Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Walter Ojok
ID: UNCST-2021-R004415
SYNTHESIS OF NOVEL MESOPOROUS ADSORBENTS FOR FLUORIDE REMOVAL FROM WATER
REFNo: NS158ES

(i) To study the hydrochemical characteristics of Ndali-Kasenda crater lakes used as water sources with focus on the occurrence and spatial distribution of fluoride.
(ii) To explore the possibility of synthesizing biosorbents for fluoride removal using local base materials (Phoenix reclinata seeds, cassava starch and banana extract as soft templates.
(iii) To conduct batch and column experiments on removal of fluoride using synthesized biosorbents to assess their fluoride removal performance.
(iv) To design laboratory scale pilot column filter studies for fluoride removal with high performance synthesized biosorbent for Ndali-Kasenda lake water.

Uganda 2021-09-03 2024-09-03 Natural Sciences Degree Award
Walter Komakech
ID: UNCST-2024-R015851
Community-Based Tourism for Local Economic Development: A Social Business Model Perspective in Northern Uganda
REFNo: SS4079ES

1.To explore the nature of the adoption of Community-based tourism for Local economic development in Northern Uganda

2.To examine the contributions of Community-based tourism to Local economic development.

3.To design a social business model to enhance Community-based tourism and local economic development in Northern Uganda

Uganda 2026-01-19 16:14:44 2029-01-19 Social Science and Humanities Non-Clinical Trial Degree Award
Vishakha Vasuki
ID:
Identification of zoonotic gastrointestinal parasites and environmental factors influencing the parasite status of mountain gorillas in Bwindi Impenetrable National Park, Uganda
REFNo: NS102ES

Aim 1: To determine the occurrence and pattern of distribution of parasitic pathogens in mountain gorillas in BINP by non-invasive collection of faecal samples from habituated and non-habituated mountain gorillas. Aim 2: Tracking daily travel patterns using Global Positioning System (GPS) and recording ecological data such as temperature, rainfall, humidity and altitude. Aim 3: Identification of Gastro-intestinal parasites in mountain gorillas using simple faecal floatation technique and agar plate coproculture.
India 2019-08-15 2022-08-15 Natural Sciences Degree Award
Vandana Sharma
ID:
Assessing StrongMinds’ Community-based Therapy Groups with a Gender Lens
REFNo: SS954ES

The overall objective of this research is to better understand gender outcomes of StrongMinds programming, including the experience of women participants of both in-person and remote IPT-G with respect to safety and GBV risks.
Canada 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Valerie Schoof Anna Mylene
ID:
PEOPLE & PRIMATES: A BIO-GEO-CULTURAL APPROACH TO UNDERSTANDING HUMAN-WILDLIFE INTERACTION
REFNo: NS120ES

We use a multidisciplinary bio-geo-cultural approach to examine the causes and consequences of perceived costs and benefits of human-wildlife interaction in different ecological and cultural settings to ultimately improve protection of biodiversity through mitigation of human-wildlife conflict (HWC) and sustained engagement with local communities at Lake Nabugabo, Uganda and Lewa-Borana Conservancy, Kenya. Specifically, our objectives are to: I) explore the role of landscape characteristics and ecological factors in understanding the behaviour and movement of vervet monkeys, II) evaluate community perceptions of wildlife and research in two villages in Uganda (Bbaale & Bukakata) and one in Kenya (Manyangalo), III) compare community perceptions of crop damage caused by wildlife to objective measurements of crop-foraging behaviour, and IV) develop community-relationships to facilitate long-term sociocultural and biological research on human-wildlife interaction and promote conservation via community outreach.
Canada 2022-07-08 9:08:38 2025-07-08 Natural Sciences Non-Clinical Trial Non-degree Award
Victoria Nambasa Prudence
ID: UNCST-2022-R008757
Landscape Assessment To Understand Maternal Vaccine Pharmacovigilance In Uganda
REFNo: HS2680ES

Main objective
The aim is to conduct a rapid assessment gap analysis and stakeholder mapping for safety monitoring of vaccines used in pregnancy and potential for use of Electronic Medical Record (EMR) for sentinel site surveillance in Uganda for post licensure studies as well as current tetanus and COVID-19 vaccination. The results of the assessment will inform areas of focus for establishment of robust safety surveillance of novel maternal vaccination and vaccines that maybe administered during pregnancy in pandemic situations in the country.
Specific objectives
1. Map stakeholders involved in regulation, policy setting, collection and reporting of adverse events following maternal vaccination and their linkages
2. Understand the existing methods, tools, and information flow for collecting and flow of adverse event following maternal vaccination
3. Mapping of current Electronic Health Record and registries roll-out and how they interface with national drug safety reporting system especially in relation to maternal vaccination
4. To understand the Community views, and perceptions on vaccination and reporting of AE during maternal immunization

