Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Joseph Kirabira
ID: UNCST-2019-R001427
 MENTAL HEALTH CHALLENGES AND HEALTH-RELATED QUALITY OF LIFE ASSOCIATED WITH HIV STATUS DISCLOSURE AMONG YOUNG ADOLESCENTS IN EASTERN UGANDA
REFNo: HS3211ES

2. To determine the association between mental health challenges and health related quality of life after HIV disclosure among young adolescents,1. To determine the prevalence of mental health challenges (stigma, emotional and substance use disorders) associated with HIV status disclosure among young adolescents in Mbale, Eastern Uganda,To explore mental health challenges following HIV status disclosure and their association with health related quality of life among young adolescents aged 10-16 years.,
 Uganda 2023-12-01 15:46:03 2026-12-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Kirabira
ID: UNCST-2019-R001427
 Pediatric HIV Status Disclosure: Mental Health Outcomes, Barriers and Facilitators and Feasibility and Acceptability of Training Intervention in Improving Healthcare Workers’ Knowledge in Eastern Uganda.
REFNo: HS4017ES

1. To determine the prevalence of HIV status disclosure and association with mental health outcomes among CYALH in eastern Uganda. 2. To explore the experiences and coping mechanisms after HIV status disclosure after HIV status disclosure among young adolescents living with HIV in eastern Uganda 3. To explore the barriers and facilitators to HIV status disclosure to CYALH experienced by Healthcare workers (HCWs) in eastern Uganda . 4. To pilot and assess the feasibility and acceptability of a training intervention using WHO HIV status disclosure guidelines among HCWs to improve their knowledge about disclosure.
 Uganda 2024-07-02 12:35:50 2027-07-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Joseph Kirabira
ID: UNCST-2019-R001427
 ADAPTATION, FEASIBILITY AND ACCEPTABILITY OF CAREGIVER PEER-SUPPORTER FACILITATED HIV STATUS DISCLOSURE INTEVERNTION FOR CHILDREN IN EASTERN UGANDA – A TASK SHIFTING MODEL
REFNo: HS3547ES

To assess the feasibility and acceptability of the CPS facilitated disclosure intervention ,1. To culturally adapt a clinic-based pediatric HIV status disclosure intervention into CPS facilitated HIV status disclosure intervention among CLHIV and their caregivers in Uganda,To culturally adapt and assess the feasibility and acceptability of a CPS-facilitated HIV status disclosure intervention among caregivers of CLHIV at Jinja Regional Referral Hospital in Eastern Uganda. ,
 Uganda 2024-01-08 13:07:36 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Kirabira
ID: UNCST-2019-R001427
 A workshop-based learning for Medical Officers, Senior House Officers, Psychiatrists, and Pediatricians (Medical Doctors) in the use of medication in treating child and adolescent mental health conditions in Uganda.
REFNo: HS5877ES

Main Objective
1. To assess the current level of knowledge, skills, and practice of prescribing medications to address children and adolescents’ mental health conditions among medical doctors in Eastern Uganda.
2. To develop, evaluate and administer a workshop-based training materials on the use of medication in treating child and adolescent mental health conditions in Eastern Uganda.
Specific Objectives
1. To explore the knowledge, skills and practices of medical doctors regarding use of medications in treating child and adolescent mental health conditions in Eastern Uganda.
2. To develop and implement a workshop-based training for 50 medical doctors working with children and adolescents in Eastern Uganda.
3. To conduct an evaluation of the training programme among the medical doctors.
 Uganda 2025-06-05 8:49:35 2028-06-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 Pictures of ageing in Uganda: A pilot study to explore demography, healthy ageing phenotype and self-perception in a community of older people in Uganda
REFNo: SS246ES

