Winnie Muyindike R
ID: UNCST-2021-R013558
|
TB Risk by Alcohol Consumption
REFNo: HS1962ES
To determine the incidence of active TB disease among PLWH with prior LTBI, who received TPT, by level of alcohol use.
To estimate the incidence rate of new TB infection among PLWH with prior negative TST results by level of alcohol use.
To examine the risk of acquiring TB infection and of incident active TB disease among PLWH with heavy alcohol use after receipt of TPT in PLWH in Uganda.
|
Uganda |
2021-12-15 |
2024-12-15 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Winnie Muyindike R
ID: UNCST-2021-R013558
|
The Sentinel Research Network of IeDEA: A Prospective Cohort among People Living with HIV
REFNo: HS2217ES
Determine cross-sectional prevalence, incidence and progression over three years of liver enzyme (ALT/AST) elevation, non-invasive biomarkers of liver fibrosis (APRI, FiB-4, Fibroscan) and liver steatosis (CAP, Fatty Liver Index,Characterize the onset, chronicity and severity of mental health and substance use problems among older PLHIV over time as well as their interrelation and their influence on the HIV care continuum.,Determine the prevalence, incidence and predictors of cardio-metabolic disorders including diabetes mellitus, hypertension and dyslipidemia in PLHIV during a three-year follow-up period,To establish the IeDEA Sentinel Research Network (IeDEA-SRN)to prospectively capture and analyze standardized data among PLHIV in LMICs. Through this network, we further seek to implement studies focused on cardiovascular risk factors, mental health and substance use, as well as liver disease among PLHIV accessing HIV care in LMICs,
|
Uganda |
2022-09-06 15:07:47 |
2025-09-06 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Winnie Muyindike R
ID: UNCST-2021-R013558
|
HIV-1 subtype-specific drug resistance in patients failing dolutegravir-based first-line, second-line or third-line regimens: multiregional study (DTG resist study)”
REFNo: HS2435ES
Main Objective
1.To determine the patterns and spectrum of InSTI DRMs in adults and adolescents with virologic failure on DTG-based ART by ART regimen and HIV-1 subtype.
2. To identify risk factors for virologic failure, InSTI DRMs, and InSTI drug resistance in adolescents and adults on DTG-based ART, including drug, host and health system factors.
Specific Objectives
1a) To identify the prevalence of InSTI DRMs at the time of virologic failure.
1b) To compare the prevalence of InSTI DRMs at the time of virologic failure between HIV-1 subtypes and treatment contexts.
2a) To identify risk factors for Virologic Failure
2b) To identify risk factors for Drug Resistance Mutations.
3. To investigate correlations between novel resistance genotypes and phenotypic DTG resistance across HIV-1 subtypes.
|
Uganda |
2022-10-05 15:04:09 |
2025-10-05 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Winnie Muyindike R
ID: UNCST-2021-R013558
|
IeDEA East Africa Tuberculosis Sentinel Research Network (IeDEA-EA TB-SRN)
REFNo: HS2619ES
3. To describe post-TB lung disease (PTLD) and associations with HIV infection, diabetes, chronic lung disease, and tobacco and alcohol use, including measuring physiologic, structural, and functional impairment, health-related quality of life, and survival,2. To assess the individual-level effects of HIV and antiretroviral therapy (ART) on TB symptomatology, diagnosis, treatment response, and survival. ,1. To collect and analyze clinical and treatment data among people treated for pulmonary TB with or without HIV-co-infection, in order to improve understanding of the prognosis of TB disease and its health-related outcomes, including quality of life and survival.,The overarching objective/aim of the study is to assess pulmonary TB treatment and longer-term outcomes among people with and without HIV in TB-SRN sites in order to inform policy and practice around TB treatment and create a platform for additional TB research within IeDEA. ,
|
Uganda |
2023-01-11 12:47:27 |
2026-01-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Winnie Muyindike R
ID: UNCST-2021-R013558
|
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure for Individuals on TLD in Sub-Saharan Africa.(RESOLVE)
REFNo: HS2620ES