Uganda 2023-03-02 15:08:39 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patrick  Vudriko
ID:
Survey to identify priority livestock diseases and diagnostic needs of animal health professionals and farmers in Central and Southwestern Uganda
REFNo: A84ES

Specific objectives
1. To identify the priority livestock and poultry diseases for which diagnostic services and diagnostic kits/aids are needed by various stakeholders (farmers, vets).
2. To assess the perception and attitudes of key stakeholders in the animal industry on the value and quality of existing animal diagnostic services in Uganda

Uganda 2021-08-27 2024-08-27 Agricultural Sciences Non-degree Award
Patrick  Vudriko
ID:
Innovations to Address Rampant Vaccine Failures, Shortages and Low Uptake for Sustainable Livestock Disease Control and Productivity in Uganda
REFNo: A136ES

The Proposal is designed to address selected immunizable diseases that affect health and productivity of poultry, small ruminant and cattle in Uganda. The study objectives include;
1. To assess the current animal vaccine supply chain and identify actors, distribution channels, use and constraints that affects animal vaccine utilization in Uganda.
2. To evaluate the level of protective Gumboro & IB virus disease antibodies among vaccinated chicken flocks in commercial farms.
3. To assess the sero-conversion of FMD vaccine and strengthen vaccination efficacy monitoring lab service at Research Center for Tropical Diseases and Vector Control (RTC) Laboratory at COVAB.
4. To assess the current PPR vaccination regimen and the clinical performance of combined PPR- SGP virus vaccine under field situations in small ruminants and develop a vaccination technical framework for effective control of the two diseases in Uganda.

Uganda 2021-08-25 2024-08-25 Agricultural Sciences Non-Clinical Trial Non-degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
Understanding the Marginalized Indigenous Batwa People of South-Western Uganda
REFNo: SS452ES

The general objective of the study is to generate data on the livelihood of Batwa indigenous community living in the districts of Kabale, Kisoro, Rubanda and Kanungu in Southwestern Uganda, in order to build evidence around the factors that compromise their livelihoods across policy, access to services and resources, culture and their history/heritage.

The specific objectives of the study will be:
1.To assess and understand the vulnerable issues and factors of marginalization of the Batwa from the districts of Kabale, Kisoro, Rubanda and Kanungu
2.To generate evidence on the social, structural and other barriers the Batwa Community face for their livelihood improvement interventions
3.To undertake participatory approaches to develop and evaluate development interventions improvement for the Batwa livelihoods
4.To propose recommendations on how to develop appropriate livelihood improvement programmes and policies for Batwa indigenous people communities living South Western Uganda.

Uganda 2020-10-27 2023-10-27 Social Science and Humanities Non-degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
Community-based Alternative Learning Environments for Parenting and Pregnant Teens: A Response to Uganda’s Increased Prevalence Due to the Impact of the COVID-19 Global Pandemic
REFNo: SS1487ES

This research aims to conduct a participatory assessment of factors that enhance adoption of alternative education environments for parenting and pregnant teens by involving communities in reflecting on and defining special needs for school re-entry and providing for second-chance education after pregnancy in Uganda.,To comprehensively disseminate the recommendations and guidelines for policy uptake,To co-create policy recommendations for community-based alternative education environments for parenting and pregnant teens,To conduct participatory multi-level needs assessment and policy pecommendations ,
Uganda 2022-11-23 12:28:32 2025-11-23 Social Science and Humanities Non-Clinical Trial Degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
Sexual and reproductive health and wellbeing during COVID-19: A study protocol for online national surveys and global comparative analyses
REFNo: SS560ES

The overall goal of this global study is to better understand sexual and reproductive health among adults during COVID-19 using an online convenience sample from 23 countries. The primary study aims are listed below:
1) To determine the impact of COVID-19 social restriction measures on sexual health, with a focus on safe sex practices
2) To determine the impact of COVID-19 social restriction measures on domestic violence, with a focus on gender-based violence
3) To determine the impact of COVID-19 social restriction measures on access to essential reproductive health commodities and services, including contraceptives, abortion, maternal health services

