle by plunge dipping for tick control.
Uganda 2022-04-25 2025-04-25 Agricultural Sciences Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Comparing the Diagnostic Performance of the Rapid Tick Exposure Test (RaTexT) and Larval Packet Test [LPT] for Acaricide Resistance Management in Uganda
REFNo: NS843ES

The general objective of this study will be to determine the diagnostic performance of RaTexT compared to larval packet technique, test a mobile application for its ability to capture acaricide resistance data generated by RaTexT and transmit it to end users as dynamic maps of acaricide resistance as well as determine the gender roles that are likely to underpin successful RaTexT introduction. The specific objectives of this acaricide study will be to determine:
i.Laboratory and field diagnostic performance [specificity, sensitivity, negative and positive predictive values] of RaTexT when used to detect acaricide resistance in tick populations isolated from different agro-ecological zones of Uganda.
ii. Possibility of integrating RaTexT -generated acaricide resistance | susceptibility data into a mobile phone app to allow end-users to create dynamic maps of acaricide resistance in different African ecologies.
iii.Gender-based drivers of successful introduction and sustainable utilisation of RaTexT

Uganda 2024-08-28 17:31:08 2027-08-28 Natural Sciences Non-Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Evaluation of the Safety, Efficacy and Stability of SangaSupa-30% Emulsifiable Concentrate [EC]: A Randomised Single-Blinded Positive Controlled Multi-Site Acaricide Field Trial
REFNo: NS910ES

General objectives
To determine the efficacy, safety, and stability of SangaSupa (Sanga Vet. Chem. Ltd, Kampala Industrial Park, Namanve ) when applied onto cattle by hand spraying and plunge dipping for tick control.
Specific objectives
The specific objectives of this acaricide field trial will to determine;-
i. efficacy of SangaSupa when applied onto cattle by hand spraying and plunge dipping for tick control.
ii. safety of Sangasupa when applied onto cattle by hand spraying and plunge dipping for tick control.
iii. Stability of Sangasupa when applied onto cattle by plunge dipping for tick control.
Uganda 2025-02-14 15:53:01 2028-02-14 Natural Sciences Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Resilience Enhancement for Ticks and Tick-borne Diseases in Uganda [ResTick-U]
REFNo: NS1117ES

General Objective The general objective of this study will be to determine; the drivers of the sporadic occurrence and transmission dynamics of CCHFV, the effect of agro-ecological zones and seasonality on tick abundance | diversity and therefore their vectorial potential, the different tick species that are competent vectors of CCHFV, the molecular and metabolic mechanisms underlying acaricide resistance in different sub-Saharan ecologies , risk of CCHFV outbreaks in different acaricide resistance gradients and the role of acaricide resistance in acerbating tick-borne pathogens [TBPs] transmission , design and evaluate bed-side molecular diagnostics for CCHFV, socio-economic impact of acaricide resistance and the gender-segregated factors that facilitate its emergence and transmission, and build dynamic models that explain the sporadic nature of CCHFV and forecast future CCHFV outbreaks or identify very high-risk areas for targeted surveillance. Specific Objectives The specific objectives of this study will be to determine, i.The prevalence and seasonal variation in tick species from different AEZs of Uganda. ii.The prevalence and seasonal variation in CCHFV genotypes [and other tick-borne viruses (virome) in ticks across different AEZs of Uganda. iii.The prevalence and seasonal variation in CCHFV genotypes in cattle from different AEZs of Uganda. iv. The prevalence and seasonal variation in CCHFV genotypes in humans from different AEZs of Uganda. v.* Molecular mechanisms that underpin acaricide [Organophosphates, Formamidines, Pyrethroids, and Macrocyclic lactones] resistance levels [low, mid and high] in different AEZs of Uganda vi. *Biochemical mechanisms that underpin acaricide [Organophosphates, Formamidines, Pyrethroids, Macrocyclic lactones & Fipronil ] resistance levels [low, mid and high] in different AEZs of Uganda vii. The socio-economic impact of acaricide resistance in different AEZs of Uganda viii.The gender-segregated factors that drive acaricide resistance in different AEZs of Uganda ix.The diagnostic performance [compared to standard of care molecular diagnostics] of a new POC CCHFV diagnostic tool [Pebble, Technology] when used for detection of CCHFV genotypes in cattle, ticks, and humans x.The cost-effectiveness [compared to standard of care molecular diagnostics] of POC CCHFV diagnostic [Pebble, Technology] when used for detection of CCHFV genotypes in cattle, ticks, and humans xi. Fit mathematical [maximum entropy (MaxEnt) and ecological niche factor analysis (ENFA)] model(s) that best explain(s) /predict(s) tick population and CCHFV dynamics under different AEZs of Uganda *These research Objectives will be resolved at individual acaricide level to make them specific enough. We have kept them at group level for now because we are unable to know the different acaricides that are heavily used in different AEZs
Uganda 2026-01-30 16:51:36 2029-01-30 Natural Sciences Non-Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Evaluation of The Safety, Efficacy and Stability of Sangaphos Emulsifiable Concentrate [E.C]: A Randomised Single-Blinded Positive Controlled Multi-Site Acaricide Field Trial
REFNo: NS1171ES