Primary objective: To determine the feasibility of combining demographic, phenotypic and artistic methods in understanding the picture of Ageing of community dwelling elderly individuals in Uganda. Secondary objectives: 1) To assess the accuracy of age-reporting among older people (>60 years) living in a Wakiso District community and investigate how the accuracy of age-reporting is linked to health, capabilities, social status and residential circumstances. 2) To pilot test data collection tool for demographic assessment of older people in Uganda (culturally, linguistically, historically appropriate). 3) To pilot test data collection tools for phenotypic assessment of older people in Uganda (health status, frailty, cognition, capabilities, quality of life, co-morbidities including HIV, access to health and other services). 4) To assess feasibility and acceptability of undertaking cognitive testing using electronic tablets in older people living in a Wakiso District community. 5) To assess feasibility and acceptability of engaging older people through visual / performing arts activities. 6) To explore perceptions and attitudes to a community based participatory research in older people building on discussions/ interviews conducted in the context of 1-4 above. 7) To develop an exhibition of artwork by established artists and older people to express their perceptions of older age.
Uganda 2018-11-06 2021-11-06 Social Science and Humanities Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 ASSESSING THE IMPLEMENTATION OF THE POLICY AND REGULATIONS AGAINST SEXUAL HARASSMENT (PRASH) AT MAKERERE UNIVERSIT
REFNo: SS925ES

1. To assess the extent to which the recommendations from the 2018 committee on SM&H, and the 2018 amendments to PRASH have been implemented.
2. To conduct a dialogue among the University’s key stakeholders focused on addressing SM&H and creating a safe working and learning environment at the Makerere University.
3. To develop a set of recommendations to improve the monitoring and implementation of PRASH

 Uganda 2021-07-07 2024-07-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 A collaborative research program between Michigan State University and Makerere University psychiatry departments on climate change and gender-based violence in Uganda
REFNo: HS1517ES

To conduct key-informant interviews with key personnel in the identified organizations and other stakeholders.,To identify institutions and stakeholders in based in Kampala but who work in other Ugandan regions as well related to climate change mitigation and adaptation and GBV prevention.,To establish the initial activities and steps for the development of a joint MSU-MU research program in mental health factors associated with GBV and climate change. ,
 Uganda 2021-07-30 2024-07-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 The impact of the COVID-19 pandemic and its response on the mental health of people with pre-existing mental conditions in Uganda.
REFNo: HS1781ES

5. To explore the experiences and views of people with SMI, their families/caretakers and mental health clinicians regarding the MMHC,4. To assess the effectiveness of an outreach mobile mental health clinic (MMHC)7 initiative to mitigate the care and messaging gap for people with SMI during the Covid-19 pandemic and its response.,3. To explore the experiences and viewsof people with SMI and their families/caretakers regarding COVID -19 and its response ,2. To assess the effect of COVID -19 and its response on access to care for people with SMI ,1. To assess the effect of COVID -19 and its response on the mental health of people with SMI ,
 Uganda 2021-11-18 2024-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 Clonal Hematopoiesis: A Global Perspective on the Impact of CH on Alzheimer’s Disease in Sub-Saharan Africa
REFNo: HS5533ES

Main Objective
1. The aim of this proposed work is to compare the frequency and type of clonal hematopoiesis (CH) mutations in age-matched African American and Ugandan populations. We intend to determine the correlation between specific CH-associated mutations and development of Alzheimer’s Disease in both a Ugandan and African-American population.

Specific Objectives
1. Compare the frequency of CH in an elderly African American versus elderly Ugandan population.
2. Compare the types of CH mutations in an elderly African American versus elderly Ugandan population.
3. Determine the correlation between specific CH-associated mutations and the development of AD in a Ugandan population.
 Uganda 2025-03-19 12:53:37 2028-03-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 Vitamin D and Gut Microbiota and Dementia rick in older adults with chronic HIV infection and demographically matched community controls. Adverse Synergy of Gut Dysbiosis and Vitamin D Deficiency in Alzheimer’s Disease and Related Dementia among Community Controls and Older Adults with Chronic HIV-infection
REFNo: HS6600ES

2) To interrogate the potential for heightened ADRD risk in sub-groups that differ according to co-prevalent chronic HIV infection, NCD (specifically high blood pressure), as well as genetic risk such as APOE e4. ,1) To investigate how changes in the composition and metabolic capacity of the gut microbiota contribute to dysregulations in the metabolome of VD and impact ADRD, through an enhanced inflammatory response (systemic, intestinal and CNS). ,
 Uganda 2025-10-17 19:32:06 2028-10-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Padmasai Lakshmi Bhamidipati
ID:
Agency and Policy Change Shaping the Solar Energy Transitions in Uganda
REFNo: SS80ES