Aim 2: Use simulation modeling to examine the clinical impact, costs, and cost-effectiveness of strategies to improve viral suppression after virologic failure on TLD. We will populate the previously validated Cost-Effectiveness of Preventing AIDS Complications-International (CEPAC-I) model with the novel clinical trial data from Aim 1 to project long-term clinical outcomes and cumulative lifetime costs. We will then compare the cost-effectiveness of the three strategies evaluated in Aim 1 for addressing virologic failure among people treated with first-line TLD in Uganda or South Africa. ,Aim 1: Conduct a randomized clinical trial to determine the optimal strategy for management of virologic failure on first-line TLD in SSA. We will recruit 648 adolescents and adults with two viral loads >1,000 copies/mL while on first-line TLD for at least 12 months, who are in care at one of six public-sector HIV clinics in Uganda or South Africa. We will randomize participants to one of the following strategies, stratified by clinic and prior NNRTI-exposure: a) Maintenance on TLD with switch to protease inhibitor (PI)-based second-line ART if virologic failure persists past six months; b) Individualized Care, with regimen choice based on results of genotypic resistance tests and urine tenofovir assays; or c) Immediate Switch to PI-based second-line ART. The primary outcome will be viral suppression (<50 copies/mL) at 48 weeks post-enrollment using the FDA snapshot definition. We hypothesize that rates of viral suppression at 48 weeks will be higher in the Individualized Care arm than in the Maintenance on TLD and Immediate Switch arms.,
|
Uganda |
2023-02-09 11:06:56 |
2026-02-09 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Winnie Muyindike R
ID: UNCST-2021-R013558
|
Gabapentin to Reduce Alcohol and Improve Viral Load Suppression (GRAIL) – “Promoting Treatment as Prevention”
REFNo: HS2622ES
2. To assess the impact of gabapentin compared to placebo on: a) alcohol consumption; b) pain severity; c) ART adherence; and d) engagement in HIV care, in order to explore potential mechanisms by which gabapentin may lead to HVL suppression.,1. To test the efficacy of gabapentin versus placebo to achieve undetectable HVL (Primary Outcome at 3 months; Secondary Outcome at 6 & 12 months),
|
Uganda |
2023-01-18 18:33:54 |
2026-01-18 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Winnie Muyindike R
ID: UNCST-2021-R013558
|
The Phosphatidylethanol (PEth) Results Communication (PERC) Study
REFNo: HS4449ES
Main Objective: To develop and pilot strategies for using PEth results communication to boost alcohol brief interventions for PWH and explore their acceptability, appropriateness, and feasibility for a future large-scale Randomized Controlled Trial.
AIM 1: Develop approaches for adding PEth results communication to alcohol brief interventions.
AIM 2. Explore the acceptability, appropriateness, and feasibility of adding PEth results communication to an alcohol brief intervention in a pilot randomized controlled trial (RCT).
|
Uganda |
2024-09-12 11:23:21 |
2027-09-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
WILLIAM MUSAMBA
ID:
|
Sub-ethnic Identities and Political Conflict in Uganda: The Case of Busoga (1900 to 1967)
REFNo: SS485ES
1)To analyze the influence of British colonial rule on the ethno-political conflicts in Busoga, 2)To assess the position of the Kyabazingaship (Paramount Chieftaincy) in the ethno-political conflicts in Busoga, 3)To examine the nature of political activism of the civic movements in Busoga namely, Young Busoga Association, the Abataka Association and the Abataka Mwoyo Gwa Busoga (Landlords are the Heart of Busoga), 4)To explore the attitude of post-colonial national leadership towards the ethno-political conflicts in Busoga.
|
Uganda |
2020-07-28 |
2023-07-28 |
Social Science and Humanities |
|
Degree Award |
|
Wilson Mugizi
ID: UNCST-2022-R009877
|
Resource Based View Approach in Implementation of E-Learning in Selected Ugandan Public Universities
REFNo: SS1454ES
i. To examine the relationship between universities tangible resources and e-learning implementation during and beyond Covid-19 pandemic era in Uganda
ii. To evaluate the relationship between the universities intangible resources and e-learning implementation during and beyond Covid-19 pandemic era in Uganda.