General objectives: To determine the efficacy, safety, and stability of SangaPhos [Sanga Vet. Chem. Ltd, Kampala Industrial Park, Namanve] when applied onto cattle by hand spraying and plunge dipping for tick control. Specific objectives The specific objectives of this acaricide field trial will to determine; i.Efficacy of Sangaphos when applied onto cattle by hand spraying and plunge dipping for tick control. ii.Safety of Sangaphos when applied onto cattle by hand spraying and plunge dipping for tick control. iii.Stability of Sangaphos when applied onto cattle by plunge dipping for tick control.
Uganda 2026-03-03 12:23:56 2029-03-03 Natural Sciences Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Evaluation of The Safety, Efficacy and Stability of SangaDelta Emulsifiable Concentrate [E.C]: A Randomised Single-Blinded Positive Controlled Multi-Site Acaricide Field Trial
REFNo: NS1194ES

General objectives
To determine the efficacy, safety, and stability of SangaDelta (Sanga Vet. Chem. Ltd, Kampala Industrial Park, Namanve ) when applied onto cattle by hand spraying and plunge dipping for tick control.

Specific objectives
The specific objectives of this acaricide field trial will to determine:
i.Efficacy of SangaDelta when applied onto cattle by hand spraying and plunge dipping for tick control.
ii.Safety of SangaDelta when applied onto cattle by hand spraying and plunge dipping for tick control.
iii.Stability of SangaDelta when applied onto cattle by plunge dipping for tick control.

Uganda 2026-03-19 16:13:37 2029-03-19 Natural Sciences Clinical Trial Non-degree Award
SUSAN BALEKE ATUHAIRWE
ID: UNCST-2019-R001107
SAFETY, EFFECTIVENESS AND ACCEPTABILITY OF MISOPROSTOL FOR TREATMENT OF INCOMPLETE MID TRIMESTER ABORTION IN UGANDA
REFNo: HS153ES

1) To determine the burden of abortion morbidity among near-miss cases in Uganda. 2) To compare the safety and effectiveness of diagnosis and misoprostol administration by midwives versus physicians for management of incomplete mid trimester abortion. 3) Explore health workers’ experiences of and perceptions towards the use of misoprostol for management of incomplete mid trimester abortion. 4) To compare the acceptability of PAC using misoprostol by intervention type (midwives vs. physicians), in the mid trimester. 5) To determine the post abortion contraceptive uptake and continuation over 12 months for LARCs versus SARCs.
Uganda 2018-06-13 2021-06-13 Medical and Health Sciences Degree Award
Johnblack Kabukye Kabaalu
ID: UNCST-2019-R001109
Assessment of Organizational readiness to Implement Electronic Health Record Systems in Oncology in Low resource settings: A case study of the Uganda Cancer Institute
REFNo: IS14ES

1. To assess the level of organizational readiness of the Uganda Cancer Institute to implement an EHR as perceived by the staff 2. To determine which factors contribute to this readiness perception.
Uganda 2018-09-14 2021-09-14 Social Science and Humanities Degree Award
Johnblack Kabukye Kabaalu
ID: UNCST-2019-R001109
Requirements for an Interactive Voice Response system for provision of cancer information to patients and general public in Uganda
REFNo: HS418ES