The overarching objective of this research is to capture the macro-dynamics and the socio-technical changes affecting the solar energy transitions, through an understanding of agency in institutions and policy changes. The aim is to study the electrification strategy at the national level, and with a specific focus at the rural electrification level - to examine the role, developments and debates in the solar energy sector (both grid and off-grid). Through this, the study will deconstruct the role of decentralized modern energy (such as off-grid solar) in alleviating energy access, the debates/contestations among the electricity institutions, the role of political forces in shaping the energy mix, and what does such a transition mean in a larger socio-economic and political context. This PhD project will help in a better understanding of the factors that support a transition to sustainable energy system and overall sustainable development in developing countries (which have a very low electrification rates at present). At the same time, the PhD project aims to provide a greater understanding of the role of transnational linkages and stakeholders within a national context, and the development of an innovation system in the solar sector in Uganda (in terms of changes in the local institutional and socio-economic structures, local competence-building and experience-based learning). The development of institutions and technical-economic capacities at a local level will create further market opportunities for private sector intervention in the solar sector.
India 2017-09-05 2020-09-05 Social Science and Humanities Degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis: a Phase III Randomized Controlled Trial. ANRS 12398 INTENSE-TBM
REFNo: HS804ES

The Primary objective is to assess the efficacy of two interventions to reduce mortality from TBM in adolescent and adults with or without HIV co-infection in sub-Saharan Africa:
• Intensified TBM treatment, compared to WHO standard TBM treatment
• Aspirin compared to not receiving Aspirin (placebo).

 Uganda 2020-12-10 2023-12-10 Medical and Health Sciences Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 A randomized clinical TriaL of early empiric Anti-Mycobacterium tuberculosis therapy for Sepsis in sub-Saharan Africa (ATLAS trial)
REFNo: HS1272ES

The primary hypothesis of this clinical trial protocol is that immediate and sepsis specific dose of anti-TB therapy will result in improved 28-day mortality for study participants admitted to hospital with HIV and sepsis in Tanzania and Uganda compared to standard care alone.

The primary objective is:
1) To conduct a randomized 2x2 factorial clinical trial of 1) immediate initiation of empiric anti-TB therapy plus standard care vs diagnosis dependent anti-TB therapy plus standard care alone and 2) sepsis-specific anti-TB therapy plus standard care vs conventional WHO weight-based anti-TB therapy plus standard care for patients presenting with sepsis to two hospitals in Uganda and Tanzania.
1a) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 28 day mortality compared to diagnosis dependent anti-TB therapy plus standard care.
1b) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 28 day mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.

The secondary objectives include:
1) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves in-hospital mortality compared to diagnosis dependent anti-TB therapy plus standard care
2) To determine if sepsis-specific dose anti-TB therapy plus standard care improves in hospital mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
3) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 6 month mortality compared to diagnosis dependent anti-TB therapy plus standard care
4) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 6 month mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
5) To determine the safety of increased dose anti-TB therapy for patients with sepsis
6) To determine if early achievement of target serum drug concentrations of isoniazid and rifampin, measured at day-2 of TB treatment, associates with more rapid clinical improvement among patients with confirmed TB.

 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 Determination of Adequate TUberculosis Regimen in Adults and adolescents hospitalised with HIV-associated severe immune suppression (Acronym: DATURA).
REFNo: HS1487ES

Primary objective: To estimate the impact of an intensified initial phase of tuberculosis (TB) treatment on mortality at 48 weeks among HIV-infected adults and adolescents hospitalised for TB with CD4 ≤ 100 cells/μL in comparison with the standard TB regimen. Secondary objectives: To estimate the impact of an intensified initial phase of TB treatment, in comparison with the standard TB regimen, on: ¥ Mortality at weeks 8 and 24 ¥ Adverse events, including: - All grade 3-4 events - Selected grade 2 events of interest - Drug-related adverse events - AIDS defining illnesses - Paradoxical TB-associated immune reconstitution inflammatory syndrome (IRIS) ¥ TB treatment success ¥ TB recurrence ¥ Antiretroviral treatment (ART) response in terms of virological success and immunological response ¥ Adherence to TB treatment and ART ¥ Peak plasma concentrations of rifampicin and isoniazid (and its N-acetyl-metabolite) at day 3, day 7 and week. ¥ Plasma concentrations of efavirenz and dolutegravir at week 4 (i.e. 2 weeks after the onset of ART)
Uganda 2021-07-16 2024-07-16 Medical and Health Sciences Clinical Trial Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 REDUCING MORTALITY IN ADULTS WITH ADVANCED HIV DISEASE (REVIVE)
REFNo: HS2892ES