iii. To assess the relationship between universities capabilities and e-learning implementation during and beyond Covid-19 pandemic era in Uganda.
iv. To suggest the strategies for management of e-waste resulting from implementation e-learning implementation.
|
Uganda |
2022-11-08 14:03:00 |
2025-11-08 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
MICHAEL JACKSON WAKWABUBI
ID:
|
Financial distress in local governments in Uganda
REFNo: SS1429ES
To establish the relationship between local government delivery system and financial distress in local governments in Uganda
To assess the relationship between revenue concentration and financial distress in local governments in Uganda
To examine the relationship between revenue concentration, local governance, corruption and LG delivery system in local governments in Uganda
To assess the mediating effect of LG delivery system in the relationship between revenue concentration, local governance, corruption and financial distress in local governments in Uganda
To establish the relationship between local governance and financial distress in local governments in Uganda
To establish the relationship between corruption and financial distress in local governments in Uganda
|
Uganda |
2022-11-03 11:38:10 |
2025-11-03 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
MISAKI WAYENGERA
ID:
|
Prevalence of Polymorphic genes of Alzheimer disease in Nodding disease Tauopathy.
REFNo: HS726ES
To determine if polymorphisms in the eight common genes associated with Alzheimer Disease (APP, MAPT, PREN-1, PREN-2, BACE-1, BACE-2, IDE, and APOE-ε4) are present in DNA of Nodding Disease patients
|
Uganda |
2021-05-18 |
2024-05-18 |
Medical and Health Sciences |
|
Degree Award |
|
MISAKI WAYENGERA
ID:
|
DEVELOPMENT OF AFFORDABLE, EASY TO USE, AND RAPID POINT OF CARE DIAGNOSTIC TESTING PLATFORMS FOR COVID-19 SUITING REMOTE SETTINGS OF SUB-SAHARAN AFRICA.
REFNo: HS1648ES
1.To optimize and validate reagents (recombinant peptides, monoclonal and polyclonal antibodies)’s performance towards capture of SARS- CoV 2 virus antigen and host specific antibodies
2.To develop prototypes of lateral flow immunochromatography test (LFT) and tube-agglutination test platforms for COVID19 testing
3.To perform In-dependent validation of the developed test platforms.
|
Uganda |
2021-12-03 |
2024-12-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Karugahe Wilber
ID:
|
Identifying psychosocial impact of COVID-19 and promising practices for meeting the mental health and protection needs to SGBV of vulnerable populations during a protracted crisis in Kampala Slums
REFNo: SS721ES
1. Identification of psychosocial and mental health issues/problems for potential SGBV victims as a result of COVID-19 pandemic.
2. To examine the relationship that exists between psychosocial and mental health issues, Sexual Gender based violence and Coping strategies among potential SGBV victims.
3. Identify the coping strategies to help potential SGBV victims to improve their mental health, avoid prevent its occurrence or re-occurrence.
|
Uganda |
2021-02-24 |
2024-02-24 |
Social Science and Humanities |
|
Non-degree Award |
|
EMMANUEL MPAMIZO
ID: UNCST-2023-R008388
|
MENTAL HEALTH SERVICES FOR CHILDREN AND ADOLESCENTS WITH HIV/AIDS IN GULU DISTRICT
REFNo: HS3035ES
1.To explore the barriers and facilitators of the provision of mental health services to CA-HIV in Gulu district.
2.To explore possible solutions to challenges in providing mental health services to CA-HIV in Gulu district.
|
Uganda |
2023-12-04 13:10:11 |
2026-12-04 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Tadeo Winyi
ID: UNCST-2024-R002357
|
FINANCIAL RESOURCE MANAGEMENT AND THE QUALITY OF EDUCATION IN HIGHER INSTITUTIONS: A CASE OF PRIVATE UNIVERSITIES IN CENTRAL UGANDA
REFNo: SS3719ES
The study's objectives are:
i. To assess the role of revenue streams in promoting quality of education in private universities in central Uganda.
ii. To determine the extent to which financial budgeting influences the quality of education in private universities in central Uganda.
iii. To analyze the effect of financial monitoring and control in the promotion of quality of education in private universities in central Uganda.