Secondary study aims including the following:
1) To determine the impact of COVID-19 social restriction measures on mental health
2) To determine the impact of COVID-19 social restriction measures on harmful cultural practices

3) To determine the impact of COVID-19 social restriction measures on STI and HIV/AIDS testing and treatment

4) To determine the impact of COVID-19 social restriction measures on nutrition


Uganda 2020-12-16 2023-12-16 Social Science and Humanities Non-degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
Promotion of a Safe Workplace Environment, Free from Gender-based Discrimination and Violence: A Policy Review and Action Research on the Prevalence of Workplace Gender Discrimination and Violence within the Agriculture, Tourism and Hospitality Sectors in the Rwenzori and Albertine Regions in Uganda
REFNo: SS2600ES

Develop action plans (1 per sector) based on research findings to address gender-based discrimination and violence, and create safe and inclusive work environments.,Identify support structures and mechanisms for work related Gender based discrimination and violence victims available in the region. ,Analyse existing policies and their gaps to address gender-based discrimination and violence at the workplace targeting selected sectors in Albertine and Rwenzori regions. ,To conduct action-oriented research on gender-based discrimination and gender-based violence (GBV) at the workplace targeting agriculture, tourism, and hospitality sectors in the Albertine and Rwenzori regions.,To contribute to the promotion of a Safe Workplace Environment, free from gender-based discrimination and gender-based violence.,
Uganda 2024-08-22 15:26:06 2027-08-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
Caregiver-Adolescent Sexuality Communication among Refugee and Host Communities in Southwestern and Northern Uganda (CONNECT)
REFNo: SS4216ES

3. Policy and community engagement objective: To establish and evaluate the contribution of multi-sectorial and development partners’ working committee in translation, sustainability, and scalability of the impacts of the caregiver-adolescent SRH communication intervention with resultant improvement in adolescent SRH policy and programming within refugee and host communities’ context in Southwestern and Northern Uganda. ,2. Gender Transformative Objective: To assess the social, economic, and cultural factors that influence the effective implementation of a gender-equitable caregiver-adolescent SRH communication and family functioning intervention within a multinational and multicultural refugee and host community context in Southwestern and Northern Uganda. ,1. Research objective: To contextualize, design, implement, and evaluate the effectiveness of caregiver-adolescent SRH communication intervention in refugee and host communities’ settings in Southwestern and Northern Uganda. ,The general objective of the project is to implement and evaluate a parent/caregiver-adolescent communication intervention on sexual and reproductive health (SRH), targeting social and cultural gender norms that hinder parental involvement in sexuality education among refugees and host communities in Nakivale and Bidi Bidi Refugee Settlements, Uganda. The project will assess the intervention\'s effectiveness in addressing the challenges faced by displaced and dysfunctional families in refugee and host community settings.,
Uganda 2025-09-12 16:55:54 2028-09-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Victoria Ndyanabangi
ID: UNCST-2021-R012645
Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum,DAIDS Study ID #38609, IND #146262
REFNo: HS1023ES

Primary Objectives
Component 1:
• To describe the PK parameters during pregnancy of selected ARV drugs administered to WLHIV who are not receiving TB drugs, and to compare these parameters to (a) historical PK data from non-pregnant women and (b) each participant’s own postpartum PK data.
Component 2:
• To describe the kinetics of (a) placental and breast milk transfer of CAB LA from mother to fetus/infant and (b) infant elimination of CAB LA acquired across the placenta after maternal dosing during pregnancy.
Component 3:
• To describe the PK parameters during pregnancy and postpartum of selected ARV drugs and first-line TB treatment drugs co-administered to WLHIV.
Component 4:
• To describe the PK parameters during pregnancy and postpartum of second-line TB treatment drugs administered to WLHIV and HIV-uninfected women.
Component 5:
• To describe the kinetics of drug transfer of selected ARVs from mother to infant via breast milk.
Secondary Objectives
All Components:
• To describe maternal and infant safety and clinical outcomes.
Components 1, 3 and 4:
• To compare drug concentrations in plasma from cord blood with concentrations in maternal plasma at delivery for selected ARV and/or TB treatment drugs.
• To describe the neonatal elimination of selected ARV and/or TB treatment drugs acquired across the placenta after maternal dosing during pregnancy.
Components 3 and 4:
• To describe the kinetics of drug transfer of selected ARVs and/or TB treatment drugs from mother to infant via breast milk
Component 4:
• To describe the PK parameters of selected ARVs when co-administered with selected second-line TB treatment drugs to WLHIV during pregnancy and postpartum.
Other Objectives
• To assess plasma protein binding of highly bound ARVs and/or TB treatment drugs during pregnancy and postpartum.
• To explore genetic sources for variability in drug exposure in pregnant and postpartum women and their infants for selected ARV and/or TB treatment drugs.