To determine whether azithromycin is effective in reducing the incidence of new infection compared to placebo in adults with advanced HIV (CD4 ≤ 100 cells/mm3).,To determine whether azithromycin is effective in reducing mortality and hospitalisation at early and late timepoints (4weeks and 24weeks) compared to placebo in adults with advanced HIV (CD4 ≤ 100 cells/mm3).,To determine whether azithromycin is an effective and safe intervention to reduce excess mortality in adults with advanced HIV (CD4 ≤ 100 cells/mm3). ,
 Uganda 2023-09-27 17:43:49 2026-09-27 Medical and Health Sciences Clinical Trial Non-degree Award
Brenda Namugumya
ID:
Integrated nutrition strategies beyond paper realities: the case of Uganda
REFNo: SS83ES

The overall research question is “has Uganda’s adoption of integrated nutrition strategies (INS)resulted in actual changes in nutrition governance?” The specific research questions for the study are: 1) To what extent has nutrition been integrated into policy processes at various ministries? 2) What factors are facilitating or inhibiting integration of nutrition in policy processes of various ministries? 3)Have INS been consistently adopted into local government policy processes? 4)How has nutrition service delivery on the ground changed as a result of the adoption of the INS?
Uganda 2017-07-31 2020-07-31 Social Science and Humanities Degree Award
Vitaliano Cama
ID:
Evaluation of the Diagnostic Tests in Areas Hypoendemic for Onchocerciasis –Uganda
REFNo: HS90ES

) Evaluate the distribution of anti-OV-16 antibody and other markers of O. volvulus infection in multiple age groups. Data from this study may allow to determine the force of infection (rate at which susceptible individuals acquire an infection) using catalytic models
USA 2018-02-21 2021-02-21 Medical and Health Sciences Non-degree Award
Simon Wakwale Peter
ID:
POLITICAL DECENTRALISATION AND LOCAL GOVERNMENT PERFORMANCE: A CASE STUDY OF MBALE MUNICIPAL COUNCIL
REFNo: SS76ES

1. TO EXAMINE THE EFFECT OF DEVOLUTION OF POWERS ON TIMELY ACCOUNTABILITY IN MBALE MUNICIPAL COUNCIL 2. TO ASSESS THE EFFECT OF DEVOLUTION OF POWERS ON INFRASTRUCTURAL DEVELOPMENT IN MBALE MUNICIPAL COUNCIL 3. TO ESTABLISH THE EFFECT OF DEVOLUTION OF POWERS ON PROVISION OF SOCIAL SERVICES IN MBALE MUNICIPAL COUNCIL 4. TO FIND OUT THE EFFECT OF DEVOLUTION OF POWERS ON POLICY IMPLEMENTATION IN MBALE MUNICIPAL COUNCIL
Uganda 2018-04-24 2021-04-24 Social Science and Humanities Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Reducing exposure to household air pollution
REFNo: HS71ES

To evaluate the feasibility, acceptability and effectiveness of proven household air pollution reduction interventions in households using traditional way of cooking and heating methods in selected communities in four countries of Uganda, Vietnam, the Kyrgyz Republic and Greece. Research questions will be: 1. What is the feasibility and acceptability of clean cooking and heating interventions compared to traditional cooking and heating? 2. What is the effectiveness of a clean cooking intervention on health outcomes? 3. What is the effectiveness of household air pollution reduction on health outcomes?
 Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Global Excellence in Chronic Obstructive Pulmonary Disease Outcomes (GECO): Implementation of COPD case finding and self-management action plans in low and middle income countries.
REFNo: HS110ES

1. To determine whether case-finding for COPD can be facilitated using a modified 5-item questionnaire. 2. To determine whether a self-directed COPD Action Plan for the management of COPD exacerbations can be implemented with CHWs and local health care centers. 3. To determine whether a self-directed COPD Action Plan is cost-effective
Uganda 2017-10-31 2020-10-31 Medical and Health Sciences Non-degree Award
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