iv. To explore the mediating role of financial management practices between financial resource management and quality of education in private universities in central Uganda.
|
Uganda |
2025-04-11 14:31:27 |
2028-04-11 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Winny Akullo Nekesa
ID:
|
Adoption of Linked Data among University libraries in Uganda
REFNo: SS1338ES
The study will address the following specific objectives:
1. Determine the level of awareness of Linked Data among the professional librarians in Ugandan Universities.
2. Establish the extent of Linked Data adoption in Ugandan Universities.
3. Determine the potential benefits of adopting Linked Data in Ugandan Universities.
4. Investigate the factors that influence the professional librarians’ behaviour towards the adoption of Linked Data in Ugandan Universities.
5. Investigate the strategies to promote the adoption of Linked Data in Ugandan Universities.
|
Uganda |
2022-07-21 11:01:06 |
2025-07-21 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Winnifred Kansiime Kimara
ID: UNCST-2021-R012131
|
Predictors of indoor air quality in Kisenyi-Mugunu a slum settlement in Fort Portal Municipality, Uganda
REFNo: HS695ES
General objective
To assess predictors of indoor air quality so as to promote the health of children under five dwelling in Kisenyi-Mugunu, Fort Portal Municipality.
Specific objectives
1. To determine the level of IAQ in Kisenyi-Mugunu, Fort Portal Municipality.
2. To establish the predictors of IAQ in Kisenyi-Mugunu, Fort Portal Municipality.
3. To explore the barriers and facilitators to uptake of healthier household energy options in Kisenyi-Mugunu.
|
Uganda |
2020-11-18 |
2023-11-18 |
Medical and Health Sciences |
|
Non-degree Award |
|
Winnifred Kansiime Kimara
ID: UNCST-2021-R012131
|
VectorCAM Digital Innovations to Advance Entomology Surveillance
REFNo: HS2778ES
To evaluate the accuracy of the VectorCam tool, the results of the VectorCam in morphological mosquito identification through AI based technology in the field is compared to standard methods currently used in Uganda like morphological identification of mosquito under microscope and PCR testing for molecular identification for verification. Additionally, this study will evaluate the completeness, timeliness and cost-effectiveness of entomological surveillance data being captured through VectorCam by VHTs.
|
Uganda |
2023-12-21 20:57:33 |
2026-12-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Winnifred Kansiime Kimara
ID: UNCST-2021-R012131
|
Faecal exposure behaviours, risk profiles, and predicted efficacy of Water Sanitation and Hygiene interventions in Imvepi, Uganda and Cox’s Bazar, Bangladesh refugee settings
REFNo: HS5190ES
4. To predict the efficacy of suggested interventions on reducing faecal exposure in the private domain in Imvepi and Cox’s Bazar refugee settings (Study IV),3. To determine the factors associated with faecal exposure among children and adults in Imvepi and Cox’s Bazar refugee settings (Study III),2. To determine the faecal exposure risk profile of children and adults in the private and public domain of Imvepi and Cox’s Bazar refugee settings (Study II),1. To explore faecal exposure behaviours and pathways of children and adults in the private and public domain of Imvepi and Cox’s Bazar refugee settings (Study I),To establish the faecal exposure profiles and associated factors in the private and public domain and predict the efficacy of suggested interventions in Imvepi, Uganda and Cox’s Bazar, Bangladesh refugee settings so as to guide exposure reduction interventions.,
|
Uganda |
2024-12-23 12:01:21 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Winfred Nazziwa
ID: UNCST-2019-R000003
|
Alternative clinical Trial Designs and Methods :The Ethics of Controlled Human Infection studies in Low Resource Settings
REFNo: SS1925ES
The main objective of the study is to examine the ethics, perceptions and acceptability of controlled human infection studies in low resource settings. The specific objectives include;
1. To explore the perceptions of key research stakeholders on the conduct and oversight of controlled human infection studies.
2. To determine general public’s views about acceptability of controlled human infection studies.
3. To explore the experiences of research participants who have participated in a controlled human infection study in Uganda.
|
Uganda |
2023-08-25 8:44:58 |
2026-08-25 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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