To co-create a program theory for development, implementation and evaluation of IVR system for provision of cancer information to patients and general public in Uganda
Uganda 2019-07-10 2022-07-10 Medical and Health Sciences Degree Award
Johnblack Kabukye Kabaalu
ID: UNCST-2019-R001109
PEPROOM Patient Engagement and Patient-Reported Outcomes in Oncology using Mobile health tools in Uganda: A mixed-methods formative study
REFNo: SS3900ES

Main Objective
1. This project aims to enhance patient engagement and empowerment by increasing cancer awareness through efficient and effective dissemination of cancer information and advice. It also aims to develop/adapt patient-reported outcomes (PROs) measures for patients with cancer in Uganda, and improve PROs through cancer awareness, PRO tracking, reminders and personalized support. Overall, the project will contribute to research and evidence on patient-centered care in Uganda.
Specific Objectives
1. to explore knowledge, attitudes, and practices of cancer care providers and patients at the Uganda Cancer Institute (UCI) with regards to patient empowerment and patient-reported outcomes (PROs
2. to identify PROs considered most important, relevant, and/or actionable for cancer care at the UCI, and develop/adapt measures (tools) to track these PROs
3. to develop, implement, and evaluate a telephone system for automated provision of cancer information related to the PROs and for administration of the PRO measures in (ii) above (i.e., in audio telephone questionnaire format)
4. to study the impact of the telephone system on the PROs above and other selected clinical care processes and outcomes (e.g., satisfaction with care, adherence to appointments, disease progression)
Uganda 2025-05-23 13:23:23 2028-05-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Gavin Ackers Johnson
ID:
Assessing the Resistance Patterns of Bacteria Isolated from Cases of Maternal Sepsis at Fort Portal Regional Referral Hospital, Uganda; and Further Investigating the Potential Mechanisms of Antibiotic Resistance in the Staphylococcus aureus isolates obtai
REFNo: HS249ES

1. To determine the most common bacterial species that are associated with maternal sepsis at Fort Portal Regional Referral Hospital and their resistance profiles. 2. To use molecular typing to assess Staphylococcus aureus isolates and determine whether patients are being infected by the same strains, which may provide clues as to sources of infection 3. To identify the mechanisms of any antibiotic resistance observed.
UK 2019-02-26 2022-02-26 Medical and Health Sciences Degree Award
JIMMY SSEMALULU
ID:
PRESCRIPTION PRACTICES AND USE OF LABORATORY PARAMETERS TO MONITOR EFFICACY AND TOXICITY OF ANTIRETROVIRAL THERAPY (ART) AMONG HIV PATIENTS (15YEARS AND ABOVE) AT ART CLINIC IN BUTABIKA NATIONAL PSYCHIATRIC REFERRAL HOSPITAL, UGANDA.
REFNo: HS151ES

STUDY OBJECTIVES General objective To assess prescription practices and use of laboratory parameters to monitor efficacy and toxicity of ART among HIV patients (15 years and above) at ART clinic in Butabika hospital. 1.5.2 Specific objectives 1. To describe pharmaceuticals prescribed for HIV patients (15 years and above) at ART clinic in Butabika hospital. 2. To determine drug drug interactions between ARVs and other medicines prescribed to HIV patients (15 years and above) at ART clinic in Butabika hospital. 3. To identify laboratory parameters used to monitor treatment response and toxicity of ARVs among HIV patients (15 years and above) on ART in Butabika hospital.
Uganda 2018-04-11 2021-04-11 Medical and Health Sciences Degree Award
Laura Schmucker
ID:
Piloting exercise: Evaluation of the impact of the ‘Solar Suitcase’ installation in healthcare facilities in Uganda on quality of care during labor and delivery and reliability of electricity.
REFNo: HS150ES

By conducting the pilot, we seek to gain a greater understanding of the nature of electricity reliability and deliveries in rural health facilities. The main objectives of the pilot include: 1) Obtain data on volume of deliveries, electricity failures, and baseline measures of quality of maternity care in order to run accurate power calculations for the upcoming research study 2) Test survey tools in the local context and refine the questions to gather data required for the upcoming research study 3) Test and validate light sensor equipment 4) Observe quality of work of field staff of various backgrounds to determine which qualifications and prior experience are best placed to collect data for the upcoming research study
USA 2017-12-13 2020-12-13 Medical and Health Sciences Non-degree Award
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