Uganda 2021-12-16 2024-12-16 Medical and Health Sciences Non-degree Award
Victoria Ndyanabangi
ID: UNCST-2021-R012645
IMPAACT 2036: Phase I/II Study of the Safety, Tolerability,Acceptability, and Pharmacokinetics of Oral and Long-ActingInjectable Cabotegravir and Rilpivirine in Virologically SuppressedChildren Living with HIV-1, Two to Less Than 12 Years of Age, DAIDSStudy ID #38932 IND # 138754
REFNo: HS2688ES

To propose the weight band dosing of oral cabotegravir (CAB) + oral rilpivirine (RPV)followed by long-acting injectable CAB (CAB LA) + long-acting injectable RPV (RPV LA)in children living with HIV-1, and to describe participant choice and experience with theregimen with or without an oral lead-in period.
To describe the repeat-dose pharmacokinetics of CAB + RPV (oral and injectable)through Week 24
To assess the safety of the oral lead-in of CAB + RPV, and the safety of CAB + RPV (oraland injectable) through Week 24
To assess the safety of CAB + RPV (oral and injectable) through Weeks 48 and 72
To describe the repeat-dose pharmacokinetics of injectable CAB LA + RPV LA throughWeeks 48 and 72
To assess the maintenance of viral suppression of CAB + RPV (oral and injectable)through Weeks 24, 48, and 72
To evaluate the tolerability and acceptability of injectable CAB LA + RPV LA throughWeeks 24, 48, and 72
To describe HIV-1 genotypes and phenotypes for children who experience virologicfailure during study treatment
To assess immunologic activity of CAB + RPV (oral and injectable) through Weeks 24,48, and 72
To describe tolerability and acceptability of 48 weeks of CAB + RPV (oral and injectable)and 44 weeks of CAB LA + RPV LA (injectable only)
To describe the safety and repeat-dose pharmacokinetics of 48 weeks of CAB + RPV(oral and injectable) or 44 weeks of CAB LA + RPV LA (injectable only)
To describe the maintenance of viral suppression and immunologic activity of 48 weeks ofCAB + RPV (oral and injectable) or 44 weeks of CAB LA + RPV LA (injectable only)
To describe HIV-1 genotypes and phenotypes for children who experience virologicfailure during 48 weeks of CAB + RPV (oral and injectable) or during 44 weeks of CABLA + RPV LA (injectable only)
To characterize long-term safety and washout PK through 48 weeks after permanentdiscontinuation of injectable CAB LA + RPV LAV LA
To characterize PK of CAB + RPV oral formulations when dispersed in liquid vs. directly ingested (Weight Bands 3, 4 and 5)
Uganda 2023-03-16 12:55:20 2026-03-16 Medical and Health Sciences Clinical Trial Non-degree Award
Victoria Ndyanabangi
ID: UNCST-2021-R012645
IMPAACT 2024- Protocol Titled: Dose Finding, Safety and Tolerability Study of Daily Rifapentine Combined with Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age with and without HIV. DAIDS Study ID #38747,IND #171439
REFNo: HS6638ES

To determine weight-band dosing of a once-daily, 28-day regimen of isoniazid (INH) and rifapentine (RPT) (1HP) for the prevention of tuberculosis (TB) in children living with and without HIV.

Primary Objectives
Cohort 1 and Cohort 2
To determine the weight-band dosing of RPT taken as part of the 1HP regimen by evaluating:
⎯ PK RPT exposures among children with and without HIV
⎯ Safety and tolerability of the 1HP regimen among children with HIV while receiving twice-daily
DTG and children without HIV through 28 days of dosing

Cohort 2
• To evaluate the effect of RPT taken as part of the 1HP regimen on the PK of DTG
Secondary Objectives
Cohort 1 and Cohort 2
To evaluate the effect of covariates including age, weight, sex, ethnicity, nutritional status, and HIV-1 status on the PK of RPT taken as part of the 1HP regimen
• To evaluate the safety of the 1HP regimen through 24 weeks of follow-up
• To evaluate the palatability and acceptability of the 1HP regimen
• To evaluate adherence to the 1HP regimen

Cohort 2
• To evaluate the safety and tolerability of twice-daily DTG through 42 days among children with HIV who are receiving 1HP
• To evaluate virologic control (less than 200 copies/mL) at Day 42 among children taking a DTG-Based ARV treatment regimen co-administered with 1HP

Uganda 2026-03-30 12:54:54 2029-03-30 Medical and Health Sciences Clinical Trial Non-degree Award
Victoria Namuggala Flavia
ID: UNCST-2019-R000991
The gendered price of precarity. Young women navigating workplace sexual harassment.
REFNo: SS608ES

Principal aim
The principal aim of the project is to contribute to an understanding of the processes of empowerment of young females in response to (vulnerability to) WSH, in order to inform policy directions and civil society efforts aimed at empowering young workers.

Specific objectives are:
1) To contribute to a better understanding of processes of gaining voice and empowerment in response to WSH in different precarious labour settings, by highlighting variation between the formal and informal sector.
2) To contribute to empirical knowledge about WSH in sectors for which limited research exists, and from a youth perspective.
3) To raise awareness among relevant policy actors about the specific conditions that create vulnerability to WSH for young women working in selected formal and informal sectors, and help them design strategies to address this within employment interventions.
4) To contribute to policy development for addressing sexual harassment in the informal sector, in support of implementing Article 8 of ILO Convention 190.
5) To contribute to the development of an ‘everyday language’ in local vernacular in Uganda and Bangladesh, which policy actors, civil society, and young women can comfortably use to articulate WSH.

Uganda 2021-04-27 2024-04-27 Social Science and Humanities Non-degree Award
Victoria Namuggala Flavia
ID: UNCST-2019-R000991
Young Women and Men’s Aspirations and Resilience: Prospects for Livelihoods, Employment and Accountability before, during and beyond COVID – 19
REFNo: SS1093ES

The overall objective of this project is to explore and interrogate the aspirations and resilience of young women and men in Africa; how these may or may not have shifted through the COVID-19 crisis and the implications presented for public policy in Africa with case studies in Ethiopia, Ghana, Kenya, Nigeria, Rwanda, Senegal and Uganda. Specific objectives are to:
1. Examine Ugandan young women and men’s aspirations for their futures.
2. Identify and analyse gender and social norms that guide the lives and aspirations of young men and women in Uganda.
3. Establish whether young women and men’s aspirations have changed with the advent of COVID-19.
4. Analyse what the young women and men are experiencing in their lives and livelihoods in a COVID-19 world.
5. Determine the extent to which the various provisions, regulations and policies in the study countries are aligned with young women and men’s aspirations and ideas about what they see themselves doing in the future.
6. Document lessons learned about the adaptability and resilience of young women and men’s aspirations.

Uganda 2021-11-30 2024-11-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Victoria Namuggala Flavia
ID: UNCST-2019-R000991
Identity and Belonging: Indigenous Perspectives to Teenage Parenthood in Uganda
REFNo: SS1920ES

Overall, the study intends to explore from an indigenous perspective the influence of teenage parenthood on identity formation and belonging among young people in central Uganda.
Specifically, the study will;
1. Explore the gendered experiences relating to identity and belonging encountered by teenage parents in Kampala.
2. Examine the forms of resistance and agency teenage parents adopt in claiming their individual and collective identity as members of indigenous groups.
3. Explore indigenous community perceptions relating to teenage parenting in Kampala.
4. Examine social norms and language relating to teenage parenthood in Kampala

Uganda 2023-09-05 14:08:13 2026-09-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
Vivian Najjuka NA
ID:
Health Information Seeking Behavior of People Living With Vitiligo in South Western Uganda
REFNo: SS3061ES

1. To establish the health information seeking practices for People Living with Vitiligo in South Western Uganda. 2. To determine the level of satisfaction with the health information sources by People Living with Vitiligo in South Western Uganda. 3. To identify the challenges encountered by People Living with Vitiligo in South Western Uganda, while seeking for health information on Vitiligo condition. 4. To explore interventions for enhancing health information access for coping with the Vitiligo condition in South Western Uganda.,The study seeks to explore the health information seeking behavior of People Living with Vitiligo in South Western Uganda and to propose interventions for enhancing HI access for coping with the Vitiligo condition.,
Uganda 2024-09-27 22:09:53 2027-09-27 Social Science and Humanities Non-Clinical Trial Degree Award
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